The genomic landscape of pediatric myelodysplastic syndromes

Myelodysplastic syndromes (MDS) are uncommon in children and have a poor prognosis. In contrast to adult MDS, little is known about the genomic landscape of pediatric MDS. Here, we describe the somatic and germline changes of pediatric MDS using whole exome sequencing, targeted amplicon sequencing,...

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Veröffentlicht in:	Nature communications Jg. 8; H. 1; S. 1557 - 10
Hauptverfasser:	Schwartz, Jason R., Ma, Jing, Lamprecht, Tamara, Walsh, Michael, Wang, Shuoguo, Bryant, Victoria, Song, Guangchun, Wu, Gang, Easton, John, Kesserwan, Chimene, Nichols, Kim E., Mullighan, Charles G., Ribeiro, Raul C., Klco, Jeffery M.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 16.11.2017 Nature Publishing Group Nature Portfolio
Schlagworte:	631/67/1990/1673 631/67/69 Adult Animals Cell Line Child Children Cohort Studies Copy number Disorders Gene sequencing Genetic Predisposition to Disease - genetics Genomics - methods HEK293 Cells Heterozygosity Humanities and Social Sciences Humans Loss of Heterozygosity MAP kinase Mice Monosomy multidisciplinary Mutation Myelodysplastic syndrome Myelodysplastic syndromes Myelodysplastic Syndromes - genetics Myelodysplastic Syndromes - pathology Patients Pediatrics Proteins - genetics Ribonucleic acid RNA Science Science (multidisciplinary) Splicing Survival Analysis Tumor cells Tumor Suppressor Proteins - genetics
ISSN:	2041-1723, 2041-1723
Online-Zugang:	Volltext
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