Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?

For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the...

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Bibliographic Details
Published in:The Journal of infection Vol. 81; no. 5; pp. 816 - 846
Main Authors: Gousseff, Marie, Penot, Pauline, Gallay, Laure, Batisse, Dominique, Benech, Nicolas, Bouiller, Kevin, Collarino, Rocco, Conrad, Anne, Slama, Dorsaf, Joseph, Cédric, Lemaignen, Adrien, Lescure, François-Xavier, Levy, Bruno, Mahevas, Matthieu, Pozzetto, Bruno, Vignier, Nicolas, Wyplosz, Benjamin, Salmon, Dominique, Goehringer, Francois, Botelho-Nevers, Elisabeth
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01.11.2020
Elsevier
The British Infection Association. Published by Elsevier Ltd
Subjects:
Adult
Aged
Aged, 80 and over
Betacoronavirus
Betacoronavirus - genetics
Coronavirus Infections
Coronavirus Infections - physiopathology
Coronavirus Infections - virology
COVID-19
Female
Follow-Up Studies
Human health and pathology
Humans
Letter to the Editor
Life Sciences
Male
Microbiology and Parasitology
Middle Aged
Pandemics
Pneumonia, Viral
Pneumonia, Viral - physiopathology
Pneumonia, Viral - virology
Recurrence
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
RNA, Viral - blood
RNA, Viral - genetics
SARS-CoV-2
Young Adult
ISSN:0163-4453, 1532-2742, 1532-2742
Online Access:Get full text
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Summary:For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Correspondence-1
content type line 23
ObjectType-Undefined-3
PMCID: PMC7326402
all the authors contributed equally to this article.
ISSN:0163-4453
1532-2742
1532-2742
DOI:10.1016/j.jinf.2020.06.073