A tumor-specific endogenous repetitive element is induced by herpesviruses

Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomega...

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Published in:Nature communications Vol. 10; no. 1; pp. 90 - 13
Main Authors: Nogalski, Maciej T., Solovyov, Alexander, Kulkarni, Anupriya S., Desai, Niyati, Oberstein, Adam, Levine, Arnold J., Ting, David T., Shenk, Thomas, Greenbaum, Benjamin D.
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 09.01.2019
Nature Publishing Group
Nature Portfolio
Subjects:
13
13/51
38/32
38/91
45/91
631/326/596/1553
631/326/596/2555
631/326/596/2557
631/337/384
Cancer
Cell Line
Cell Movement
Colitis
Cytomegalovirus
Fibroblasts - metabolism
Fibroblasts - virology
Gene expression
Gene Expression Regulation
Genomes
Herpesviridae
Human Genetics
Humanities and Social Sciences
Humans
IE1 protein
IE2 protein
In Situ Hybridization
Interspersed Repetitive Sequences - physiology
multidisciplinary
Pathogenesis
Proteins
Regulatory mechanisms (biology)
Replication
Ribonucleic acid
RNA
RNA - genetics
RNA - metabolism
Science
Science (multidisciplinary)
Transcription
Tumor cell lines
Up-Regulation
ISSN:2041-1723, 2041-1723
Online Access:Get full text
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Summary:Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases. The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-018-07944-x