Substrate Rigidity Controls Activation and Durotaxis in Pancreatic Stellate Cells

Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive malignancy characterised by the presence of extensive desmoplasia, thought to be responsible for the poor response of patients to systemic therapies. Pancreatic stellate cells (PSCs) are key mediators in the production of this fibrotic stroma,...

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Bibliographic Details
Published in:	Scientific reports Vol. 7; no. 1; pp. 2506 - 12
Main Authors:	Lachowski, Dariusz, Cortes, Ernesto, Pink, Daniel, Chronopoulos, Antonios, Karim, Saadia A., P. Morton, Jennifer, del Río Hernández, Armando E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 31.05.2017 Nature Publishing Group Nature Portfolio
Subjects:	38 38/77 631/57/2268 631/67/327 Adenocarcinoma Adenocarcinoma - genetics Adenocarcinoma - pathology Carcinoma, Pancreatic Ductal - genetics Carcinoma, Pancreatic Ductal - pathology Cell Movement - genetics Cell Proliferation - drug effects Cell Proliferation - genetics Cellular Reprogramming - genetics Collagen - pharmacology Disease Progression Drug Combinations Extracellular matrix Fibrosis Gene Expression Regulation, Neoplastic - genetics Humanities and Social Sciences Humans Laminin - pharmacology Lipids Malignancy Medical research multidisciplinary Pancreas Pancreatic cancer Pancreatic Stellate Cells - drug effects Pancreatic Stellate Cells - pathology Primary Cell Culture Proteoglycans - pharmacology Rigidity Science Science (multidisciplinary) Stellate cells Stroma Substrate Specificity Tumor Microenvironment - genetics
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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