Number of initial symptoms is more related to long COVID-19 than acute severity of infection: a prospective cohort of hospitalized patients

•Long COVID-19 was experienced by almost two-thirds of hospitalized patients.•High number of initial symptoms increases the risk of long COVID-19 infection.•Objective measures of COVID-19 severity are unable to predict long COVID-19.•Having hypertension and being female are also associated with pers...

Full description

Saved in:
Bibliographic Details
Published in:International journal of infectious diseases Vol. 118; pp. 220 - 223
Main Authors: Chan Sui Ko, Adrien, Candellier, Alexandre, Mercier, Marie, Joseph, Cédric, Schmit, Jean-Luc, Lanoix, Jean-Philippe, Andrejak, Claire
Format: Journal Article
Language:English
Published: Canada Elsevier Ltd 01.05.2022
Elsevier
The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases
Subjects:
Bacteriology
COVID-19
COVID-19 - complications
Emerging diseases
Female
Hospitalization
Human health and pathology
Humans
Hypertension - epidemiology
Infectious diseases
Intensive Care Units
Life Sciences
Long COVID
Male
Microbiology and Parasitology
Middle Aged
Mycology
Persistent symptoms
Prospective Studies
Pulmonology and respiratory tract
Risk factor
Risk Factors
SARS-CoV-2
Severity
Short Communication
Virology
COVID-19
Persistent symptoms
Severity
Long COVID
Risk factor
ISSN:1201-9712, 1878-3511, 1878-3511
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Long COVID-19 was experienced by almost two-thirds of hospitalized patients.•High number of initial symptoms increases the risk of long COVID-19 infection.•Objective measures of COVID-19 severity are unable to predict long COVID-19.•Having hypertension and being female are also associated with persistent symptoms.•Patients with a high number of initial symptoms should be closely monitored. Post–COVID-19 symptoms experienced by many survivors have a further devastating effect. This study aimed to analyze the risk factors associated with long COVID-19 in a prospective cohort of hospitalized patients including those requiring intensive care unit (ICU) transfer, taking into account objective measures of COVID-19 severity. Hospitalized patients with confirmed COVID-19 were enrolled. A structured follow-up visit was performed 4 months after hospital admission. Multivariable adjusted regression models were used to analyse the association between parameters at the acute phase and persistent symptoms. A follow-up visit was performed in 316 patients including 115 (36.4%) discharged from the ICU. Mean age was 64.1 years, and 201 patients (58.3%) were men. Female sex (odds ratio [OR], 1.94; 95% confidence interval [CI], 1.17-3.22; P =.01), hypertension (OR, 2.01; 95% CI, 1.22-3.31; P <.01), and the number of initial symptoms (NIS) (OR, 1.35; 95% CI, 1.17-1.54; P <.001) were significantly associated with long COVID-19. Number of persistent symptoms was significantly associated with NIS (adjusted incidence rate ratio [aIRR], 1.16; 95% CI, 1.11-1.22; P <.001), female sex (aIRR, 1.56; 95% CI 1.29-1.87; P <.001), hypertension (aIRR, 1.23; 95% CI, 1.02-1.50; P =.03), and length of stay in hospital (aIRR, 1.01; 95% CI, 1.005-1.017; P <.001). Our study suggested that female sex, hypertension, and NIS had a significant impact on persistent symptoms in hospitalized patients in contrast to severity of acute COVID-19 infection.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
PMCID: PMC8896858
ISSN:1201-9712
1878-3511
1878-3511
DOI:10.1016/j.ijid.2022.03.006