Salmonella Typhimurium reprograms macrophage metabolism via T3SS effector SopE2 to promote intracellular replication and virulence

Salmonella Typhimurium establishes systemic infection by replicating in host macrophages. Here we show that macrophages infected with S . Typhimurium exhibit upregulated glycolysis and decreased serine synthesis, leading to accumulation of glycolytic intermediates. The effects on serine synthesis ar...

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Bibliographic Details
Published in:	Nature communications Vol. 12; no. 1; pp. 879 - 18
Main Authors:	Jiang, Lingyan, Wang, Peisheng, Song, Xiaorui, Zhang, Huan, Ma, Shuangshuang, Wang, Jingting, Li, Wanwu, Lv, Runxia, Liu, Xiaoqian, Ma, Shuai, Yan, Jiaqi, Zhou, Haiyan, Huang, Di, Cheng, Zhihui, Yang, Chen, Feng, Lu, Wang, Lei
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 09.02.2021 Nature Publishing Group Nature Portfolio
Subjects:	13/89 38/1 38/15 38/90 38/91 42/109 631/250/254 631/326/41/88 631/326/421 631/45/320 82/83 Accumulation Animals Bacteria Bacterial Proteins - genetics Bacterial Proteins - metabolism Carbon sources Disseminated infection Gene Expression Regulation, Bacterial Genomic Islands Glucose - metabolism Glyceric Acids - metabolism Glycolysis Guanine Nucleotide Exchange Factors - genetics Guanine Nucleotide Exchange Factors - metabolism Humanities and Social Sciences Intermediates Intracellular Lactic acid Macrophages Macrophages - metabolism Macrophages - microbiology Metabolism Mice multidisciplinary Pathogenicity Pathogens Pyruvic acid RAW 264.7 Cells Replication Salmonella Salmonella Typhimurium Salmonella typhimurium - growth & development Salmonella typhimurium - metabolism Salmonella typhimurium - pathogenicity Science Science (multidisciplinary) Serine Serine - biosynthesis Signal Transduction Synthesis Type III Secretion Systems - genetics Type III Secretion Systems - metabolism Virulence Virulence factors
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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