Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma

Osteolytic lesions (OL) characterize symptomatic multiple myeloma. The mechanisms of how malignant plasma cells (PC) cause OL in one region while others show no signs of bone destruction despite subtotal infiltration remain unknown. We report on a single-cell RNA sequencing (scRNA-seq) study of PC o...

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Bibliographic Details
Published in:	Nature communications Vol. 13; no. 1; pp. 807 - 15
Main Authors:	Merz, Maximilian, Merz, Almuth Maria Anni, Wang, Jie, Wei, Lei, Hu, Qiang, Hutson, Nicholas, Rondeau, Cherie, Celotto, Kimberly, Belal, Ahmed, Alberico, Ronald, Block, AnneMarie W., Mohammadpour, Hemn, Wallace, Paul K., Tario, Joseph, Luce, Jesse, Glenn, Sean T., Singh, Prashant, Herr, Megan M., Hahn, Theresa, Samur, Mehmet, Munshi, Nikhil, Liu, Song, McCarthy, Philip L., Hillengass, Jens
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 10.02.2022 Nature Publishing Group Nature Portfolio
Subjects:	38/91 45/23 631/67/2329 631/67/69 692/308/575 692/4028/67/1990/804 692/420/755 Biomedical materials Biopsy Bone diseases Bone Diseases - genetics Bone imaging Bone marrow Bone Marrow - metabolism Cluster Analysis Dkk1 protein Gene Expression Regulation, Neoplastic Gene sequencing Genes Genetic Heterogeneity Genomics Heterogeneity Humanities and Social Sciences Humans Induction therapy Lesions multidisciplinary Multiple myeloma Multiple Myeloma - genetics Multiple Myeloma - metabolism Multiple Myeloma - pathology Osteolysis Plasma Cells Ribonucleic acid RNA Science Science (multidisciplinary) Spatial heterogeneity Tissue inhibitor of metalloproteinase 1 Transcription Whole Exome Sequencing
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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