Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool?
Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine...
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| Vydané v: | Cell death & disease Ročník 13; číslo 7; s. 580 - 16 |
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| Hlavní autori: | , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
| Vydavateľské údaje: |
London
Nature Publishing Group UK
04.07.2022
Springer Nature B.V Nature Publishing Group |
| Predmet: | |
| ISSN: | 2041-4889, 2041-4889 |
| On-line prístup: | Získať plný text |
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| Abstract | Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. |
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| AbstractList | Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. Abstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity.Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for self-renewal and multipotent differentiation. There is compelling evidence that the therapeutic effect of MSCs mainly depends on their paracrine action. Extracellular vesicles (EVs) are fundamental paracrine effectors of MSCs and play a crucial role in intercellular communication, existing in various body fluids and cell supernatants. Since MSC-derived EVs retain the function of protocells and have lower immunogenicity, they have a wide range of prospective therapeutic applications with advantages over cell therapy. We describe some characteristics of MSC-EVs, and discuss their role in immune regulation and regeneration, with emphasis on the molecular mechanism and application of MSC-EVs in the treatment of fibrosis and support tissue repair. We also highlight current challenges in the clinical application of MSC-EVs and potential ways to overcome the problem of quality heterogeneity. |
| ArticleNumber | 580 |
| Author | Guo, Liyan Yang, Jinjuan Chen, Shaoxiang Huang, Li Zhang, Xiaoxian Yan, Xiaomei Wang, Yan Chiang, Zhixin Liu, Jie Lian, Qizhou Kou, Meng Zhou, Xiaoya Zhang, Jinqiu Xu, Aimin Tse, Hung-fat Xu, Xiang |
| Author_xml | – sequence: 1 givenname: Meng surname: Kou fullname: Kou, Meng organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 2 givenname: Li surname: Huang fullname: Huang, Li organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 3 givenname: Jinjuan surname: Yang fullname: Yang, Jinjuan organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 4 givenname: Zhixin surname: Chiang fullname: Chiang, Zhixin organization: Department of Allied Health Sciences Faculty of Science, Tunku Abdul Rahman University – sequence: 5 givenname: Shaoxiang surname: Chen fullname: Chen, Shaoxiang organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 6 givenname: Jie surname: Liu fullname: Liu, Jie organization: State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong, Department of Medicine, the University of Hong Kong – sequence: 7 givenname: Liyan surname: Guo fullname: Guo, Liyan organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 8 givenname: Xiaoxian surname: Zhang fullname: Zhang, Xiaoxian organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 9 givenname: Xiaoya surname: Zhou fullname: Zhou, Xiaoya organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 10 givenname: Xiang orcidid: 0000-0002-1026-2210 surname: Xu fullname: Xu, Xiang organization: Department of Stem Cell & Regenerative Medicine, State Key Laboratory of Trauma, Burn and Combined Injury, Daping Hospital, Army Medical University – sequence: 11 givenname: Xiaomei surname: Yan fullname: Yan, Xiaomei organization: Department of Chemical Biology, The MOE Key Laboratory of Spectrochemical Analysis & Instrumentation, College of Chemistry and Chemical Engineering, Xiamen University – sequence: 12 givenname: Yan surname: Wang fullname: Wang, Yan organization: Xiamen Cardiovascular Hospital of Xiamen University, School of Medicine, Xiamen University – sequence: 13 givenname: Jinqiu surname: Zhang fullname: Zhang, Jinqiu organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University – sequence: 14 givenname: Aimin orcidid: 0000-0002-0668-033X surname: Xu fullname: Xu, Aimin organization: State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong, Department of Medicine, the University of Hong Kong – sequence: 15 givenname: Hung-fat surname: Tse fullname: Tse, Hung-fat organization: Department of Medicine, the University of Hong Kong, HKUMed Laboratory of Cellular Therapeutics, the University of Hong Kong – sequence: 16 givenname: Qizhou orcidid: 0000-0001-8189-7160 surname: Lian fullname: Lian, Qizhou email: qzlian@hku.hk organization: Cord Blood Bank Centre, Guangzhou Women and Children’s Medical Centre, Guangzhou Medical University, State Key Laboratory of Pharmaceutical Biotechnology, the University of Hong Kong, Department of Medicine, the University of Hong Kong, HKUMed Laboratory of Cellular Therapeutics, the University of Hong Kong, Department of Surgery, Shenzhen Hong Kong University Hospital |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/35787632$$D View this record in MEDLINE/PubMed |
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| Snippet | Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the potential for... Abstract Mesenchymal stem cells (MSCs) can be widely isolated from various tissues including bone marrow, umbilical cord, and adipose tissue, with the... |
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| Title | Mesenchymal stem cell-derived extracellular vesicles for immunomodulation and regeneration: a next generation therapeutic tool? |
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