Regulated cell death pathways in doxorubicin-induced cardiotoxicity
Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the e...
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| Published in: | Cell death & disease Vol. 12; no. 4; pp. 339 - 15 |
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| Main Authors: | , |
| Format: | Journal Article |
| Language: | English |
| Published: |
London
Nature Publishing Group UK
01.04.2021
Springer Nature B.V Nature Publishing Group |
| Subjects: | |
| ISSN: | 2041-4889, 2041-4889 |
| Online Access: | Get full text |
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| Abstract | Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing. |
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| AbstractList | Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing. Abstract Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing. Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing.Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has limited the use of this potent drug. The mechanisms by which doxorubicin kills cardiomyocytes has been elusive and despite extensive research the exact mechanisms remain unknown. This review focuses on recent advances in our understanding of doxorubicin induced regulated cardiomyocyte death pathways including autophagy, ferroptosis, necroptosis, pyroptosis and apoptosis. Understanding the mechanisms by which doxorubicin leads to cardiomyocyte death may help identify novel therapeutic agents and lead to more targeted approaches to cardiotoxicity testing. |
| ArticleNumber | 339 |
| Author | Christidi, Effimia Brunham, Liam R. |
| Author_xml | – sequence: 1 givenname: Effimia surname: Christidi fullname: Christidi, Effimia organization: Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia – sequence: 2 givenname: Liam R. orcidid: 0000-0002-3686-3807 surname: Brunham fullname: Brunham, Liam R. email: liam.brunham@ubc.ca organization: Centre for Heart Lung Innovation, Department of Medicine, University of British Columbia, Department of Medicine, University of British Columbia, Department of Medical Genetics, University of British Columbia |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33795647$$D View this record in MEDLINE/PubMed |
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| Snippet | Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this has... Abstract Doxorubicin is a chemotherapeutic drug used for the treatment of various malignancies; however, patients can experience cardiotoxic effects and this... |
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| SubjectTerms | 631/80/304 692/699/75/74 Animals Antibodies Apoptosis Apoptosis - drug effects Autophagy Autophagy - drug effects Biochemistry Biomedical and Life Sciences Cardiomyocytes Cardiotoxicity Cardiotoxicity - metabolism Cell Biology Cell Culture Cell death Chemotherapy Doxorubicin Doxorubicin - pharmacology Ferroptosis Humans Immunology Life Sciences Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Necroptosis Necroptosis - drug effects Phagocytosis Pyroptosis Review Review Article |
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| Title | Regulated cell death pathways in doxorubicin-induced cardiotoxicity |
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