Aerobic exercise improves motor function and striatal MSNs-Erk/MAPK signaling in mice with 6-OHDA-induced Parkinson’s disease

In Parkinson’s disease (PD) state, with progressive loss of dopaminergic neurons in the substantia nigra, the striatal dopamine (DA) and glutamate (Glu) levels change, resulting in dysfunction of basal ganglia motor regulation. The PD patient presents motor dysfunction such as resting tremor, bradyk...

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Bibliographic Details
Published in:	Experimental brain research Vol. 240; no. 6; pp. 1713 - 1725
Main Authors:	Wang, Xiaodong, Wang, Yinhao, Chen, Jian, Li, Juan, Liu, Yang, Chen, Wei
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Springer Berlin Heidelberg 01.06.2022 Springer Springer Nature B.V
Subjects:	6-Hydroxydopamine Aerobic exercise Aerobic exercises Aerobics Analysis Animals Basal ganglia Biomedical and Life Sciences Biomedicine Bradykinesia Care and treatment Caudate-putamen Cellular signal transduction Chronic illnesses Complications and side effects Disease Diseases Dopamine Dopamine D2 receptors Dopamine receptors Exercise Exercise therapy Extracellular signal-regulated kinase Gait Glutamate Immunofluorescence Intervention Kinases MAP kinase Motor ability Movement disorders Neostriatum Neurodegenerative diseases Neurology Neurons Neurosciences Open-field behavior Parkinson's disease Phosphorylation Physical fitness Physiological aspects Prince Edward Island Prodynorphin Proenkephalin Protein kinase Protein kinases Psychological aspects Research Article Resting Risk factors Signal transduction Signaling Spiny neurons Substantia nigra Tests Tremor Washington, D.C Prince Edward Island Washington, D.C China Motor function Striatal medium spiny neurons Parkinson’s disease Aerobic exercise Erk/MAPK signaling
ISSN:	0014-4819, 1432-1106, 1432-1106
Online Access:	Get full text
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