The ASCIZ-DYNLL1 axis promotes 53BP1-dependent non-homologous end joining and PARP inhibitor sensitivity

53BP1 controls a specialized non-homologous end joining (NHEJ) pathway that is essential for adaptive immunity, yet oncogenic in BRCA1 mutant cancers. Intra-chromosomal DNA double-strand break (DSB) joining events during immunoglobulin class switch recombination (CSR) require 53BP1. However, in BRCA...

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Vydané v:	Nature communications Ročník 9; číslo 1; s. 5406 - 12
Hlavní autori:	Becker, Jordan R., Cuella-Martin, Raquel, Barazas, Marco, Liu, Rui, Oliveira, Catarina, Oliver, Antony W., Bilham, Kirstin, Holt, Abbey B., Blackford, Andrew N., Heierhorst, Jörg, Jonkers, Jos, Rottenberg, Sven, Chapman, J. Ross
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 17.12.2018 Nature Publishing Group Nature Portfolio
Predmet:	13/1 13/106 13/109 13/31 14/19 14/35 38/23 42/41 631/337/1427/2122 631/337/1427/2190 631/337/1427/2191 82/80 82/83 Adaptive immunity Adenosine diphosphate Animals Antigens Binding BRCA1 protein BRCA1 Protein - genetics Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cell Line, Tumor Chromatin Class switching Clonal deletion CRISPR-Cas Systems Cytoplasmic Dyneins - metabolism Deoxyribonucleic acid Dimerization DNA DNA Breaks, Double-Stranded DNA damage DNA End-Joining Repair - genetics Double-strand break repair Female Gene deletion Genomes Genomic instability Genomic Instability - genetics HEK293 Cells Homologous recombination Homology Humanities and Social Sciences Humans Immunity Immunoglobulins Inhibitors Localization MCF-7 Cells Mice Mice, Inbred C57BL Mice, Knockout multidisciplinary Mutation Non-homologous end joining Oligomerization Pathology Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Proteins Radiation Recruitment Ribose Science Science (multidisciplinary) Stability Targeted cancer therapy Transcription Transcription Factors - metabolism Tumor Suppressor p53-Binding Protein 1 - genetics
ISSN:	2041-1723, 2041-1723
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