A tumor-specific endogenous repetitive element is induced by herpesviruses

Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomega...

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Bibliographic Details
Published in:	Nature communications Vol. 10; no. 1; pp. 90 - 13
Main Authors:	Nogalski, Maciej T., Solovyov, Alexander, Kulkarni, Anupriya S., Desai, Niyati, Oberstein, Adam, Levine, Arnold J., Ting, David T., Shenk, Thomas, Greenbaum, Benjamin D.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.01.2019 Nature Publishing Group Nature Portfolio
Subjects:	13 13/51 38/32 38/91 45/91 631/326/596/1553 631/326/596/2555 631/326/596/2557 631/337/384 Cancer Cell Line Cell Movement Colitis Cytomegalovirus Fibroblasts - metabolism Fibroblasts - virology Gene expression Gene Expression Regulation Genomes Herpesviridae Human Genetics Humanities and Social Sciences Humans IE1 protein IE2 protein In Situ Hybridization Interspersed Repetitive Sequences - physiology multidisciplinary Pathogenesis Proteins Regulatory mechanisms (biology) Replication Ribonucleic acid RNA RNA - genetics RNA - metabolism Science Science (multidisciplinary) Transcription Tumor cell lines Up-Regulation
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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