Mutant p53 in cancer: from molecular mechanism to therapeutic modulation

TP53 , a crucial tumor suppressor gene, is the most commonly mutated gene in human cancers. Aside from losing its tumor suppressor function, mutant p53 (mutp53) often acquires inherent, novel oncogenic functions, which is termed “gain-of-function”. Emerging evidence suggests that mutp53 is highly as...

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Bibliographic Details
Published in:	Cell death & disease Vol. 13; no. 11; pp. 974 - 14
Main Authors:	Chen, Xiaohua, Zhang, Taotao, Su, Wei, Dou, Zhihui, Zhao, Dapeng, Jin, Xiaodong, Lei, Huiwen, Wang, Jing, Xie, Xiaodong, Cheng, Bo, Li, Qiang, Zhang, Hong, Di, Cuixia
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 18.11.2022 Springer Nature B.V Nature Publishing Group
Subjects:	631/67/395 692/699/67 Antibodies Biochemistry Biomedical and Life Sciences Cancer Carcinogenesis - genetics Cell Biology Cell Culture Chemotherapy Ferroptosis Genes, p53 Genomic instability Humans Immunology Life Sciences Malignancy Microenvironments Mutants Mutation - genetics Neoplasms - drug therapy Neoplasms - therapy p53 Protein Radiation therapy Review Review Article Tumor Microenvironment Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumors
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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