Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, information on mutation rates in normal tissues and und...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 2710 - 10
Main Authors:	Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 17.05.2022 Nature Publishing Group Nature Portfolio
Subjects:	45 45/23 631/337/1427/2121 631/67/1504/1885 631/67/68 631/67/69 692/4020/1503/1504/1885 Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Crypts DNA Mismatch Repair - genetics DNA repair Epithelial cells Epithelial Cells - pathology Epithelium Evolution Gene sequencing Genetic disorders Genomes Germ-Line Mutation Humanities and Social Sciences Humans Mismatch repair multidisciplinary Mutation Mutation rates Nucleotide sequence Organoids Pathogenesis Phylogeny Science Science (multidisciplinary) Tissues Tumors Whole genome sequencing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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