Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Lynch Syndrome (LS) is an autosomal dominant disease conferring a high risk of colorectal cancer due to germline heterozygous mutations in a DNA mismatch repair (MMR) gene. Although cancers in LS patients show elevated somatic mutation burdens, information on mutation rates in normal tissues and und...

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Vydáno v:	Nature communications Ročník 13; číslo 1; s. 2710 - 10
Hlavní autoři:	Lee, Bernard C. H., Robinson, Philip S., Coorens, Tim H. H., Yan, Helen H. N., Olafsson, Sigurgeir, Lee-Six, Henry, Sanders, Mathijs A., Siu, Hoi Cheong, Hewinson, James, Yue, Sarah S. K., Tsui, Wai Yin, Chan, Annie S. Y., Chan, Anthony K. W., Ho, Siu Lun, Campbell, Peter J., Martincorena, Inigo, Buczacki, Simon J. A., Yuen, Siu Tsan, Leung, Suet Yi, Stratton, Michael R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 17.05.2022 Nature Publishing Group Nature Portfolio
Témata:	45 45/23 631/337/1427/2121 631/67/1504/1885 631/67/68 631/67/69 692/4020/1503/1504/1885 Cancer Colorectal cancer Colorectal carcinoma Colorectal Neoplasms, Hereditary Nonpolyposis - genetics Crypts DNA Mismatch Repair - genetics DNA repair Epithelial cells Epithelial Cells - pathology Epithelium Evolution Gene sequencing Genetic disorders Genomes Germ-Line Mutation Humanities and Social Sciences Humans Mismatch repair multidisciplinary Mutation Mutation rates Nucleotide sequence Organoids Pathogenesis Phylogeny Science Science (multidisciplinary) Tissues Tumors Whole genome sequencing
ISSN:	2041-1723, 2041-1723
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