A tumor-specific endogenous repetitive element is induced by herpesviruses

Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomega...

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Veröffentlicht in:Nature communications Jg. 10; H. 1; S. 90 - 13
Hauptverfasser: Nogalski, Maciej T., Solovyov, Alexander, Kulkarni, Anupriya S., Desai, Niyati, Oberstein, Adam, Levine, Arnold J., Ting, David T., Shenk, Thomas, Greenbaum, Benjamin D.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 09.01.2019
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Cancer
Cell Line
Cell Movement
Colitis
Cytomegalovirus
Fibroblasts - metabolism
Fibroblasts - virology
Gene expression
Gene Expression Regulation
Genomes
Herpesviridae
Human Genetics
Humanities and Social Sciences
Humans
IE1 protein
IE2 protein
In Situ Hybridization
Interspersed Repetitive Sequences - physiology
multidisciplinary
Pathogenesis
Proteins
Regulatory mechanisms (biology)
Replication
Ribonucleic acid
RNA
RNA - genetics
RNA - metabolism
Science
Science (multidisciplinary)
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Tumor cell lines
Up-Regulation
ISSN:2041-1723, 2041-1723
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Abstract Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases. The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.
AbstractList Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases.
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases. The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases.The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.
The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases.Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases.
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases. The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here, Nogalski et al. show that herpesvirus infection induces HSATII RNA expression, which in turn affects virus replication and cell motility.
ArticleNumber 90
Author Greenbaum, Benjamin D.
Oberstein, Adam
Levine, Arnold J.
Nogalski, Maciej T.
Solovyov, Alexander
Kulkarni, Anupriya S.
Desai, Niyati
Shenk, Thomas
Ting, David T.
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  surname: Nogalski
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  organization: Department of Molecular Biology, Princeton University
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  givenname: Alexander
  surname: Solovyov
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  organization: Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Department of Pathology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai
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  givenname: Anupriya S.
  surname: Kulkarni
  fullname: Kulkarni, Anupriya S.
  organization: Massachusetts General Hospital Cancer Center, Harvard Medical School
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  givenname: Niyati
  surname: Desai
  fullname: Desai, Niyati
  organization: Massachusetts General Hospital Cancer Center, Harvard Medical School
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  organization: Department of Molecular Biology, Princeton University
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  organization: The Simons Center for Systems Biology, School of Natural Sciences, Institute for Advanced Study
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  fullname: Ting, David T.
  organization: Massachusetts General Hospital Cancer Center, Harvard Medical School
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  surname: Shenk
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  email: shenk@princeton.edu
  organization: Department of Molecular Biology, Princeton University
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  givenname: Benjamin D.
  surname: Greenbaum
  fullname: Greenbaum, Benjamin D.
  email: benjamin.greenbaum@mssm.edu
  organization: Department of Medicine, Hematology and Medical Oncology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Department of Oncological Sciences, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Department of Pathology, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, Icahn Institute for Data Science and Genomic Technology, Icahn School of Medicine at Mount Sinai
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Snippet Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and...
The human genome includes a large amount of repetitive sequence, such as human satellite II (HSATII), but their function remains largely unknown. Here,...
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13/51
38/32
38/91
45/91
631/326/596/1553
631/326/596/2555
631/326/596/2557
631/337/384
Cancer
Cell Line
Cell Movement
Colitis
Cytomegalovirus
Fibroblasts - metabolism
Fibroblasts - virology
Gene expression
Gene Expression Regulation
Genomes
Herpesviridae
Human Genetics
Humanities and Social Sciences
Humans
IE1 protein
IE2 protein
In Situ Hybridization
Interspersed Repetitive Sequences - physiology
multidisciplinary
Pathogenesis
Proteins
Regulatory mechanisms (biology)
Replication
Ribonucleic acid
RNA
RNA - genetics
RNA - metabolism
Science
Science (multidisciplinary)
Transcription
Tumor cell lines
Up-Regulation
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Title A tumor-specific endogenous repetitive element is induced by herpesviruses
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