Revealing the role of the human blood plasma proteome in obesity using genetic drivers

Blood circulating proteins are confounded readouts of the biological processes that occur in different tissues and organs. Many proteins have been linked to complex disorders and are also under substantial genetic control. Here, we investigate the associations between over 1000 blood circulating pro...

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Veröffentlicht in:	Nature communications Jg. 12; H. 1; S. 1279 - 13
Hauptverfasser:	Zaghlool, Shaza B., Sharma, Sapna, Molnar, Megan, Matías-García, Pamela R., Elhadad, Mohamed A., Waldenberger, Melanie, Peters, Annette, Rathmann, Wolfgang, Graumann, Johannes, Gieger, Christian, Grallert, Harald, Suhre, Karsten
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 24.02.2021 Nature Publishing Group Nature Portfolio
Schlagworte:	38/79 45/43 631/208/205 692/308/2056 692/53/2423 692/699/1702/393 Adipose tissue Adult Aged Animal models Biological activity Blood Blood circulation Blood plasma Body Mass Index Body size Female Gene expression Genetic control Genomes Humanities and Social Sciences Humans Inflammation Insulin-like growth factor-binding protein 1 Lipid metabolism Lipid Metabolism - genetics Lipid Metabolism - physiology Lipids Male Mendelian Randomization Analysis Middle Aged multidisciplinary Obesity Obesity - genetics Obesity - metabolism Organs Plasma proteins Polygenic inheritance Proteins Proteome - metabolism Proteomes Proteomics - methods Science Science (multidisciplinary) Therapeutic targets
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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