Taxonomic signatures of cause-specific mortality risk in human gut microbiome

The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances...

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Veröffentlicht in:Nature communications Jg. 12; H. 1; S. 2671 - 8
Hauptverfasser: Salosensaari, Aaro, Laitinen, Ville, Havulinna, Aki S., Meric, Guillaume, Cheng, Susan, Perola, Markus, Valsta, Liisa, Alfthan, Georg, Inouye, Michael, Watrous, Jeramie D., Long, Tao, Salido, Rodolfo A., Sanders, Karenina, Brennan, Caitriona, Humphrey, Gregory C., Sanders, Jon G., Jain, Mohit, Jousilahti, Pekka, Salomaa, Veikko, Knight, Rob, Lahti, Leo, Niiranen, Teemu
Format: Journal Article
Sprache:Englisch
Veröffentlicht: London Nature Publishing Group UK 11.05.2021
Nature Publishing Group
Nature Portfolio
Schlagworte:
45/23
631/326/107
631/326/2565/2142
692/53/2422
Adolescent
Adult
Aged
Cause of Death - trends
Cohort Studies
Composition
Cross-Sectional Studies
Digestive system
Enterobacteriaceae
Enterobacteriaceae - classification
Enterobacteriaceae - genetics
Feces - microbiology
Female
Finland
Gastrointestinal Microbiome - genetics
Gut microbiota
Health risks
Humanities and Social Sciences
Humans
Intestinal microflora
Male
Microbiomes
Microbiota
Middle Aged
Mortality
Mortality risk
multidisciplinary
Population Surveillance - methods
Risk
Risk Factors
RNA, Ribosomal, 16S - genetics
Science
Science (multidisciplinary)
Signatures
Taxonomy
Young Adult
Finland
ISSN:2041-1723, 2041-1723
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Zusammenfassung:The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterised due to the lack of sufficiently large and representative population cohorts with comprehensive follow-up data. Here, we analyse the long-term association between gut microbiome variation and mortality in a well-phenotyped and representative population cohort from Finland ( n  = 7211). We report robust taxonomic and functional microbiome signatures related to the Enterobacteriaceae family that are associated with mortality risk during a 15-year follow-up. Our results extend previous cross-sectional studies, and help to establish the basis for examining long-term associations between human gut microbiome composition, incident outcomes, and general health status. Gut microbiome composition has a role in health and disease. Here the authors show that microbiome signatures related to the Enterobacteriaceae family are associated with cause-specific mortality risk in a well phenotyped Finish population over a 15-year follow-up.
Bibliographie:ObjectType-Article-1
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ObjectType-Feature-2
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ISSN:2041-1723
2041-1723
DOI:10.1038/s41467-021-22962-y