Regulated cell death pathways in doxorubicin-induced cardiotoxicity

Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the e...

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Veröffentlicht in:	Cell death & disease Jg. 12; H. 4; S. 339 - 15
Hauptverfasser:	Christidi, Effimia, Brunham, Liam R.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 01.04.2021 Springer Nature B.V Nature Publishing Group
Schlagworte:	631/80/304 692/699/75/74 Animals Antibodies Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Cardiomyocytes Cardiotoxicity Cardiotoxicity - metabolism Cell Biology Cell Culture Cell death Chemotherapy Doxorubicin Doxorubicin - pharmacology Ferroptosis Humans Immunology Life Sciences Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Necroptosis Necroptosis - drug effects Phagocytosis Pyroptosis Review Review Article
ISSN:	2041-4889, 2041-4889
Online-Zugang:	Volltext
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Abstract	Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.
AbstractList	Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing. Abstract Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing. Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.
ArticleNumber	339
Author	Christidi, Effimia Brunham, Liam R.
Author_xml	– sequence: 1 givenname: Effimia surname: Christidi fullname: Christidi, Effimia organization: Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia – sequence: 2 givenname: Liam R. orcidid: 0000-0002-3686-3807 surname: Brunham fullname: Brunham, Liam R. email: liam.brunham@ubc.ca organization: Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Department of Medicine, University of British Columbia, Department of Medical Genetics, University of British Columbia
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/33795647$$D View this record in MEDLINE/PubMed
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Snippet	Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has... Abstract Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this...
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SubjectTerms	631/80/304 692/699/75/74 Animals Antibodies Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Cardiomyocytes Cardiotoxicity Cardiotoxicity - metabolism Cell Biology Cell Culture Cell death Chemotherapy Doxorubicin Doxorubicin - pharmacology Ferroptosis Humans Immunology Life Sciences Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Necroptosis Necroptosis - drug effects Phagocytosis Pyroptosis Review Review Article
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Title	Regulated cell death pathways in doxorubicin-induced cardiotoxicity
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Volume	12
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