Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?

Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine...

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Published in:	Cell death & disease Vol. 13; no. 7; pp. 580 - 16
Main Authors:	Kou, Meng, Huang, Li, Yang, Jinjuan, Chiang, Zhixin, Chen, Shaoxiang, Liu, Jie, Guo, Liyan, Zhang, Xiaoxian, Zhou, Xiaoya, Xu, Xiang, Yan, Xiaomei, Wang, Yan, Zhang, Jinqiu, Xu, Aimin, Tse, Hung-fat, Lian, Qizhou
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 04.07.2022 Springer Nature B.V Nature Publishing Group
Subjects:	13/100 631/532/2074 631/532/489 Adipocytes Adipose tissue Antibodies Antigens Arthritis Biochemistry Biomedical and Life Sciences Biosynthesis Body fat Body fluids Bone marrow Cell Biology Cell Culture Cell Differentiation Cell interactions Cell self-renewal Cell therapy Cell- and Tissue-Based Therapy Chemokines Communication Extracellular Vesicles FDA approval Fibrosis Growth factors Hospitals Immunogenicity Immunology Immunomodulation Immunoregulation Laboratories Life Sciences Lipids Mesenchymal Stem Cells Osteoarthritis Paracrine signalling Proteins Regeneration Review Review Article Spinal cord injuries Stem cells Therapeutic applications Tissue engineering Umbilical cord
ISSN:	2041-4889, 2041-4889
Online Access:	Get full text
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Abstract	Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity.
AbstractList	Abstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity.Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity.
ArticleNumber	580
Author	Guo, Liyan Yang, Jinjuan Chen, Shaoxiang Huang, Li Zhang, Xiaoxian Yan, Xiaomei Wang, Yan Chiang, Zhixin Liu, Jie Lian, Qizhou Kou, Meng Zhou, Xiaoya Zhang, Jinqiu Xu, Aimin Tse, Hung-fat Xu, Xiang
Author_xml	– sequence: 1 givenname: Meng surname: Kou fullname: Kou, Meng organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 2 givenname: Li surname: Huang fullname: Huang, Li organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 3 givenname: Jinjuan surname: Yang fullname: Yang, Jinjuan organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 4 givenname: Zhixin surname: Chiang fullname: Chiang, Zhixin organization: Department of Allied Health Sciences Faculty of Science, Tunku Abdul Rahman University – sequence: 5 givenname: Shaoxiang surname: Chen fullname: Chen, Shaoxiang organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 6 givenname: Jie surname: Liu fullname: Liu, Jie organization: State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong, Department of Medicine, the University of Hong Kong – sequence: 7 givenname: Liyan surname: Guo fullname: Guo, Liyan organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 8 givenname: Xiaoxian surname: Zhang fullname: Zhang, Xiaoxian organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 9 givenname: Xiaoya surname: Zhou fullname: Zhou, Xiaoya organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 10 givenname: Xiang orcidid: 0000-0002-1026-2210 surname: Xu fullname: Xu, Xiang organization: Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University – sequence: 11 givenname: Xiaomei surname: Yan fullname: Yan, Xiaomei organization: Department of Chemical Biology, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University – sequence: 12 givenname: Yan surname: Wang fullname: Wang, Yan organization: Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University – sequence: 13 givenname: Jinqiu surname: Zhang fullname: Zhang, Jinqiu organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 14 givenname: Aimin orcidid: 0000-0002-0668-033X surname: Xu fullname: Xu, Aimin organization: State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong, Department of Medicine, the University of Hong Kong – sequence: 15 givenname: Hung-fat surname: Tse fullname: Tse, Hung-fat organization: Department of Medicine, the University of Hong Kong, HKUMed Laboratory of Cellular Therapeutics, the University of Hong Kong – sequence: 16 givenname: Qizhou orcidid: 0000-0001-8189-7160 surname: Lian fullname: Lian, Qizhou email: qzlian@hku.hk organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong, Department of Medicine, the University of Hong Kong, HKUMed Laboratory of Cellular Therapeutics, the University of Hong Kong, Department of Surgery, Shenzhen Hong Kong University Hospital
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35787632$$D View this record in MEDLINE/PubMed
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Snippet	Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for... Abstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the...
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SubjectTerms	13/100 631/532/2074 631/532/489 Adipocytes Adipose tissue Antibodies Antigens Arthritis Biochemistry Biomedical and Life Sciences Biosynthesis Body fat Body fluids Bone marrow Cell Biology Cell Culture Cell Differentiation Cell interactions Cell self-renewal Cell therapy Cell- and Tissue-Based Therapy Chemokines Communication Extracellular Vesicles FDA approval Fibrosis Growth factors Hospitals Immunogenicity Immunology Immunomodulation Immunoregulation Laboratories Life Sciences Lipids Mesenchymal Stem Cells Osteoarthritis Paracrine signalling Proteins Regeneration Review Review Article Spinal cord injuries Stem cells Therapeutic applications Tissue engineering Umbilical cord
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Title	Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?
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