The genomic landscape of Mongolian hepatocellular carcinoma

Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehens...

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Vydané v:	Nature communications Ročník 11; číslo 1; s. 4383 - 13
Hlavní autori:	Candia, Julián, Bayarsaikhan, Enkhjargal, Tandon, Mayank, Budhu, Anuradha, Forgues, Marshonna, Tovuu, Lkhagva-Ochir, Tudev, Undarmaa, Lack, Justin, Chao, Ann, Chinburen, Jigjidsuren, Wang, Xin Wei
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	London Nature Publishing Group UK 01.09.2020 Nature Publishing Group Nature Portfolio
Predmet:	45/23 45/91 631/208/191/2018 631/67/1504/1610/4029 631/67/69 Aged Biomarkers, Tumor - genetics Cancer Carcinogenesis - genetics Carcinoma, Hepatocellular - epidemiology Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - surgery Carcinoma, Hepatocellular - virology DNA Mutational Analysis Etiology Exome Sequencing Female Gene expression Gene Expression Profiling Gene Expression Regulation, Neoplastic Hepatectomy Hepatitis Hepatitis D - epidemiology Hepatitis D - genetics Hepatitis D - surgery Hepatitis D - virology Hepatitis Delta Virus - isolation & purification Hepatocellular carcinoma Humanities and Social Sciences Humans Incidence Liver - pathology Liver - surgery Liver - virology Liver cancer Liver Neoplasms - epidemiology Liver Neoplasms - genetics Liver Neoplasms - surgery Liver Neoplasms - virology Male Middle Aged Molecular modelling Mongolia - epidemiology multidisciplinary Mutation p53 Protein Prognosis Science Science (multidisciplinary) Mongolia
ISSN:	2041-1723, 2041-1723
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Shrnutí:	Mongolia has the highest incidence of hepatocellular carcinoma (HCC) in the world, but its causative factors and underlying tumor biology remain unknown. Here, we describe molecular characteristics of HCC from 76 Mongolian patients by whole-exome and transcriptome sequencing. We present a comprehensive analysis of mutational signatures, driver genes, and molecular subtypes of Mongolian HCC compared to 373 HCC patients of different races and ethnicities and diverse etiologies. Mongolian HCC consists of prognostic molecular subtypes similar to those found in patients from other areas of Asia, Europe, and North America, as well as other unique subtypes, suggesting the presence of distinct etiologies linked to Mongolian patients. In addition to common driver mutations (TP53, CTNNB1) frequently found in pan-cancer analysis, Mongolian HCC exhibits unique drivers (most notably GTF2IRD2B, PNRC2, and SPTA1), the latter of which is associated with hepatitis D viral infection. These results suggest the existence of new molecular mechanisms at play in Mongolian hepatocarcinogenesis. Mongolia has the highest incidence of—and mortality from—hepatocellular carcinoma (HCC) in the world. Here, the authors examine the genomic and transcriptomic landscape of Mongolian HCC, uncover novel driver mutations, and suggest distinct disease etiologies.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-020-18186-1