The genomic landscape of Mongolian hepatocellular carcinoma

Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehens...

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Published in:Nature communications Vol. 11; no. 1; pp. 4383 - 13
Main Authors: Candia, Julián, Bayarsaikhan, Enkhjargal, Tandon, Mayank, Budhu, Anuradha, Forgues, Marshonna, Tovuu, Lkhagva-Ochir, Tudev, Undarmaa, Lack, Justin, Chao, Ann, Chinburen, Jigjidsuren, Wang, Xin Wei
Format: Journal Article
Language:English
Published: London Nature Publishing Group UK 01.09.2020
Nature Publishing Group
Nature Portfolio
Subjects:
45/23
45/91
631/208/191/2018
631/67/1504/1610/4029
631/67/69
Aged
Biomarkers, Tumor - genetics
Cancer
Carcinogenesis - genetics
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - virology
DNA Mutational Analysis
Etiology
Exome Sequencing
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Hepatectomy
Hepatitis
Hepatitis D - epidemiology
Hepatitis D - genetics
Hepatitis D - surgery
Hepatitis D - virology
Hepatitis Delta Virus - isolation & purification
Hepatocellular carcinoma
Humanities and Social Sciences
Humans
Incidence
Liver - pathology
Liver - surgery
Liver - virology
Liver cancer
Liver Neoplasms - epidemiology
Liver Neoplasms - genetics
Liver Neoplasms - surgery
Liver Neoplasms - virology
Male
Middle Aged
Molecular modelling
Mongolia - epidemiology
multidisciplinary
Mutation
p53 Protein
Prognosis
Science
Science (multidisciplinary)
Mongolia
ISSN:2041-1723, 2041-1723
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Abstract Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis. Mongolia has the highest incidence of—and mortality from—hepatocellular carcinoma (HCC) in the world. Here, the authors examine the genomic and transcriptomic landscape of Mongolian HCC, uncover novel driver mutations, and suggest distinct disease etiologies.
AbstractList Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis.Mongolia has the highest incidence of—and mortality from—hepatocellular carcinoma (HCC) in the world. Here, the authors examine the genomic and transcriptomic landscape of Mongolian HCC, uncover novel driver mutations, and suggest distinct disease etiologies.
Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis.Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis.
Mongolia has the highest incidence of—and mortality from—hepatocellular carcinoma (HCC) in the world. Here, the authors examine the genomic and transcriptomic landscape of Mongolian HCC, uncover novel driver mutations, and suggest distinct disease etiologies.
Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis. Mongolia has the highest incidence of—and mortality from—hepatocellular carcinoma (HCC) in the world. Here, the authors examine the genomic and transcriptomic landscape of Mongolian HCC, uncover novel driver mutations, and suggest distinct disease etiologies.
Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis.
ArticleNumber 4383
Author Wang, Xin Wei
Tovuu, Lkhagva-Ochir
Tudev, Undarmaa
Forgues, Marshonna
Budhu, Anuradha
Bayarsaikhan, Enkhjargal
Tandon, Mayank
Chinburen, Jigjidsuren
Candia, Julián
Lack, Justin
Chao, Ann
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  organization: Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Liver Cancer Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32873799$$D View this record in MEDLINE/PubMed
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Snippet Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here,...
Mongolia has the highest incidence of—and mortality from—hepatocellular carcinoma (HCC) in the world. Here, the authors examine the genomic and transcriptomic...
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SubjectTerms 45/23
45/91
631/208/191/2018
631/67/1504/1610/4029
631/67/69
Aged
Biomarkers, Tumor - genetics
Cancer
Carcinogenesis - genetics
Carcinoma, Hepatocellular - epidemiology
Carcinoma, Hepatocellular - genetics
Carcinoma, Hepatocellular - surgery
Carcinoma, Hepatocellular - virology
DNA Mutational Analysis
Etiology
Exome Sequencing
Female
Gene expression
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Hepatectomy
Hepatitis
Hepatitis D - epidemiology
Hepatitis D - genetics
Hepatitis D - surgery
Hepatitis D - virology
Hepatitis Delta Virus - isolation & purification
Hepatocellular carcinoma
Humanities and Social Sciences
Humans
Incidence
Liver - pathology
Liver - surgery
Liver - virology
Liver cancer
Liver Neoplasms - epidemiology
Liver Neoplasms - genetics
Liver Neoplasms - surgery
Liver Neoplasms - virology
Male
Middle Aged
Molecular modelling
Mongolia - epidemiology
multidisciplinary
Mutation
p53 Protein
Prognosis
Science
Science (multidisciplinary)
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Title The genomic landscape of Mongolian hepatocellular carcinoma
URI https://link.springer.com/article/10.1038/s41467-020-18186-1
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