Regulated cell death pathways in doxorubicin-induced cardiotoxicity

Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the e...

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Bibliographic Details
Published in:Cell death & disease Vol. 12; no. 4; pp. 339 - 15
Main Authors: Christidi, Effimia, Brunham, Liam R.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.04.2021
Springer Nature B.V
Nature Publishing Group
Subjects:
631/80/304
692/699/75/74
Animals
Antibodies
Apoptosis
Apoptosis - drug effects
Autophagy
Autophagy - drug effects
Biochemistry
Biomedical and Life Sciences
Cardiomyocytes
Cardiotoxicity
Cardiotoxicity - metabolism
Cell Biology
Cell Culture
Cell death
Chemotherapy
Doxorubicin
Doxorubicin - pharmacology
Ferroptosis
Humans
Immunology
Life Sciences
Myocytes, Cardiac - drug effects
Myocytes, Cardiac - metabolism
Necroptosis
Necroptosis - drug effects
Phagocytosis
Pyroptosis
Review
Review Article
ISSN:2041-4889, 2041-4889
Online Access:Get full text
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Summary:Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.
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ISSN:2041-4889
2041-4889
DOI:10.1038/s41419-021-03614-x