Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection
The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient an...
Gespeichert in:
| Veröffentlicht in: | Nature communications Jg. 11; H. 1; S. 6319 - 15 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
London
Nature Publishing Group UK
09.12.2020
Nature Publishing Group Nature Portfolio |
| Schlagworte: | |
| ISSN: | 2041-1723, 2041-1723 |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection. There is a spectrum of high and low virus cases associated with duration of disease. High viral cases have high activation of interferon pathway genes and a predominant M1-like macrophage infiltrate. Low viral cases are more heterogeneous likely reflecting inherent patient differences in the evolution of host response, but there is consistent indication of pulmonary epithelial cell recovery based on napsin A immunohistochemistry and RNA expression of surfactant and mucin genes. Using a digital spatial profiling platform, we find the virus corresponds to distinct spatial expression of interferon response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.
Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage. |
|---|---|
| AbstractList | The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection. There is a spectrum of high and low virus cases associated with duration of disease. High viral cases have high activation of interferon pathway genes and a predominant M1-like macrophage infiltrate. Low viral cases are more heterogeneous likely reflecting inherent patient differences in the evolution of host response, but there is consistent indication of pulmonary epithelial cell recovery based on napsin A immunohistochemistry and RNA expression of surfactant and mucin genes. Using a digital spatial profiling platform, we find the virus corresponds to distinct spatial expression of interferon response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage. The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection. There is a spectrum of high and low virus cases associated with duration of disease. High viral cases have high activation of interferon pathway genes and a predominant M1-like macrophage infiltrate. Low viral cases are more heterogeneous likely reflecting inherent patient differences in the evolution of host response, but there is consistent indication of pulmonary epithelial cell recovery based on napsin A immunohistochemistry and RNA expression of surfactant and mucin genes. Using a digital spatial profiling platform, we find the virus corresponds to distinct spatial expression of interferon response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection. The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection. There is a spectrum of high and low virus cases associated with duration of disease. High viral cases have high activation of interferon pathway genes and a predominant M1-like macrophage infiltrate. Low viral cases are more heterogeneous likely reflecting inherent patient differences in the evolution of host response, but there is consistent indication of pulmonary epithelial cell recovery based on napsin A immunohistochemistry and RNA expression of surfactant and mucin genes. Using a digital spatial profiling platform, we find the virus corresponds to distinct spatial expression of interferon response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection.The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection. There is a spectrum of high and low virus cases associated with duration of disease. High viral cases have high activation of interferon pathway genes and a predominant M1-like macrophage infiltrate. Low viral cases are more heterogeneous likely reflecting inherent patient differences in the evolution of host response, but there is consistent indication of pulmonary epithelial cell recovery based on napsin A immunohistochemistry and RNA expression of surfactant and mucin genes. Using a digital spatial profiling platform, we find the virus corresponds to distinct spatial expression of interferon response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection. Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage. The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients who succumbed to SARS-CoV-2 infection using a combination of different RNA and protein analytical platforms to characterize inter-patient and intra-patient heterogeneity of pulmonary virus infection. There is a spectrum of high and low virus cases associated with duration of disease. High viral cases have high activation of interferon pathway genes and a predominant M1-like macrophage infiltrate. Low viral cases are more heterogeneous likely reflecting inherent patient differences in the evolution of host response, but there is consistent indication of pulmonary epithelial cell recovery based on napsin A immunohistochemistry and RNA expression of surfactant and mucin genes. Using a digital spatial profiling platform, we find the virus corresponds to distinct spatial expression of interferon response genes demonstrating the intra-pulmonary heterogeneity of SARS-CoV-2 infection. Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be fatal. Here the authors analyze cadaveric pulmonary tissue and show one group with high viral load, early death, inflammation and inflammatory damage, and another with low viral load, longer duration of disease, and more M2-like polarization and fibrotic lung damage. |
| ArticleNumber | 6319 |
| Author | Warren, Sarah E. Neyaz, Azfar Rivera, Miguel N. Rueckert, Erroll H. Szabolcs, Annamaria Shih, Angela R. Mehta, Arnav Jaicks, Christopher Reeves, Jason W. Colvin, Robert B. Monroe, Robert Ting, David T. Greenbaum, Benjamin D. Raabe, Michael J. Juric, Dejan Nieman, Linda T. Stone, James R. Chen, Jonathan H. Solovyov, Alexander Lieb, David J. Pinto, Christopher J. Thapar, Vishal Kim, Arthur Y. Lagana, Stephen M. Sholl, Lynette M. Deshpande, Vikram Chebib, Ivan Hacohen, Nir Kulkarni, Anupriya S. Danaher, Patrick Gong, Jingjing Xu, Katherine H. Desai, Niyati |
| Author_xml | – sequence: 1 givenname: Niyati surname: Desai fullname: Desai, Niyati organization: Massachusetts General Hospital Cancer Center – sequence: 2 givenname: Azfar surname: Neyaz fullname: Neyaz, Azfar organization: Massachusetts General Hospital Cancer Center – sequence: 3 givenname: Annamaria orcidid: 0000-0003-4951-9914 surname: Szabolcs fullname: Szabolcs, Annamaria organization: Massachusetts General Hospital Cancer Center – sequence: 4 givenname: Angela R. surname: Shih fullname: Shih, Angela R. organization: Department of Pathology, Massachusetts General Hospital – sequence: 5 givenname: Jonathan H. surname: Chen fullname: Chen, Jonathan H. organization: Massachusetts General Hospital Cancer Center, Department of Pathology, Massachusetts General Hospital – sequence: 6 givenname: Vishal surname: Thapar fullname: Thapar, Vishal organization: Massachusetts General Hospital Cancer Center – sequence: 7 givenname: Linda T. surname: Nieman fullname: Nieman, Linda T. organization: Massachusetts General Hospital Cancer Center – sequence: 8 givenname: Alexander surname: Solovyov fullname: Solovyov, Alexander organization: Memorial Sloan Kettering Cancer Center – sequence: 9 givenname: Arnav surname: Mehta fullname: Mehta, Arnav organization: Massachusetts General Hospital Cancer Center, The Broad Institute – sequence: 10 givenname: David J. surname: Lieb fullname: Lieb, David J. organization: The Broad Institute – sequence: 11 givenname: Anupriya S. surname: Kulkarni fullname: Kulkarni, Anupriya S. organization: Massachusetts General Hospital Cancer Center – sequence: 12 givenname: Christopher surname: Jaicks fullname: Jaicks, Christopher organization: Massachusetts General Hospital Cancer Center – sequence: 13 givenname: Katherine H. surname: Xu fullname: Xu, Katherine H. organization: Massachusetts General Hospital Cancer Center – sequence: 14 givenname: Michael J. surname: Raabe fullname: Raabe, Michael J. organization: Massachusetts General Hospital Cancer Center – sequence: 15 givenname: Christopher J. surname: Pinto fullname: Pinto, Christopher J. organization: Massachusetts General Hospital Cancer Center – sequence: 16 givenname: Dejan orcidid: 0000-0003-2983-7704 surname: Juric fullname: Juric, Dejan organization: Massachusetts General Hospital Cancer Center – sequence: 17 givenname: Ivan surname: Chebib fullname: Chebib, Ivan organization: Department of Pathology, Massachusetts General Hospital – sequence: 18 givenname: Robert B. orcidid: 0000-0002-4493-4150 surname: Colvin fullname: Colvin, Robert B. organization: Department of Pathology, Massachusetts General Hospital – sequence: 19 givenname: Arthur Y. surname: Kim fullname: Kim, Arthur Y. organization: Department of Medicine, Massachusetts General Hospital – sequence: 20 givenname: Robert surname: Monroe fullname: Monroe, Robert organization: Advanced Cell Diagnostics, a Bio-Techne Brand – sequence: 21 givenname: Sarah E. surname: Warren fullname: Warren, Sarah E. organization: NanoString Inc – sequence: 22 givenname: Patrick orcidid: 0000-0002-2844-5883 surname: Danaher fullname: Danaher, Patrick organization: NanoString Inc – sequence: 23 givenname: Jason W. surname: Reeves fullname: Reeves, Jason W. organization: NanoString Inc – sequence: 24 givenname: Jingjing surname: Gong fullname: Gong, Jingjing organization: NanoString Inc – sequence: 25 givenname: Erroll H. surname: Rueckert fullname: Rueckert, Erroll H. organization: NanoString Inc – sequence: 26 givenname: Benjamin D. surname: Greenbaum fullname: Greenbaum, Benjamin D. organization: Memorial Sloan Kettering Cancer Center – sequence: 27 givenname: Nir orcidid: 0000-0002-2349-2656 surname: Hacohen fullname: Hacohen, Nir organization: Massachusetts General Hospital Cancer Center, The Broad Institute, Department of Medicine, Massachusetts General Hospital – sequence: 28 givenname: Stephen M. surname: Lagana fullname: Lagana, Stephen M. organization: Department of Pathology and Cell Biology, Columbia University Irving Medical Center – sequence: 29 givenname: Miguel N. surname: Rivera fullname: Rivera, Miguel N. organization: Massachusetts General Hospital Cancer Center, Department of Pathology, Massachusetts General Hospital, The Broad Institute – sequence: 30 givenname: Lynette M. orcidid: 0000-0002-9532-9735 surname: Sholl fullname: Sholl, Lynette M. organization: Department of Pathology, Brigham and Woman’s Hospital – sequence: 31 givenname: James R. orcidid: 0000-0001-9122-3311 surname: Stone fullname: Stone, James R. email: jrstone@mgh.harvard.edu organization: Department of Pathology, Massachusetts General Hospital – sequence: 32 givenname: David T. orcidid: 0000-0002-3261-2322 surname: Ting fullname: Ting, David T. email: dting1@mgh.harvard.edu organization: Massachusetts General Hospital Cancer Center, Department of Medicine, Massachusetts General Hospital – sequence: 33 givenname: Vikram orcidid: 0000-0003-4230-9308 surname: Deshpande fullname: Deshpande, Vikram email: vdeshpande@mgh.harvard.edu organization: Massachusetts General Hospital Cancer Center, Department of Pathology, Massachusetts General Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33298930$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9Uk1v1DAUjFARLaV_gAOKxIVLwF_xxwWpWgGtVAmJLlwtx3nZ9Sqxg-1U6r_H7bal7aG--MmeGY_fm7fVgQ8equo9Rp8xovJLYphx0SCCGoIwVY14VR0RxHCDBaEHj-rD6iSlHSqLKiwZe1MdUkqUVBQdVb_XMM0hmrE2vq_TbLIr9RYyxLABDy5f12GotyHlOkKag09Q51Bfnv66bFbhT0PqeRmn4E28rp0fwGYX_Lvq9WDGBCd3-3G1_v5tvTprLn7-OF-dXjSWI54bJig21ioCtGu5RR1mLbMY2qEdDJGy6yVvBemx6HuLpOoMtQPlSImeW2XocXW-l-2D2ek5uqm40ME4fXsQ4kabmJ0dQVvCoVfA26LGaM8MaRmmTBKQwzBIXLS-7rXmpZugt-Bz6coT0ac33m31JlxpIUirWlkEPt0JxPB3gZT15JKFcTQewpI0YVwhRTlhBfrxGXQXluhLpwpKlNm0RKiC-vDY0YOV--EVANkDbAwpRRgeIBjpm5DofUh0CYm-DYkWhSSfkazL5mZo5VdufJlK99RU3vEbiP9tv8D6Bywjz_M |
| CitedBy_id | crossref_primary_10_1177_10406387231210489 crossref_primary_10_7554_eLife_94056_3 crossref_primary_10_15252_embr_202357912 crossref_primary_10_1002_path_5842 crossref_primary_10_1038_s41591_021_01329_2 crossref_primary_10_3748_wjg_v27_i34_5630 crossref_primary_10_1371_journal_pcbi_1010773 crossref_primary_10_3389_fendo_2023_1128622 crossref_primary_10_1371_journal_pcbi_1011222 crossref_primary_10_3390_antiox12010172 crossref_primary_10_1038_s43587_021_00114_7 crossref_primary_10_3389_fcimb_2021_765300 crossref_primary_10_1007_s10528_023_10453_2 crossref_primary_10_1371_journal_pbio_3001805 crossref_primary_10_1016_j_jare_2024_07_033 crossref_primary_10_3390_v15020290 crossref_primary_10_1084_jem_20210220 crossref_primary_10_1016_j_ebiom_2023_104608 crossref_primary_10_1016_j_ebiom_2023_104729 crossref_primary_10_1073_pnas_2105968118 crossref_primary_10_3389_fimmu_2023_1251067 crossref_primary_10_1016_j_biopha_2021_112107 crossref_primary_10_1183_13993003_01699_2023 crossref_primary_10_1093_ajcp_aqab087 crossref_primary_10_1164_rccm_202111_2606OC crossref_primary_10_1016_j_amjms_2025_06_003 crossref_primary_10_1093_bioadv_vbaf113 crossref_primary_10_3390_v15010104 crossref_primary_10_1038_s41746_021_00481_w crossref_primary_10_1007_s00428_021_03053_1 crossref_primary_10_1016_j_exer_2022_108975 crossref_primary_10_1371_journal_pbio_3001959 crossref_primary_10_1016_j_metabol_2022_155236 crossref_primary_10_1002_ddr_21982 crossref_primary_10_3390_ijms231911058 crossref_primary_10_3389_fimmu_2024_1273942 crossref_primary_10_3390_pharmaceutics13040488 crossref_primary_10_1172_JCI149412 crossref_primary_10_3233_CH_219111 crossref_primary_10_3389_fmicb_2021_676693 crossref_primary_10_1016_j_clim_2022_108991 crossref_primary_10_1073_pnas_2116668118 crossref_primary_10_1038_s41598_022_20087_w crossref_primary_10_1186_s12931_023_02653_6 crossref_primary_10_3390_v13122418 crossref_primary_10_1186_s10020_022_00467_8 crossref_primary_10_2174_1574893618666230605120640 crossref_primary_10_1089_omi_2022_0104 crossref_primary_10_3390_bios13070712 crossref_primary_10_3389_fcimb_2022_845368 crossref_primary_10_1038_s41467_023_36001_5 crossref_primary_10_1093_molehr_gaac035 crossref_primary_10_7554_eLife_94056 crossref_primary_10_1038_s41588_021_00955_3 crossref_primary_10_1093_qjmed_hcac229 crossref_primary_10_1038_s41467_021_26884_7 crossref_primary_10_3390_life12060887 crossref_primary_10_1038_s41541_021_00399_0 crossref_primary_10_1111_febs_16622 crossref_primary_10_1146_annurev_immunol_101721_061120 crossref_primary_10_1038_s41392_023_01414_7 crossref_primary_10_1038_s41587_025_02614_y crossref_primary_10_3390_life12030453 crossref_primary_10_1038_s41422_022_00775_y crossref_primary_10_1038_s41421_024_00734_4 crossref_primary_10_3748_wjg_v27_i21_2850 crossref_primary_10_3390_life11101056 crossref_primary_10_3389_fendo_2022_801260 crossref_primary_10_1016_j_drudis_2021_07_026 crossref_primary_10_1158_2326_6066_CIR_21_0675 crossref_primary_10_4049_jimmunol_2200079 crossref_primary_10_1371_journal_pbio_3001851 crossref_primary_10_1093_infdis_jiac313 crossref_primary_10_3389_fmicb_2022_824967 crossref_primary_10_1093_bib_bbab446 crossref_primary_10_1111_imr_13114 crossref_primary_10_1038_s42003_021_02167_1 crossref_primary_10_3389_fimmu_2022_978760 crossref_primary_10_1093_cvr_cvac139 crossref_primary_10_1128_CMR_00094_21 crossref_primary_10_1111_imm_13577 crossref_primary_10_1128_jvi_01705_21 crossref_primary_10_1038_s41598_022_20040_x crossref_primary_10_1111_imr_13112 crossref_primary_10_1002_jmv_28021 crossref_primary_10_3389_fimmu_2021_650331 crossref_primary_10_1002_jmv_29472 crossref_primary_10_1016_j_cophys_2023_100670 crossref_primary_10_1038_s41586_021_03475_6 crossref_primary_10_3390_pathogens12030480 crossref_primary_10_1016_j_mito_2023_01_005 crossref_primary_10_3390_su14063417 crossref_primary_10_3390_vaccines10050771 crossref_primary_10_1371_journal_pone_0274841 crossref_primary_10_1016_j_csbj_2022_08_043 crossref_primary_10_1016_j_humgen_2024_201292 crossref_primary_10_1002_advs_202503932 crossref_primary_10_1038_s42255_021_00347_1 crossref_primary_10_1111_bph_15461 crossref_primary_10_1111_jcmm_17622 crossref_primary_10_1038_s41577_022_00785_2 crossref_primary_10_1093_nar_gkad1187 crossref_primary_10_1080_17455030_2023_2186713 crossref_primary_10_1126_scitranslmed_abo5070 crossref_primary_10_1038_s41586_022_05542_y crossref_primary_10_1016_j_celrep_2022_111148 crossref_primary_10_1038_s41421_024_00733_5 crossref_primary_10_1128_JVI_00294_21 crossref_primary_10_1186_s12931_025_03152_6 crossref_primary_10_1371_journal_pcbi_1011050 crossref_primary_10_3389_frnar_2024_1334873 crossref_primary_10_1016_j_prp_2022_154000 crossref_primary_10_26508_lsa_202101226 crossref_primary_10_1038_s41592_024_02273_y crossref_primary_10_1093_lifemedi_lnac053 crossref_primary_10_1016_j_ebiom_2022_104193 crossref_primary_10_1038_s42003_023_05253_8 crossref_primary_10_1186_s40779_023_00471_x crossref_primary_10_1016_j_coviro_2021_08_004 crossref_primary_10_3390_biom12091273 crossref_primary_10_1038_s41467_024_45204_3 crossref_primary_10_3389_fmicb_2023_1192832 crossref_primary_10_4155_fmc_2023_0013 crossref_primary_10_51847_iW1DfVoXVw crossref_primary_10_1038_s41598_023_29588_8 crossref_primary_10_1038_s41598_025_11164_x crossref_primary_10_1186_s13059_023_03080_y crossref_primary_10_2147_HMER_S301979 crossref_primary_10_1016_j_ajog_2021_07_029 crossref_primary_10_1016_S2213_2600_21_00408_2 crossref_primary_10_1016_j_ebiom_2023_104945 crossref_primary_10_1016_j_isci_2023_108366 crossref_primary_10_1002_jmv_28847 crossref_primary_10_3390_jcm10163567 crossref_primary_10_1183_13993003_01881_2021 crossref_primary_10_3389_fimmu_2021_660019 |
| Cites_doi | 10.1016/j.cell.2020.04.035 10.1038/s41591-020-0901-9 10.1016/S0140-6736(20)30628-0 10.1016/j.cell.2020.02.052 10.1016/j.antiviral.2020.104811 10.1016/S0014-5793(99)01493-3 10.4049/jimmunol.177.10.7303 10.18632/oncotarget.11651 10.1016/j.immuni.2014.10.007 10.1038/s41587-020-0472-9 10.1126/science.abb7314 10.1126/science.abc8511 10.1016/j.chom.2020.04.017 10.1002/art.41285 10.1056/NEJMoa2001017 10.1038/s41375-020-0891-0 10.1016/j.cell.2020.05.042 10.1016/j.cell.2020.04.026 10.1016/S2665-9913(20)30277-0 10.1016/j.chom.2020.03.021 10.1038/s41423-020-0401-3 10.1016/S1473-3099(20)30434-5 10.1038/s41587-019-0114-2 10.1038/s41467-020-14626-0 10.1128/JVI.00714-13 10.1038/s41385-019-0188-7 10.1016/S0140-6736(20)30183-5 10.1074/jbc.M111.304758 10.1186/s13059-014-0550-8 10.1016/S0140-6736(20)31042-4 10.1016/j.jinf.2020.04.017 10.1007/s00109-016-1391-6 10.1016/j.celrep.2020.107863 10.1016/j.jaci.2020.05.008 10.1093/bioinformatics/bts635 10.1016/j.cell.2014.12.033 10.1016/j.jinf.2020.06.008 10.1056/NEJMoa2020283 10.1016/j.immuni.2019.03.009 10.1126/science.abc6027 10.1172/JCI137244 10.1371/journal.pone.0090003 10.1016/j.immuni.2020.06.024 10.1056/NEJMoa2028836 10.1084/jem.20201241 10.4049/jimmunol.159.11.5201 10.3389/fimmu.2020.01160 10.1101/2020.03.14.988345 10.1101/2020.08.04.235168 |
| ContentType | Journal Article |
| Copyright | The Author(s) 2020 The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: The Author(s) 2020 – notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | C6C AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7X7 7XB 88E 8AO 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABUWG AEUYN AFKRA ARAPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU COVID DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. LK8 M0S M1P M7P P5Z P62 P64 PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS RC3 SOI 7X8 5PM DOA |
| DOI | 10.1038/s41467-020-20139-7 |
| DatabaseName | Springer Nature OA Free Journals (Selected full-text) CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Bacteriology Abstracts (Microbiology B) Calcium & Calcified Tissue Abstracts Chemoreception Abstracts Ecology Abstracts Entomology Abstracts (Full archive) Environment Abstracts Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Nucleic Acids Abstracts Oncogenes and Growth Factors Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection ProQuest Central Essentials Biological Science Collection ProQuest Central Technology Collection (via ProQuest SciTech Premium Collection) Natural Science Collection Environmental Sciences and Pollution Management ProQuest One Coronavirus Research Database ProQuest Central Korea Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Premium Collection (via ProQuest) ProQuest Health & Medical Complete (Alumni) Biological Sciences ProQuest Health & Medical Collection Medical Database Biological Science Database ProQuest advanced technologies & aerospace journals ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts ProQuest Central Premium ProQuest One Academic (New) Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition ProQuest Central China Genetics Abstracts Environment Abstracts MEDLINE - Academic PubMed Central (Full Participant titles) Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database ProQuest Central Student Oncogenes and Growth Factors Abstracts ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection ProQuest Central China Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Natural Science Collection Health & Medical Research Collection Biological Science Collection Chemoreception Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) ProQuest Central (New) ProQuest Medical Library (Alumni) Advanced Technologies & Aerospace Collection ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Coronavirus Research Database ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Entomology Abstracts ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Engineering Research Database ProQuest One Academic Calcium & Calcified Tissue Abstracts ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) AIDS and Cancer Research Abstracts ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Immunology Abstracts Environment Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 2041-1723 |
| EndPage | 15 |
| ExternalDocumentID | oai_doaj_org_article_c26ed9e652d143d4a25413482e8fff81 PMC7725958 33298930 10_1038_s41467_020_20139_7 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) grantid: R01CA240924; 7R01AI081848-04 funderid: https://doi.org/10.13039/100000054 – fundername: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) – fundername: ACD/Biotechne, The MGH Research Scholars Program, The Pershing Square Sohn Prize—Mark Foundation Fellow, The V Foundation, SU2C-Lustgarten – fundername: NCI NIH HHS grantid: R01 CA240924 – fundername: ; – fundername: ; grantid: R01CA240924; 7R01AI081848-04 |
| GroupedDBID | --- 0R~ 39C 3V. 53G 5VS 70F 7X7 88E 8AO 8FE 8FG 8FH 8FI 8FJ AAHBH AAJSJ ABUWG ACGFO ACGFS ACIWK ACMJI ACPRK ACSMW ADBBV ADFRT ADMLS ADRAZ AENEX AEUYN AFKRA AFRAH AHMBA AJTQC ALIPV ALMA_UNASSIGNED_HOLDINGS AMTXH AOIJS ARAPS ASPBG AVWKF AZFZN BBNVY BCNDV BENPR BGLVJ BHPHI BPHCQ BVXVI C6C CCPQU DIK EBLON EBS EE. EMOBN F5P FEDTE FYUFA GROUPED_DOAJ HCIFZ HMCUK HVGLF HYE HZ~ KQ8 LK8 M1P M48 M7P M~E NAO O9- OK1 P2P P62 PIMPY PQQKQ PROAC PSQYO RNS RNT RNTTT RPM SNYQT SV3 TSG UKHRP AASML AAYXX AFFHD CITATION PHGZM PHGZT PJZUB PPXIY PQGLB CGR CUY CVF ECM EIF NPM 7QL 7QP 7QR 7SN 7SS 7ST 7T5 7T7 7TM 7TO 7XB 8FD 8FK AZQEC C1K COVID DWQXO FR3 GNUQQ H94 K9. P64 PKEHL PQEST PQUKI PRINS RC3 SOI 7X8 PUEGO 5PM |
| ID | FETCH-LOGICAL-c606t-4731acc92e3b56c0b1454c1e5f5fa288bd86572d17ddc089ba3cf36097d6c9a3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 122 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000600149200012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 2041-1723 |
| IngestDate | Fri Oct 03 12:50:25 EDT 2025 Tue Nov 04 01:50:02 EST 2025 Sun Aug 24 03:37:02 EDT 2025 Tue Oct 07 06:54:40 EDT 2025 Thu Apr 03 06:59:12 EDT 2025 Tue Nov 18 21:36:31 EST 2025 Sat Nov 29 06:20:35 EST 2025 Fri Feb 21 02:40:10 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Language | English |
| License | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c606t-4731acc92e3b56c0b1454c1e5f5fa288bd86572d17ddc089ba3cf36097d6c9a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0003-4951-9914 0000-0002-2844-5883 0000-0002-3261-2322 0000-0001-9122-3311 0000-0003-2983-7704 0000-0002-2349-2656 0000-0002-4493-4150 0000-0002-9532-9735 0000-0003-4230-9308 |
| OpenAccessLink | https://doaj.org/article/c26ed9e652d143d4a25413482e8fff81 |
| PMID | 33298930 |
| PQID | 2473295279 |
| PQPubID | 546298 |
| PageCount | 15 |
| ParticipantIDs | doaj_primary_oai_doaj_org_article_c26ed9e652d143d4a25413482e8fff81 pubmedcentral_primary_oai_pubmedcentral_nih_gov_7725958 proquest_miscellaneous_2469093624 proquest_journals_2473295279 pubmed_primary_33298930 crossref_primary_10_1038_s41467_020_20139_7 crossref_citationtrail_10_1038_s41467_020_20139_7 springer_journals_10_1038_s41467_020_20139_7 |
| PublicationCentury | 2000 |
| PublicationDate | 2020-12-09 |
| PublicationDateYYYYMMDD | 2020-12-09 |
| PublicationDate_xml | – month: 12 year: 2020 text: 2020-12-09 day: 09 |
| PublicationDecade | 2020 |
| PublicationPlace | London |
| PublicationPlace_xml | – name: London – name: England |
| PublicationTitle | Nature communications |
| PublicationTitleAbbrev | Nat Commun |
| PublicationTitleAlternate | Nat Commun |
| PublicationYear | 2020 |
| Publisher | Nature Publishing Group UK Nature Publishing Group Nature Portfolio |
| Publisher_xml | – name: Nature Publishing Group UK – name: Nature Publishing Group – name: Nature Portfolio |
| References | Merritt (CR23) 2020; 38 Newman (CR49) 2019; 37 Zheng (CR45) 2020; 17 Ong (CR4) 2020; 27 Chen (CR11) 2020; 130 Mehta (CR9) 2020; 395 Zhu (CR1) 2020; 382 CR37 Cantini (CR29) 2020; 81 Hoffmann (CR13) 2020; 181 CR31 Herold (CR35) 2020; 146 Stanifer (CR24) 2020; 32 Biran (CR18) 2020; 2 Rooney, Shukla, Wu, Getz, Hacohen (CR16) 2015; 160 Hung (CR26) 2020; 395 Paget (CR39) 2012; 287 Minako Ito, Makoto, Nakamura, Yanagi, Ohno (CR42) 2013; 87 Ellinghaus (CR21) 2020; 383 Mantlo, Bukreyeva, Maruyama, Paessler, Huang (CR25) 2020; 179 Lo, Sogaard, Karlin (CR41) 2014; 9 Grifoni (CR17) 2020; 81 CR19 Huang (CR8) 2020; 395 Rockx (CR34) 2020; 368 CR14 Abood (CR20) 2019; 12 Perusina Lanfranca, Lin, Fang, Zou, Frankel (CR38) 2016; 94 Carsana (CR2) 2020; 20 Hadjadj (CR6) 2020; 369 CR50 Satoh-Takayama (CR22) 2014; 41 Ziegler (CR15) 2020; 181 La Rosée (CR30) 2020; 34 Martinez, Gordon, Locati, Mantovani (CR43) 2006; 177 Love, Huber, Anders (CR48) 2014; 15 Hou (CR32) 2020; 182 Richard (CR33) 2020; 11 Dobin (CR47) 2013; 29 Youn (CR44) 1997; 159 Schultheiß (CR7) 2020; 53 CR28 Liao (CR3) 2020; 26 Zhou (CR27) 2020; 27 Blanco-Melo (CR5) 2020; 181 Henderson (CR12) 2020; 72 Chuman (CR10) 1999; 462 Peng (CR40) 2016; 7 Sciascia (CR36) 2020; 38 Mathew (CR46) 2020; 369 Zilionis (CR51) 2019; 50 F Cantini (20139_CR29) 2020; 81 G Chen (20139_CR11) 2020; 130 IF-N Hung (20139_CR26) 2020; 395 M Liao (20139_CR3) 2020; 26 LA Henderson (20139_CR12) 2020; 72 T Herold (20139_CR35) 2020; 146 Z Zhou (20139_CR27) 2020; 27 MK Lo (20139_CR41) 2014; 9 C Peng (20139_CR40) 2016; 7 P Mehta (20139_CR9) 2020; 395 HY Zheng (20139_CR45) 2020; 17 MI Minako Ito (20139_CR42) 2013; 87 E Mantlo (20139_CR25) 2020; 179 N Satoh-Takayama (20139_CR22) 2014; 41 C Huang (20139_CR8) 2020; 395 RN Abood (20139_CR20) 2019; 12 20139_CR50 M Perusina Lanfranca (20139_CR38) 2016; 94 20139_CR14 20139_CR19 BS Youn (20139_CR44) 1997; 159 EZ Ong (20139_CR4) 2020; 27 MS Rooney (20139_CR16) 2015; 160 AM Newman (20139_CR49) 2019; 37 ML Stanifer (20139_CR24) 2020; 32 S Sciascia (20139_CR36) 2020; 38 FO Martinez (20139_CR43) 2006; 177 CR Merritt (20139_CR23) 2020; 38 M Hoffmann (20139_CR13) 2020; 181 E Grifoni (20139_CR17) 2020; 81 20139_CR28 J Hadjadj (20139_CR6) 2020; 369 MI Love (20139_CR48) 2014; 15 C Schultheiß (20139_CR7) 2020; 53 N Zhu (20139_CR1) 2020; 382 L Carsana (20139_CR2) 2020; 20 D Ellinghaus (20139_CR21) 2020; 383 F La Rosée (20139_CR30) 2020; 34 N Biran (20139_CR18) 2020; 2 D Mathew (20139_CR46) 2020; 369 Y Chuman (20139_CR10) 1999; 462 A Dobin (20139_CR47) 2013; 29 R Zilionis (20139_CR51) 2019; 50 20139_CR31 CGK Ziegler (20139_CR15) 2020; 181 B Rockx (20139_CR34) 2020; 368 C Paget (20139_CR39) 2012; 287 20139_CR37 YJ Hou (20139_CR32) 2020; 182 M Richard (20139_CR33) 2020; 11 D Blanco-Melo (20139_CR5) 2020; 181 32766600 - medRxiv. 2020 Aug 02 |
| References_xml | – volume: 181 start-page: 1016 year: 2020 end-page: 1035 e1019 ident: CR15 article-title: SARS-CoV-2 Receptor ACE2 Is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues publication-title: Cell doi: 10.1016/j.cell.2020.04.035 – volume: 26 start-page: 842 year: 2020 end-page: 844 ident: CR3 article-title: Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19 publication-title: Nat. Med. doi: 10.1038/s41591-020-0901-9 – volume: 159 start-page: 5201 year: 1997 end-page: 5205 ident: CR44 article-title: Molecular cloning of leukotactin-1: a novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3 publication-title: J. Immunol. – volume: 395 start-page: 1033 year: 2020 end-page: 1034 ident: CR9 article-title: COVID-19: consider cytokine storm syndromes and immunosuppression publication-title: Lancet doi: 10.1016/S0140-6736(20)30628-0 – volume: 181 start-page: 271 year: 2020 end-page: 280 e278 ident: CR13 article-title: SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor publication-title: Cell doi: 10.1016/j.cell.2020.02.052 – volume: 179 start-page: 104811 year: 2020 ident: CR25 article-title: Antiviral activities of type I interferons to SARS-CoV-2 infection publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2020.104811 – volume: 462 start-page: 129 year: 1999 end-page: 134 ident: CR10 article-title: Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)01493-3 – volume: 177 start-page: 7303 year: 2006 end-page: 7311 ident: CR43 article-title: Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression publication-title: J. Immunol. doi: 10.4049/jimmunol.177.10.7303 – volume: 7 start-page: 66822 year: 2016 end-page: 66834 ident: CR40 article-title: Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma publication-title: Oncotarget doi: 10.18632/oncotarget.11651 – volume: 41 start-page: 776 year: 2014 end-page: 788 ident: CR22 article-title: The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells publication-title: Immunity doi: 10.1016/j.immuni.2014.10.007 – ident: CR19 – volume: 38 start-page: 586 year: 2020 end-page: 599 ident: CR23 article-title: Multiplex digital spatial profiling of proteins and RNA in fixed tissue publication-title: Nat. Biotechnol doi: 10.1038/s41587-020-0472-9 – volume: 368 start-page: 1012 year: 2020 end-page: 1015 ident: CR34 article-title: Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model publication-title: Science doi: 10.1126/science.abb7314 – volume: 369 start-page: eabc8511 year: 2020 ident: CR46 article-title: Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications publication-title: Science doi: 10.1126/science.abc8511 – ident: CR50 – volume: 27 start-page: 883 year: 2020 end-page: 890 e882 ident: CR27 article-title: Heightened innate immune responses in the respiratory tract of COVID-19 patients publication-title: Cell Host Microbe doi: 10.1016/j.chom.2020.04.017 – volume: 72 start-page: 1059 year: 2020 end-page: 1063 ident: CR12 article-title: On the alert for cytokine storm: immunopathology in COVID-19 publication-title: Arthritis Rheumatol. doi: 10.1002/art.41285 – volume: 382 start-page: 727 year: 2020 end-page: 733 ident: CR1 article-title: A novel coronavirus from patients with pneumonia in China, 2019 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2001017 – volume: 34 start-page: 1805 year: 2020 end-page: 1815 ident: CR30 article-title: The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation publication-title: Leukemia doi: 10.1038/s41375-020-0891-0 – volume: 182 start-page: 429 year: 2020 end-page: 446.e414 ident: CR32 article-title: SARS-CoV-2 reverse genetics reveals a variable infection gradient in the respiratory tract publication-title: Cell doi: 10.1016/j.cell.2020.05.042 – volume: 181 start-page: 1036 year: 2020 end-page: 1045 e1039 ident: CR5 article-title: Imbalanced host response to SARS-CoV-2 drives development of COVID-19 publication-title: Cell doi: 10.1016/j.cell.2020.04.026 – volume: 2 start-page: e603 year: 2020 end-page: e612 ident: CR18 article-title: Tocilizumab among patients with COVID-19 in the intensive care unit: a multicentre observational study publication-title: Lancet Rheumatol. doi: 10.1016/S2665-9913(20)30277-0 – volume: 27 start-page: 879 year: 2020 end-page: 882 e872 ident: CR4 article-title: A dynamic immune response shapes COVID-19 progression publication-title: Cell Host Microbe doi: 10.1016/j.chom.2020.03.021 – volume: 17 start-page: 541 year: 2020 end-page: 543 ident: CR45 article-title: Elevated exhaustion levels and reduced functional diversity of T cells in peripheral blood may predict severe progression in COVID-19 patients publication-title: Cell Mol. Immunol. doi: 10.1038/s41423-020-0401-3 – volume: 20 start-page: 1135 year: 2020 end-page: 1140 ident: CR2 article-title: Pulmonary post-mortem findings in a series of COVID-19 cases from northern Italy: a two-centre descriptive study publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(20)30434-5 – ident: CR14 – ident: CR37 – volume: 37 start-page: 773 year: 2019 end-page: 782 ident: CR49 article-title: Determining cell type abundance and expression from bulk tissues with digital cytometry publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0114-2 – volume: 11 year: 2020 ident: CR33 article-title: Influenza A viruses are transmitted via the air from the nasal respiratory epithelium of ferrets publication-title: Nature Communications doi: 10.1038/s41467-020-14626-0 – volume: 87 start-page: 9633 year: 2013 end-page: 9642 ident: CR42 article-title: Measles virus nonstructural C protein modulates viral RNA polymerase activity by interacting with host protein SHCBP1 publication-title: J. Virol. doi: 10.1128/JVI.00714-13 – volume: 12 start-page: 1231 year: 2019 end-page: 1243 ident: CR20 article-title: IL-22-binding protein exacerbates influenza, bacterial super-infection publication-title: Mucosal Immunol. doi: 10.1038/s41385-019-0188-7 – volume: 395 start-page: 497 year: 2020 end-page: 506 ident: CR8 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 38 start-page: 529 year: 2020 end-page: 532 ident: CR36 article-title: Pilot prospective open, single-arm multicentre study on off-label use of tocilizumab in patients with severe COVID-19 publication-title: Clin. Exp. Rheumatol. – volume: 287 start-page: 8816 year: 2012 end-page: 8829 ident: CR39 article-title: Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.304758 – volume: 15 year: 2014 ident: CR48 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 – volume: 395 start-page: 1695 year: 2020 end-page: 1704 ident: CR26 article-title: Triple combination of interferon beta-1b, lopinavir–ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial publication-title: Lancet doi: 10.1016/S0140-6736(20)31042-4 – volume: 81 start-page: 318 year: 2020 end-page: 356 ident: CR29 article-title: Baricitinib therapy in COVID-19: a pilot study on safety and clinical impact publication-title: J. Infect. doi: 10.1016/j.jinf.2020.04.017 – volume: 94 start-page: 523 year: 2016 end-page: 534 ident: CR38 article-title: Biological and pathological activities of interleukin-22 publication-title: J. Mol. Med. (Berl) doi: 10.1007/s00109-016-1391-6 – volume: 32 start-page: 107863 year: 2020 ident: CR24 article-title: Critical role of type III interferon in controlling SARS-CoV-2 infection in human intestinal epithelial cells publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.107863 – volume: 146 start-page: 128 year: 2020 end-page: 136.e124 ident: CR35 article-title: Elevated levels of IL-6 and CRP predict the need for mechanical ventilation in COVID-19 publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2020.05.008 – volume: 29 start-page: 15 year: 2013 end-page: 21 ident: CR47 article-title: STAR: ultrafast universal RNA-seq aligner publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – ident: CR31 – volume: 160 start-page: 48 year: 2015 end-page: 61 ident: CR16 article-title: Molecular and genetic properties of tumors associated with local immune cytolytic activity publication-title: Cell doi: 10.1016/j.cell.2014.12.033 – volume: 81 start-page: 452 year: 2020 end-page: 482 ident: CR17 article-title: Interleukin-6 as prognosticator in patients with COVID-19 publication-title: J. Infect. doi: 10.1016/j.jinf.2020.06.008 – volume: 383 start-page: 1522 year: 2020 end-page: 1534 ident: CR21 article-title: Genomewide association study of severe covid-19 with respiratory failure publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2020283 – volume: 50 start-page: 1317 year: 2019 end-page: 1334 e1310 ident: CR51 article-title: Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species publication-title: Immunity doi: 10.1016/j.immuni.2019.03.009 – volume: 369 start-page: 718 year: 2020 end-page: 724 ident: CR6 article-title: Impaired type I interferon activity and inflammatory responses in severe COVID-19 patients publication-title: Science doi: 10.1126/science.abc6027 – volume: 130 start-page: 2620 year: 2020 end-page: 2629 ident: CR11 article-title: Clinical and immunological features of severe and moderate coronavirus disease 2019 publication-title: J. Clin. Invest. doi: 10.1172/JCI137244 – ident: CR28 – volume: 9 start-page: e90003 year: 2014 ident: CR41 article-title: Evolution and structural organization of the C proteins of paramyxovirinae publication-title: PLoS ONE doi: 10.1371/journal.pone.0090003 – volume: 53 start-page: 442 year: 2020 end-page: 455 e444 ident: CR7 article-title: Next-generation sequencing of T and B cell receptor repertoires from COVID-19 patients showed signatures associated with severity of disease publication-title: Immunity doi: 10.1016/j.immuni.2020.06.024 – volume: 287 start-page: 8816 year: 2012 ident: 20139_CR39 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M111.304758 – volume: 369 start-page: eabc8511 year: 2020 ident: 20139_CR46 publication-title: Science doi: 10.1126/science.abc8511 – ident: 20139_CR37 doi: 10.1056/NEJMoa2028836 – volume: 368 start-page: 1012 year: 2020 ident: 20139_CR34 publication-title: Science doi: 10.1126/science.abb7314 – volume: 179 start-page: 104811 year: 2020 ident: 20139_CR25 publication-title: Antiviral Res. doi: 10.1016/j.antiviral.2020.104811 – volume: 181 start-page: 1036 year: 2020 ident: 20139_CR5 publication-title: Cell doi: 10.1016/j.cell.2020.04.026 – ident: 20139_CR31 doi: 10.1084/jem.20201241 – volume: 462 start-page: 129 year: 1999 ident: 20139_CR10 publication-title: FEBS Lett. doi: 10.1016/S0014-5793(99)01493-3 – volume: 383 start-page: 1522 year: 2020 ident: 20139_CR21 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2020283 – volume: 382 start-page: 727 year: 2020 ident: 20139_CR1 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2001017 – volume: 72 start-page: 1059 year: 2020 ident: 20139_CR12 publication-title: Arthritis Rheumatol. doi: 10.1002/art.41285 – volume: 146 start-page: 128 year: 2020 ident: 20139_CR35 publication-title: J. Allergy Clin. Immunol. doi: 10.1016/j.jaci.2020.05.008 – volume: 27 start-page: 879 year: 2020 ident: 20139_CR4 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2020.03.021 – volume: 53 start-page: 442 year: 2020 ident: 20139_CR7 publication-title: Immunity doi: 10.1016/j.immuni.2020.06.024 – volume: 181 start-page: 271 year: 2020 ident: 20139_CR13 publication-title: Cell doi: 10.1016/j.cell.2020.02.052 – volume: 34 start-page: 1805 year: 2020 ident: 20139_CR30 publication-title: Leukemia doi: 10.1038/s41375-020-0891-0 – volume: 32 start-page: 107863 year: 2020 ident: 20139_CR24 publication-title: Cell Rep. doi: 10.1016/j.celrep.2020.107863 – volume: 20 start-page: 1135 year: 2020 ident: 20139_CR2 publication-title: Lancet Infect. Dis. doi: 10.1016/S1473-3099(20)30434-5 – volume: 11 year: 2020 ident: 20139_CR33 publication-title: Nature Communications doi: 10.1038/s41467-020-14626-0 – volume: 9 start-page: e90003 year: 2014 ident: 20139_CR41 publication-title: PLoS ONE doi: 10.1371/journal.pone.0090003 – volume: 26 start-page: 842 year: 2020 ident: 20139_CR3 publication-title: Nat. Med. doi: 10.1038/s41591-020-0901-9 – volume: 130 start-page: 2620 year: 2020 ident: 20139_CR11 publication-title: J. Clin. Invest. doi: 10.1172/JCI137244 – volume: 81 start-page: 452 year: 2020 ident: 20139_CR17 publication-title: J. Infect. doi: 10.1016/j.jinf.2020.06.008 – volume: 395 start-page: 1033 year: 2020 ident: 20139_CR9 publication-title: Lancet doi: 10.1016/S0140-6736(20)30628-0 – volume: 12 start-page: 1231 year: 2019 ident: 20139_CR20 publication-title: Mucosal Immunol. doi: 10.1038/s41385-019-0188-7 – volume: 38 start-page: 586 year: 2020 ident: 20139_CR23 publication-title: Nat. Biotechnol doi: 10.1038/s41587-020-0472-9 – volume: 87 start-page: 9633 year: 2013 ident: 20139_CR42 publication-title: J. Virol. doi: 10.1128/JVI.00714-13 – volume: 395 start-page: 497 year: 2020 ident: 20139_CR8 publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 159 start-page: 5201 year: 1997 ident: 20139_CR44 publication-title: J. Immunol. doi: 10.4049/jimmunol.159.11.5201 – volume: 38 start-page: 529 year: 2020 ident: 20139_CR36 publication-title: Clin. Exp. Rheumatol. – volume: 160 start-page: 48 year: 2015 ident: 20139_CR16 publication-title: Cell doi: 10.1016/j.cell.2014.12.033 – volume: 37 start-page: 773 year: 2019 ident: 20139_CR49 publication-title: Nat. Biotechnol. doi: 10.1038/s41587-019-0114-2 – ident: 20139_CR19 doi: 10.3389/fimmu.2020.01160 – volume: 29 start-page: 15 year: 2013 ident: 20139_CR47 publication-title: Bioinformatics doi: 10.1093/bioinformatics/bts635 – volume: 177 start-page: 7303 year: 2006 ident: 20139_CR43 publication-title: J. Immunol. doi: 10.4049/jimmunol.177.10.7303 – volume: 395 start-page: 1695 year: 2020 ident: 20139_CR26 publication-title: Lancet doi: 10.1016/S0140-6736(20)31042-4 – volume: 369 start-page: 718 year: 2020 ident: 20139_CR6 publication-title: Science doi: 10.1126/science.abc6027 – volume: 2 start-page: e603 year: 2020 ident: 20139_CR18 publication-title: Lancet Rheumatol. doi: 10.1016/S2665-9913(20)30277-0 – ident: 20139_CR14 doi: 10.1101/2020.03.14.988345 – volume: 50 start-page: 1317 year: 2019 ident: 20139_CR51 publication-title: Immunity doi: 10.1016/j.immuni.2019.03.009 – volume: 94 start-page: 523 year: 2016 ident: 20139_CR38 publication-title: J. Mol. Med. (Berl) doi: 10.1007/s00109-016-1391-6 – ident: 20139_CR50 doi: 10.1101/2020.08.04.235168 – volume: 181 start-page: 1016 year: 2020 ident: 20139_CR15 publication-title: Cell doi: 10.1016/j.cell.2020.04.035 – volume: 81 start-page: 318 year: 2020 ident: 20139_CR29 publication-title: J. Infect. doi: 10.1016/j.jinf.2020.04.017 – volume: 15 year: 2014 ident: 20139_CR48 publication-title: Genome Biol doi: 10.1186/s13059-014-0550-8 – volume: 7 start-page: 66822 year: 2016 ident: 20139_CR40 publication-title: Oncotarget doi: 10.18632/oncotarget.11651 – volume: 17 start-page: 541 year: 2020 ident: 20139_CR45 publication-title: Cell Mol. Immunol. doi: 10.1038/s41423-020-0401-3 – ident: 20139_CR28 – volume: 27 start-page: 883 year: 2020 ident: 20139_CR27 publication-title: Cell Host Microbe doi: 10.1016/j.chom.2020.04.017 – volume: 182 start-page: 429 year: 2020 ident: 20139_CR32 publication-title: Cell doi: 10.1016/j.cell.2020.05.042 – volume: 41 start-page: 776 year: 2014 ident: 20139_CR22 publication-title: Immunity doi: 10.1016/j.immuni.2014.10.007 – reference: 32766600 - medRxiv. 2020 Aug 02;: |
| SSID | ssj0000391844 |
| Score | 2.6612947 |
| Snippet | The relationship of SARS-CoV-2 pulmonary infection and severity of disease is not fully understood. Here we show analysis of autopsy specimens from 24 patients... Understanding the pathology in the lungs of patients with COVID-19 might provide clues as to the susceptibility of patients and how the SARS-CoV-2 virus can be... |
| SourceID | doaj pubmedcentral proquest pubmed crossref springer |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 6319 |
| SubjectTerms | 13/51 13/56 38/77 38/88 38/90 38/91 692/308/575 692/699/255/2514 Adult Aged Aged, 80 and over Aspartic Acid Endopeptidases - metabolism Autopsies Autopsy Cadavers COVID-19 COVID-19 - immunology COVID-19 - metabolism Damage Epithelial cells Epithelial Cells - metabolism Epithelial Cells - pathology Epithelial Cells - virology Female Fibrosis Gene expression Genes Heterogeneity Host Microbial Interactions Humanities and Social Sciences Humans Immunity Immunohistochemistry In Situ Hybridization Infections Inflammation Interferon Interferons - genetics Interferons - metabolism Lung - pathology Lung - virology Lungs Macrophages Macrophages - immunology Male Middle Aged Mucin Mucins - genetics Mucins - metabolism multidisciplinary Patients Ribonucleic acid RNA Science Science (multidisciplinary) Severe acute respiratory syndrome coronavirus 2 Spatial heterogeneity Surface-Active Agents - metabolism Transcription activation Transcriptome Viral diseases Viral Load Viruses |
| SummonAdditionalLinks | – databaseName: ProQuest advanced technologies & aerospace journals dbid: P5Z link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Jb9UwELaggMSFfQkUZCRuYDXx7hMqFRWnqqIPVHGxvKWt9JQ8kveQ-u-xnaV6LL1wixJHGWdmPDOe8TcAvCXY1ZyQGjHDS0SjzUSqLD3yljKLhaec2dxsQhwdydNTdTxuuPVjWeW0JuaF2rcu7ZHvYSoIVgwL9WH1A6WuUSm7OrbQuAluJZSEpJjH7Pu8x5LQzyWl41mZksi9nuaVIcVMODk_SGzZowzb_zdf88-Syd_yptkcHd7_34k8APdGRxTuD5LzENwIzSNwZ2hNefkYfF0MmFVLaBoP-1R3Ha_PU_FMG2UuROcdtjVMZ0RgN9TZBrhu4cn-lxN00H5DGK42y_gt013CqeKreQIWh58WB5_R2IIBuRjZrFGktTLOKRyIZdyVtqKMuiqwmtUGS2m95ExgXwnvXSmVNcTVhJdKeO6UIU_BTtM24TmA0RxaI6I_KbiNTiBTkhliKmajPBBb-QJUEx-0G-HJU5eMpc5pciL1wDsdeacz77QowLv5ndUAznHt6I-JvfPIBKydb7TdmR71VDvMg1eBszgnSjw1MYCuEgBQkHVdy6oAuxNX9ajtvb5iaQHezI-jnqbki2lCu0ljuCpVdBdoAZ4NsjRTQkjCwSdlAcSWlG2Ruv2kuTjPWOAxOGKKyQK8n-Txiqx__4oX18_iJbiLk4qkqh21C3bW3Sa8Arfdz_VF373OOvYLq0osaA priority: 102 providerName: ProQuest |
| Title | Temporal and spatial heterogeneity of host response to SARS-CoV-2 pulmonary infection |
| URI | https://link.springer.com/article/10.1038/s41467-020-20139-7 https://www.ncbi.nlm.nih.gov/pubmed/33298930 https://www.proquest.com/docview/2473295279 https://www.proquest.com/docview/2469093624 https://pubmed.ncbi.nlm.nih.gov/PMC7725958 https://doaj.org/article/c26ed9e652d143d4a25413482e8fff81 |
| Volume | 11 |
| WOSCitedRecordID | wos000600149200012&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: DOA dateStart: 20150101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M~E dateStart: 20100101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: P5Z dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: M7P dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Health & Medical Collection customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: 7X7 dateStart: 20100101 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: BENPR dateStart: 20100101 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 2041-1723 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000391844 issn: 2041-1723 databaseCode: PIMPY dateStart: 20100101 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1La9wwEBZt2kIvoc_Uabqo0FsrYkvW65iEhPbQxSTbsu3F6GUSWOywj0L-fUeyd5vt89KLMZYMw6cZzQwafYPQG0ZdIxhrCDciJyX4TKLz3BNvS26p9KXgNjWbkOOxmk51davVV6wJ6-mBe-AOHRXB6yA49eDafWkgoykiI0tQTdOkS9cUop5byVTag5mG1KUcbsnkTB0uyrQnxGyJxrCHyC1PlAj7fxdl_los-dOJaXJEZ4_Q7hBB4qNe8sfoTmifoAd9T8mbp-jTpCebmmHTeryIBdPwfhmrXjpQlgBRN-4aHC934HlfIBvwssMXR-cX5KT7TCi-Xs1AOc38Bq9LtdpnaHJ2Ojl5T4beCcRBSrIkpWSFcU7TwCwXLrdFyUtXBN7wxlClrFeCS8BUeu9ypa1hrmEi19ILpw17jnbarg0vEAY_Zo2EQFAKC9Eb14obZgpuYSGZLXyGijWMtRt4xWN7i1mdzreZqnvoa4C-TtDXMkNvN_9c96waf519HFdnMzMyYqcPoCf1oCf1v_QkQwfrta0HM13UFGCimlOpM_R6MwwGFk9NTBu6VZwjdK7Bz5cZ2utVYSMJY5HAnuUZkltKsiXq9kh7dZlIvCGr4ZqrDL1bq9MPsf4Mxf7_gOIlekijHcSiHH2AdpbzVXiF7rtvy6vFfITuyqlMTzVC945Px9X5KBnXKNbFVvCs-FcYqT58rL58B1kzJPk |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9QwFH4qBQQX9iVQwEhwAquJl9g-IFQKVauWCtGhmpvl2A6tNEqGWUDzo_iP2FmmGpbeeuAWJY7l5XvP79mf3wN4QYktc0pLzE2eYhbWTKzS1GFXMF4Q4VjOiybZhDg8lMOh-rQGP_u7MJFW2evERlG72sY98k3CBCWKE6Hejr_hmDUqnq72KTRaWOz7xY_gsk3f7L0P8_uSkJ0Pg-1d3GUVwDYY6zMc6smMtYp4WvDcpkXGOLOZ5yUvDZGycDLngrhMOGdTqQpDbUnzVAmXW2VoqPYSXA5qXEQGmRiK5ZZODLYuGeuu5qRUbk5Zo4iii0airYXFyvLXZAn4m2n7J0Pzt2PaZvXbufmfjdstuNGZ2WirlYvbsOarO3C1Tby5uAtfBm1ErhEylUPTyCoPzyeRGlQHifLBNUF1ieINGDRpWcQezWp0tPX5CG_Xx5ig8XwUumYmC9Tz2ap7MLiILt2H9aqu_ENAYbEvjAjWssiLYOJyJbmhJuNFQDstMpdA1k-7tl3w9ZgDZKQbEgCVuoWKDlDRDVS0SODV8p9xG3rk3NLvIpqWJWPY8OZFPfmqOy2kLcm9Uz7noU-MOmYID0YMk8TLsixllsBGDyLd6bKpPkNQAs-Xn4MWikdLpvL1PJbJVaqCMcQSeNBCd9kSSmOUf5omIFZAvdLU1S_V6UkT6Ty4flxxmcDrHv5nzfr3UDw6vxfP4Nru4OOBPtg73H8M10mUzshPUhuwPpvM_RO4Yr_PTqeTp414I9AXLBa_AI4ViN0 |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Jb9QwFH4qZREXdkqggJHgBNEkXmL7gFBpGVEVjUZ0QFUvlmM7baVRMswCmp_Gv8POMtWw9NYDtyhxIjv53vP34s_vAbwk2BQZIUXMdJbE1M-ZsUwSG9ucshxzSzOW18Um-GAgjo7kcAN-dnthgqyy84m1o7aVCf_Ie5hygiXDXPaKVhYx3Ou_m3yLQwWpsNLaldNoIHLglj98-DZ7u7_nv_UrjPsfRrsf47bCQGw8cZ_H_pmpNkZiR3KWmSRPKaMmdaxghcZC5FZkjGObcmtNImSuiSlIlkhuMyM18Y-9Ale5DzFD3Ddkx6vfOyHxuqC03aaTENGb0dophXANB94V87WpsK4Y8Dea-6da87cl23om7N_-j9_hHbjV0m-009jLXdhw5T243hTkXN6HL6MmU9cY6dKiWVCb--PTIBmqvKU5H7KgqkBhZwyaNupih-YVOtz5fBjvVl9jjCaLsR-ani5Rp3MrH8DoMob0EDbLqnSPAHkSkGvuWTTPck99mRRME52y3FsByVMbQdpBQJk2KXuoDTJWtTiACNXARnnYqBo2ikfwenXPpElJcmHr9wFZq5YhnXh9opqeqNY7KYMzZ6XLmB8TJZZqzDy5oQI7URSFSCPY7gClWh83U-doiuDF6rL3TmHJSZeuWoQ2mUykJ0k0gq0GxqueEBKy_5MkAr4G8LWurl8pz07rDOg-JGSSiQjedKZw3q1_v4rHF4_iOdzw1qA-7Q8OnsBNHAw1yJbkNmzOpwv3FK6Z7_Oz2fRZbekI1CVbxS_Ti5HQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Temporal+and+spatial+heterogeneity+of+host+response+to+SARS-CoV-2+pulmonary+infection&rft.jtitle=Nature+communications&rft.au=Desai%2C+Niyati&rft.au=Neyaz%2C+Azfar&rft.au=Szabolcs%2C+Annamaria&rft.au=Shih%2C+Angela+R.&rft.date=2020-12-09&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=11&rft_id=info:doi/10.1038%2Fs41467-020-20139-7&rft_id=info%3Apmid%2F33298930&rft.externalDocID=PMC7725958 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon |