Analysis of PARP inhibitor toxicity by multidimensional fluorescence microscopy reveals mechanisms of sensitivity and resistance

Exploiting the full potential of anti-cancer drugs necessitates a detailed understanding of their cytotoxic effects. While standard omics approaches are limited to cell population averages, emerging single cell techniques currently lack throughput and are not applicable for compound screens. Here, w...

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Vydáno v:	Nature communications Ročník 9; číslo 1; s. 2678 - 16
Hlavní autoři:	Michelena, Jone, Lezaja, Aleksandra, Teloni, Federico, Schmid, Thomas, Imhof, Ralph, Altmeyer, Matthias
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London Nature Publishing Group UK 11.07.2018 Nature Publishing Group Nature Portfolio
Témata:	14 49 631/1647/245/2225 631/337/1427 631/80/2373 631/80/641/151 96 96/63 Cancer Cell cycle Cell Cycle - drug effects Cell Cycle - genetics Cell Line Cell Line, Tumor Cell Survival - drug effects Cell Survival - genetics Cytotoxicity Deoxyribonucleic acid DNA DNA Damage DNA Repair Drug Resistance - drug effects Drug Resistance - genetics Fluorescence Fluorescence microscopy Humanities and Social Sciences Humans Hypersensitivity Microscopy Microscopy, Fluorescence - methods multidisciplinary Phthalazines - pharmacology Piperazines - pharmacology Poly(ADP-ribose) polymerase Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Poly(ADP-ribose) Polymerases - genetics Poly(ADP-ribose) Polymerases - metabolism RNA Interference Science Science (multidisciplinary) Synergism Targeted cancer therapy Time-Lapse Imaging - methods Toxicity Trapping
ISSN:	2041-1723, 2041-1723
On-line přístup:	Získat plný text
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