SPRTN protease-cleaved MRE11 decreases DNA repair and radiosensitises cancer cells

The human MRE11/RAD50/NBS1 (MRN) complex plays a crucial role in sensing and repairing DNA DSB. MRE11 possesses dual 3′−5′ exonuclease and endonuclease activity and forms the core of the multifunctional MRN complex. We previously identified a C-terminally truncated form of MRE11 (TR-MRE11) associate...

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Bibliographic Details
Published in:	Cell death & disease Vol. 12; no. 2; pp. 165 - 17
Main Authors:	Na, Juri, Newman, Joseph A., Then, Chee Kin, Syed, Junetha, Vendrell, Iolanda, Torrecilla, Ignacio, Ellermann, Sophie, Ramadan, Kristijan, Fischer, Roman, Kiltie, Anne E.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.02.2021 Springer Nature B.V Nature Publishing Group
Subjects:	13/106 13/2 13/31 13/44 13/89 14/34 631/337/1427 692/699/2768 82/58 82/80 Acid Anhydride Hydrolases - genetics Acid Anhydride Hydrolases - metabolism Antibodies Biochemistry Biomedical and Life Sciences Bladder cancer Cell Biology Cell Culture Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Line, Tumor Cell Proliferation - radiation effects Deoxyribonucleic acid DNA DNA Damage DNA Repair DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Double-strand break repair Endonuclease Exonuclease G2 Phase Cell Cycle Checkpoints - radiation effects HEK293 Cells Humans Immunohistochemistry Immunology Life Sciences Mass spectroscopy MRE11 Homologue Protein - genetics MRE11 Homologue Protein - metabolism MRE11 protein Nuclear Proteins - genetics Nuclear Proteins - metabolism Nuclease Post-translation Proteinase Proteolysis Radiation therapy Radiation Tolerance Radiosensitivity Site-directed mutagenesis Substrate Specificity Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - pathology Urinary Bladder Neoplasms - radiotherapy
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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