Selective cell death in HIV-1-infected cells by DDX3 inhibitors leads to depletion of the inducible reservoir

An innovative approach to eliminate HIV-1-infected cells emerging out of latency, the major hurdle to HIV-1 cure, is to pharmacologically reactivate viral expression and concomitantly trigger intracellular pro-apoptotic pathways in order to selectively induce cell death (ICD) of infected cells, with...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 2475 - 20
Main Authors:	Rao, Shringar, Lungu, Cynthia, Crespo, Raquel, Steijaert, Thijs H., Gorska, Alicja, Palstra, Robert-Jan, Prins, Henrieke A. B., van Ijcken, Wilfred, Mueller, Yvonne M., van Kampen, Jeroen J. A., Verbon, Annelies, Katsikis, Peter D., Boucher, Charles A. B., Rokx, Casper, Gruters, Rob A., Mahmoudi, Tokameh
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 30.04.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/2 13/31 14/19 38/32 38/77 38/88 45/91 631/326/22/1295 631/326/596/1787 631/326/596/2564 631/80/82/23 82/1 82/80 Anti-Retroviral Agents - pharmacology Apoptosis Apoptosis - drug effects Apoptosis - genetics Azepines - chemistry Azepines - pharmacology Biotechnology CD4 antigen CD4-Positive T-Lymphocytes - drug effects CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Cell death Cell Death - drug effects Cell Death - genetics Cell lines Cell survival Cell Survival - drug effects Cell Survival - genetics DEAD-box RNA Helicases - antagonists & inhibitors DEAD-box RNA Helicases - chemistry DEAD-box RNA Helicases - metabolism Depletion Enzyme Inhibitors - pharmacology Gene expression HIV HIV Infections - genetics HIV Infections - immunology HIV Infections - metabolism HIV Infections - virology HIV-1 - drug effects HIV-1 - genetics HIV-1 - metabolism Human immunodeficiency virus Humanities and Social Sciences Humans Imidazoles - chemistry Imidazoles - pharmacology Immune system In Situ Hybridization, Fluorescence Inhibitors Interferon regulatory factor 3 Interferon Regulatory Factor-3 - metabolism Interferon-beta - metabolism Jurkat Cells Latency Lymphocytes Lymphocytes T Molecular Docking Simulation Mortality multidisciplinary Pharmacology Phosphorylation Polypeptides Quantitation Ribonucleic acid RNA RNA, Viral - metabolism Science Science (multidisciplinary) Single-Cell Analysis Survivin - metabolism Virus Activation - drug effects Virus Latency - drug effects Virus Replication - drug effects Virus Replication - genetics β-Interferon
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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