Serotonin signals through a gut-liver axis to regulate hepatic steatosis

Nonalcoholic fatty liver disease (NAFLD) is increasing in worldwide prevalence, closely tracking the obesity epidemic, but specific pharmaceutical treatments for NAFLD are lacking. Defining the key molecular pathways underlying the pathogenesis of NAFLD is essential for developing new drugs. Here we...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 4824 - 9
Main Authors:	Choi, Wonsuk, Namkung, Jun, Hwang, Inseon, Kim, Hyeongseok, Lim, Ajin, Park, Hye Jung, Lee, Hye Won, Han, Kwang-Hyub, Park, Seongyeol, Jeong, Ji-Seon, Bang, Geul, Kim, Young Hwan, Yadav, Vijay K., Karsenty, Gerard, Ju, Young Seok, Choi, Chan, Suh, Jae Myoung, Park, Jun Yong, Park, Sangkyu, Kim, Hail
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 16.11.2018 Nature Publishing Group Nature Portfolio
Subjects:	14 14/63 38 38/77 38/91 631/443/319/1642 64 64/60 692/4020/4021/1607/2750 Animals Diet, High-Fat - adverse effects Disease Models, Animal Energy balance Epidemics Fatty liver Gene Expression Profiling Gene Expression Regulation High fat diet Homeostasis Humanities and Social Sciences Humans Hypolipidemic Agents - pharmacology Insulin Resistance Intestinal Mucosa - metabolism Intestinal Mucosa - pathology Lipid Metabolism Liver Liver - metabolism Liver - pathology Liver diseases Male Mice Mice, Knockout multidisciplinary Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - pathology Non-alcoholic Fatty Liver Disease - prevention & control Pathogenesis Receptor, Serotonin, 5-HT2A - deficiency Receptor, Serotonin, 5-HT2A - genetics Rodents Science Science (multidisciplinary) Serotonin Serotonin - metabolism Serotonin Antagonists - pharmacology Signal Transduction Steatosis Succinates - pharmacology Tryptophan Hydroxylase - deficiency Tryptophan Hydroxylase - genetics
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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