Macrophage ATP citrate lyase deficiency stabilizes atherosclerotic plaques

Macrophages represent a major immune cell population in atherosclerotic plaques and play central role in the progression of this lipid-driven chronic inflammatory disease. Targeting immunometabolism is proposed as a strategy to revert aberrant macrophage activation to improve disease outcome. Here,...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 6296 - 15
Main Authors:	Baardman, Jeroen, Verberk, Sanne G. S., van der Velden, Saskia, Gijbels, Marion J. J., van Roomen, Cindy P. P. A., Sluimer, Judith C., Broos, Jelle Y., Griffith, Guillermo R., Prange, Koen H. M., van Weeghel, Michel, Lakbir, Soufyan, Molenaar, Douwe, Meinster, Elisa, Neele, Annette E., Kooij, Gijs, de Vries, Helga E., Lutgens, Esther, Wellen, Kathryn E., de Winther, Menno P. J., Van den Bossche, Jan
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 08.12.2020 Nature Publishing Group Nature Portfolio
Subjects:	101/58 13/2 13/21 13/31 13/51 14 14/1 38 38/88 38/91 45 631/250/2504/342 64/60 692/699/75 Aged Animals Apoptosis Apoptosis - immunology Arteriosclerosis Atherosclerosis ATP Citrate (pro-S)-Lyase - antagonists & inhibitors ATP Citrate (pro-S)-Lyase - deficiency ATP Citrate (pro-S)-Lyase - genetics ATP citrate lyase Biosynthesis Cell activation Cholesterol Cholesterol - biosynthesis Collagen Collagen - metabolism Deregulation Diet, High-Fat - adverse effects Disease Models, Animal Dyslipidemia Fatty acids Fatty Acids - biosynthesis Female Fibrosis Gene Expression Profiling Humanities and Social Sciences Humans Immune system Inflammatory diseases Lipidomics Lipids Lipogenesis - immunology Liver X receptors Liver X Receptors - metabolism Macrophage Activation Macrophages Macrophages - immunology Macrophages - metabolism Male Mice, Knockout multidisciplinary Necrosis - immunology Necrosis - pathology Phagocytosis Phenotypes Plaque, Atherosclerotic - drug therapy Plaque, Atherosclerotic - immunology Plaque, Atherosclerotic - pathology Plaques Receptor mechanisms Science Science (multidisciplinary) Transcription
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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