Recurrent deletions in clonal hematopoiesis are driven by microhomology-mediated end joining

The mutational mechanisms underlying recurrent deletions in clonal hematopoiesis are not entirely clear. In the current study we inspect the genomic regions around recurrent deletions in myeloid malignancies, and identify microhomology-based signatures in CALR , ASXL1 and SRSF2 loci. We demonstrate...

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