Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?

For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the...

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Veröffentlicht in:The Journal of infection Jg. 81; H. 5; S. 816 - 846
Hauptverfasser: Gousseff, Marie, Penot, Pauline, Gallay, Laure, Batisse, Dominique, Benech, Nicolas, Bouiller, Kevin, Collarino, Rocco, Conrad, Anne, Slama, Dorsaf, Joseph, Cédric, Lemaignen, Adrien, Lescure, François-Xavier, Levy, Bruno, Mahevas, Matthieu, Pozzetto, Bruno, Vignier, Nicolas, Wyplosz, Benjamin, Salmon, Dominique, Goehringer, Francois, Botelho-Nevers, Elisabeth
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England Elsevier Ltd 01.11.2020
Elsevier
The British Infection Association. Published by Elsevier Ltd
Schlagworte:
Adult
Aged
Aged, 80 and over
Betacoronavirus
Betacoronavirus - genetics
Coronavirus Infections
Coronavirus Infections - physiopathology
Coronavirus Infections - virology
COVID-19
Female
Follow-Up Studies
Human health and pathology
Humans
Letter to the Editor
Life Sciences
Male
Microbiology and Parasitology
Middle Aged
Pandemics
Pneumonia, Viral
Pneumonia, Viral - physiopathology
Pneumonia, Viral - virology
Recurrence
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
RNA, Viral - blood
RNA, Viral - genetics
SARS-CoV-2
Young Adult
ISSN:0163-4453, 1532-2742, 1532-2742
Online-Zugang:Volltext
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Abstract For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.
AbstractList For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.
For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11 virologically-confirmed COVID-19 patients having experienced a second clinically- and virologically-confirmed acute COVID-19 episode. According to the clinical history, we discuss either re-infection or reactivation hypothesis. Larger studies including further virological, immunological and epidemiologic data are needed to understand the mechanisms of these recurrences.
Author Salmon, Dominique
Wyplosz, Benjamin
Conrad, Anne
Joseph, Cédric
Lescure, François-Xavier
Lemaignen, Adrien
Pozzetto, Bruno
Bouiller, Kevin
Levy, Bruno
Goehringer, Francois
Botelho-Nevers, Elisabeth
Mahevas, Matthieu
Collarino, Rocco
Penot, Pauline
Gallay, Laure
Gousseff, Marie
Vignier, Nicolas
Benech, Nicolas
Batisse, Dominique
Slama, Dorsaf
Author_xml – sequence: 1
  givenname: Marie
  surname: Gousseff
  fullname: Gousseff, Marie
  email: marie.gousseff@ch-bretagne-atlantique.fr
  organization: Service de Medecine interne, Maladies Infectieuses, hematologie, Centre Hospitalier Bretagne Atlantique, 20, boulevard Maurice Guillaudot, 56000 Vannes, France
– sequence: 2
  givenname: Pauline
  surname: Penot
  fullname: Penot, Pauline
  email: pauline.penot@ght-gpne.fr
  organization: Hôpital intercommunal André Grégoire, groupement hospitalier Grand Paris Nord Est, 56, boulevard de la Boissière, 93100 Montreuil, France
– sequence: 3
  givenname: Laure
  surname: Gallay
  fullname: Gallay, Laure
  email: laure.gallay@chu-lyon.fr
  organization: Service Médecine Interne, Pr Hot, INMG CNRS UMR5310 INSERM U1217, Place d'arsonvaal, 69003 Lyon, France
– sequence: 4
  givenname: Dominique
  surname: Batisse
  fullname: Batisse, Dominique
  organization: Department of Infectious Diseases and Immunology, Cochin-Hôtel-Dieu Hospital, Publique –Hôpitaux de Paris (APHP), University of Paris. 1, place parvis Notre Dame, 75014 Paris, France
– sequence: 5
  givenname: Nicolas
  surname: Benech
  fullname: Benech, Nicolas
  email: nicolas.benech@chu-lyon.fr
  organization: Service des Maladies Infectieuses et Tropicales, Hôpital de La Croix-Rousse, Hospices Civils de Lyon, 103, Grande Rue de La Croix-Rousse, 69004 Lyon, France
– sequence: 6
  givenname: Kevin
  surname: Bouiller
  fullname: Bouiller, Kevin
  email: kbouiller@chu-besancon.fr
  organization: Department of infectious disease, University Hospital of Besançon, F-25000 Besançon, France
– sequence: 7
  givenname: Rocco
  surname: Collarino
  fullname: Collarino, Rocco
  email: rocco.collarino@aphp.fr
  organization: Service des Maladies infectieuses et tropicales, Assistance publique- hôpitaux de Paris, Centre hospitalier universitaire Bicêtre, 78 rue du général Leclerc, 94270 Le Kremlin-Bicêtre, France
– sequence: 8
  givenname: Anne
  surname: Conrad
  fullname: Conrad, Anne
  email: anne.conrad@chu-lyon.fr
  organization: Service des Maladies Infectieuses et Tropicales, Hôpital de La Croix-Rousse, Hospices Civils de Lyon, 103, Grande Rue de La Croix-Rousse, 69004 Lyon, France
– sequence: 9
  givenname: Dorsaf
  surname: Slama
  fullname: Slama, Dorsaf
  organization: Department of Infectious Diseases and Immunology, Cochin-Hôtel-Dieu Hospital, Assistance, Publique –Hôpitaux de Paris (APHP), University of Paris. 1, place parvis Notre Dame, 75014 Paris, France
– sequence: 10
  givenname: Cédric
  surname: Joseph
  fullname: Joseph, Cédric
  email: joseph.cedric@chu-amiens.fr
  organization: Service des Maladies Infectieuses et Tropicales, CHU Amiens-Picardie, Place Victor Pauchet 80054 Amiens, France
– sequence: 11
  givenname: Adrien
  surname: Lemaignen
  fullname: Lemaignen, Adrien
  email: adrien.lemaignen@univ-tours.fr
  organization: Service de Médecine Interne et Maladies Infectieuses, CHRU de Tours, Hôpital Bretonneau, Université de Tours, 2, Boulevard Tonnellé, 37000 Tours, France
– sequence: 12
  givenname: François-Xavier
  surname: Lescure
  fullname: Lescure, François-Xavier
  email: xavier.lescure@aphp.fr
  organization: AP-HP, Infectious and Tropical Diseases Department, Bichat-Claude Bernard University, Hospital, Paris, France
– sequence: 13
  givenname: Bruno
  surname: Levy
  fullname: Levy, Bruno
  organization: Service de Médecine Intensive et Reanimation Brabois, CHRU Nancy, Pôle Cardio-Médico-Chirurgical, Vandoeuvre-les-Nancy, INSERM U1116, Faculté de Médecine, Vandoeuvre-les-Nancy, and Université de Lorraine, France
– sequence: 14
  givenname: Matthieu
  surname: Mahevas
  fullname: Mahevas, Matthieu
  email: matthieu.mahevas@aphp.fr
  organization: Service de Médecine Interne, Centre Hospitalier Universitaire Henri-Mondor, Assistance Publique-Hôpitaux de Paris, Université Paris Est Créteil, Créteil, France. IMRB - U955 – INSERM Equipe n°2 "Transfusion et maladies du globule rouge" EFS Île-de-France, Hôpital Henri-Mondor, AP-HP, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France
– sequence: 15
  givenname: Bruno
  surname: Pozzetto
  fullname: Pozzetto, Bruno
  email: bruno.pozzetto@chu-st-etienne.fr
  organization: GIMAP (EA 3064), University of Saint-Etienne, University of Lyon, Faculty of Medicine of Saint-Etienne, 42023 cedex 02 Saint-Etienne, France
– sequence: 16
  givenname: Nicolas
  surname: Vignier
  fullname: Vignier, Nicolas
  organization: Groupe hospitalier Sud Ile de France & INSERM, Institut Pierre Louis d'Épidémiologie et de, Santé Publique (IPLESP), Sorbonne Université, Paris, France, 270 avenue Marc Jacquet, 77 000 Melun, France
– sequence: 17
  givenname: Benjamin
  surname: Wyplosz
  fullname: Wyplosz, Benjamin
  email: Benjamin.wyplosz@aphp.fr
  organization: Service des Maladies infectieuses et tropicales, Assistance publique- hôpitaux de Paris, Centre hospitalier universitaire Bicêtre, 78 rue du général Leclerc, 94270 Le Kremlin-Bicêtre, France
– sequence: 18
  givenname: Dominique
  surname: Salmon
  fullname: Salmon, Dominique
  email: Dominique.salmon@aphp.fr
  organization: Department of Infectious Diseases and Immunology, Cochin-Hôtel-Dieu Hospital, Assistance, Publique –Hôpitaux de Paris (APHP), University of Paris. 1, place parvis Notre Dame, 75014 Paris, France
– sequence: 19
  givenname: Francois
  surname: Goehringer
  fullname: Goehringer, Francois
  email: f.goehringer@chru-nancy.fr
  organization: Service de Maladies Infectieuses et Tropicales, Centre Régional Universitaire de Nancy, Hôpitaux de Brabois, Rue du Morvan, 54511 Vandoeuvre Lés Nancy, France
– sequence: 20
  givenname: Elisabeth
  surname: Botelho-Nevers
  fullname: Botelho-Nevers, Elisabeth
  email: elisabeth.botelho-nevers@chu-st-etienne.fr
  organization: Infectious Diseases Department, University Hospital of Saint-Etienne, 42055 cedex 02 Saint-Etienne, GIMAP (EA 3064), France
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32619697$$D View this record in MEDLINE/PubMed
https://hal.science/hal-03080302$$DView record in HAL
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ContentType Journal Article
Copyright 2020 The British Infection Association
Copyright © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. 2020 The British Infection Association
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– notice: licence_http://creativecommons.org/publicdomain/zero
– notice: 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved. 2020 The British Infection Association
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License Copyright © 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
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Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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Snippet For the first 3 months of COVID-19 pandemic, COVID-19 was expected to be an immunizing non-relapsing disease. We report a national case series of 11...
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SubjectTerms Adult
Aged
Aged, 80 and over
Betacoronavirus
Betacoronavirus - genetics
Coronavirus Infections
Coronavirus Infections - physiopathology
Coronavirus Infections - virology
COVID-19
Female
Follow-Up Studies
Human health and pathology
Humans
Letter to the Editor
Life Sciences
Male
Microbiology and Parasitology
Middle Aged
Pandemics
Pneumonia, Viral
Pneumonia, Viral - physiopathology
Pneumonia, Viral - virology
Recurrence
Retrospective Studies
Reverse Transcriptase Polymerase Chain Reaction
RNA, Viral
RNA, Viral - blood
RNA, Viral - genetics
SARS-CoV-2
Young Adult
Title Clinical recurrences of COVID-19 symptoms after recovery: Viral relapse, reinfection or inflammatory rebound?
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