Population-scale study of eRNA transcription reveals bipartite functional enhancer architecture

Enhancer RNAs (eRNA) are unstable non-coding RNAs, transcribed bidirectionally from active regulatory sequences, whose expression levels correlate with enhancer activity. We use capped-nascent-RNA sequencing to efficiently capture bidirectional transcription initiation across several human lymphobla...

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Bibliographic Details
Published in:	Nature communications Vol. 11; no. 1; pp. 5963 - 12
Main Authors:	Kristjánsdóttir, Katla, Dziubek, Alexis, Kang, Hyun Min, Kwak, Hojoong
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 24.11.2020 Nature Publishing Group Nature Portfolio
Subjects:	38/39 38/43 45/91 631/208/200 631/208/726/2102 631/208/729/743 Bias Binding Binding sites Cell Line Enhancer Elements, Genetic - genetics Enhancers Gene expression Gene Expression Regulation - genetics Gene mapping Gene sequencing Humanities and Social Sciences Humans Lymphoblastoid cell lines multidisciplinary Non-coding RNA Population Population studies Population-based studies Quantitative Trait Loci Regulatory sequences Regulatory Sequences, Ribonucleic Acid RNA polymerase RNA, Messenger - metabolism RNA, Untranslated - genetics Science Science (multidisciplinary) Transcription factors Transcription, Genetic
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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