Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism

Antibiotic-induced microbiome depletion (AIMD) has been used frequently to study the role of the gut microbiome in pathological conditions. However, unlike germ-free mice, the effects of AIMD on host metabolism remain incompletely understood. Here we show the effects of AIMD to elucidate its effects...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 2872 - 13
Main Authors:	Zarrinpar, Amir, Chaix, Amandine, Xu, Zhenjiang Z., Chang, Max W., Marotz, Clarisse A., Saghatelian, Alan, Knight, Rob, Panda, Satchidananda
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20.07.2018 Nature Publishing Group Nature Portfolio
Subjects:	101/58 38 38/22 38/23 38/39 38/77 38/88 38/90 38/91 45 59 631/326/2565/2134 631/443/319/1557 631/443/319/320 64/60 96/98 Adipose tissue Amphotericin B - administration & dosage Ampicillin - administration & dosage Animals Anti-Bacterial Agents - pharmacology Antibiotics Bile Bile Acids and Salts - chemistry Blood Glucose - metabolism Body Composition Body Weight Cecum Cecum - metabolism Colon - drug effects Colon - metabolism Colon - microbiology Depletion Energy utilization Fatty acids Fatty Acids, Volatile - chemistry Gastrointestinal Microbiome - drug effects Gene expression Gene Expression Regulation Germfree Glucagon Glucagon-like peptide 1 Glucose Glucose - metabolism Glucose tolerance Homeostasis Humanities and Social Sciences Insulin Insulin - metabolism Insulin Resistance Intestinal microflora Male Metabolism Metronidazole - administration & dosage Mice Mice, Inbred C57BL Microbiomes multidisciplinary Neomycin - administration & dosage Obesity - drug therapy Obesity - metabolism Obesity - microbiology RNA, Ribosomal, 16S - metabolism Science Science (multidisciplinary) Signaling Vancomycin - administration & dosage
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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