Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson’s disease

In Parkinson’s disease (PD) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (DA) and glutamate (Glu) levels change, resulting in dysfunction of basal ganglia motor regulation. The PD patient presents motor dysfunction such as resting tremor, bradyk...

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Vydáno v:	Experimental brain research Ročník 240; číslo 6; s. 1713 - 1725
Hlavní autoři:	Wang, Xiaodong, Wang, Yinhao, Chen, Jian, Li, Juan, Liu, Yang, Chen, Wei
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2022 Springer Springer Nature B.V
Témata:	6-Hydroxydopamine Aerobic exercise Aerobic exercises Aerobics Analysis Animals Basal ganglia Biomedical and Life Sciences Biomedicine Bradykinesia Care and treatment Caudate-putamen Cellular signal transduction Chronic illnesses Complications and side effects Disease Diseases Dopamine Dopamine D2 receptors Dopamine receptors Exercise Exercise therapy Extracellular signal-regulated kinase Gait Glutamate Immunofluorescence Intervention Kinases MAP kinase Motor ability Movement disorders Neostriatum Neurodegenerative diseases Neurology Neurons Neurosciences Open-field behavior Parkinson's disease Phosphorylation Physical fitness Physiological aspects Prince Edward Island Prodynorphin Proenkephalin Protein kinase Protein kinases Psychological aspects Research Article Resting Risk factors Signal transduction Signaling Spiny neurons Substantia nigra Tests Tremor Washington, D.C Prince Edward Island Washington, D.C China Motor function Striatal medium spiny neurons Parkinson’s disease Aerobic exercise Erk/MAPK signaling
ISSN:	0014-4819, 1432-1106, 1432-1106
On-line přístup:	Získat plný text
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