Effects of Pharmacogenetics on the Pharmacokinetics and Pharmacodynamics of Tamoxifen
The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. T...
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| Vydáno v: | Clinical pharmacokinetics Ročník 54; číslo 8; s. 797 - 810 |
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| Jazyk: | angličtina |
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Springer International Publishing
01.08.2015
Springer Nature B.V |
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| ISSN: | 0312-5963, 1179-1926, 1179-1926 |
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| Abstract | The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and endoxifen. Therefore, polymorphisms in the genes encoding these enzymes are proposed to influence tamoxifen and active tamoxifen metabolites in the serum and consequently affect patient response rates. To tailor tamoxifen treatment, multiple studies have been performed to clarify the influence of polymorphisms on its pharmacokinetics and pharmacodynamics. Nevertheless, personalized treatment of tamoxifen based on genotyping has not yet met consensus. This article critically reviews the published data on the effect of various genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tamoxifen, and reviews the clinical implications of its findings. For each CYP enzyme, the influence of polymorphisms on pharmacokinetic and pharmacodynamic outcome measures is described throughout this review. No clear effects on pharmacokinetics and pharmacodynamics were seen for various polymorphisms in the CYP encoding genes
CYP2B6
,
CYP2C9
,
CYP2C19
and
CYP3A4/5
. For
CYP2D6
, there was a clear gene-exposure effect that was able to partially explain the interindividual variability in plasma concentrations of the pharmacologically most active metabolite endoxifen; however, a clear exposure-response effect remained controversial. These controversial findings and the partial contribution of genotype in explaining interindividual variability in plasma concentrations of, in particular, endoxifen, imply that tailored tamoxifen treatment may not be fully realized through pharmacogenetics of metabolizing enzymes alone. |
|---|---|
| AbstractList | The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and endoxifen. Therefore, polymorphisms in the genes encoding these enzymes are proposed to influence tamoxifen and active tamoxifen metabolites in the serum and consequently affect patient response rates. To tailor tamoxifen treatment, multiple studies have been performed to clarify the influence of polymorphisms on its pharmacokinetics and pharmacodynamics. Nevertheless, personalized treatment of tamoxifen based on genotyping has not yet met consensus. This article critically reviews the published data on the effect of various genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tamoxifen, and reviews the clinical implications of its findings. For each CYP enzyme, the influence of polymorphisms on pharmacokinetic and pharmacodynamic outcome measures is described throughout this review. No clear effects on pharmacokinetics and pharmacodynamics were seen for various polymorphisms in the CYP encoding genes CYP2B6, CYP2C9, CYP2C19 and CYP3A4/5. For CYP2D6, there was a clear gene-exposure effect that was able to partially explain the interindividual variability in plasma concentrations of the pharmacologically most active metabolite endoxifen; however, a clear exposure-response effect remained controversial. These controversial findings and the partial contribution of genotype in explaining interindividual variability in plasma concentrations of, in particular, endoxifen, imply that tailored tamoxifen treatment may not be fully realized through pharmacogenetics of metabolizing enzymes alone.The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and endoxifen. Therefore, polymorphisms in the genes encoding these enzymes are proposed to influence tamoxifen and active tamoxifen metabolites in the serum and consequently affect patient response rates. To tailor tamoxifen treatment, multiple studies have been performed to clarify the influence of polymorphisms on its pharmacokinetics and pharmacodynamics. Nevertheless, personalized treatment of tamoxifen based on genotyping has not yet met consensus. This article critically reviews the published data on the effect of various genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tamoxifen, and reviews the clinical implications of its findings. For each CYP enzyme, the influence of polymorphisms on pharmacokinetic and pharmacodynamic outcome measures is described throughout this review. No clear effects on pharmacokinetics and pharmacodynamics were seen for various polymorphisms in the CYP encoding genes CYP2B6, CYP2C9, CYP2C19 and CYP3A4/5. For CYP2D6, there was a clear gene-exposure effect that was able to partially explain the interindividual variability in plasma concentrations of the pharmacologically most active metabolite endoxifen; however, a clear exposure-response effect remained controversial. These controversial findings and the partial contribution of genotype in explaining interindividual variability in plasma concentrations of, in particular, endoxifen, imply that tailored tamoxifen treatment may not be fully realized through pharmacogenetics of metabolizing enzymes alone. The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and endoxifen. Therefore, polymorphisms in the genes encoding these enzymes are proposed to influence tamoxifen and active tamoxifen metabolites in the serum and consequently affect patient response rates. To tailor tamoxifen treatment, multiple studies have been performed to clarify the influence of polymorphisms on its pharmacokinetics and pharmacodynamics. Nevertheless, personalized treatment of tamoxifen based on genotyping has not yet met consensus. This article critically reviews the published data on the effect of various genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tamoxifen, and reviews the clinical implications of its findings. For each CYP enzyme, the influence of polymorphisms on pharmacokinetic and pharmacodynamic outcome measures is described throughout this review. No clear effects on pharmacokinetics and pharmacodynamics were seen for various polymorphisms in the CYP encoding genes CYP2B6, CYP2C9, CYP2C19 and CYP3A4/5. For CYP2D6, there was a clear gene-exposure effect that was able to partially explain the interindividual variability in plasma concentrations of the pharmacologically most active metabolite endoxifen; however, a clear exposure-response effect remained controversial. These controversial findings and the partial contribution of genotype in explaining interindividual variability in plasma concentrations of, in particular, endoxifen, imply that tailored tamoxifen treatment may not be fully realized through pharmacogenetics of metabolizing enzymes alone. The antiestrogenic drug tamoxifen is widely used in the treatment of estrogen receptor-α-positive breast cancer and substantially decreases recurrence and mortality rates. However, high interindividual variability in response is observed, calling for a personalized approach to tamoxifen treatment. Tamoxifen is bioactivated by cytochrome P450 (CYP) enzymes such as CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4/5, resulting in the formation of active metabolites, including 4-hydroxy-tamoxifen and endoxifen. Therefore, polymorphisms in the genes encoding these enzymes are proposed to influence tamoxifen and active tamoxifen metabolites in the serum and consequently affect patient response rates. To tailor tamoxifen treatment, multiple studies have been performed to clarify the influence of polymorphisms on its pharmacokinetics and pharmacodynamics. Nevertheless, personalized treatment of tamoxifen based on genotyping has not yet met consensus. This article critically reviews the published data on the effect of various genetic polymorphisms on the pharmacokinetics and pharmacodynamics of tamoxifen, and reviews the clinical implications of its findings. For each CYP enzyme, the influence of polymorphisms on pharmacokinetic and pharmacodynamic outcome measures is described throughout this review. No clear effects on pharmacokinetics and pharmacodynamics were seen for various polymorphisms in the CYP encoding genes CYP2B6 , CYP2C9 , CYP2C19 and CYP3A4/5 . For CYP2D6 , there was a clear gene-exposure effect that was able to partially explain the interindividual variability in plasma concentrations of the pharmacologically most active metabolite endoxifen; however, a clear exposure-response effect remained controversial. These controversial findings and the partial contribution of genotype in explaining interindividual variability in plasma concentrations of, in particular, endoxifen, imply that tailored tamoxifen treatment may not be fully realized through pharmacogenetics of metabolizing enzymes alone. |
| Author | Linn, Sabine C. Beijnen, Jos H. de Vries Schultink, Aurelia H. M. Zwart, Wilbert Huitema, Alwin D. R. |
| Author_xml | – sequence: 1 givenname: Aurelia H. M. surname: de Vries Schultink fullname: de Vries Schultink, Aurelia H. M. organization: Department of Pharmacy and Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute – sequence: 2 givenname: Wilbert surname: Zwart fullname: Zwart, Wilbert organization: Division of Molecular Pathology, The Netherlands Cancer Institute – sequence: 3 givenname: Sabine C. surname: Linn fullname: Linn, Sabine C. organization: Division of Molecular Pathology, The Netherlands Cancer Institute, Department of Pathology, University Medical Center – sequence: 4 givenname: Jos H. surname: Beijnen fullname: Beijnen, Jos H. email: apjby@slz.nl organization: Department of Pharmacy and Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute, Division of Pharmacoepidemiology and Clinical Pharmacology, Science Faculty, Utrecht Institute for Pharmaceutical Sciences (UIPS), Utrecht University – sequence: 5 givenname: Alwin D. R. surname: Huitema fullname: Huitema, Alwin D. R. organization: Department of Pharmacy and Pharmacology, Antoni van Leeuwenhoek-The Netherlands Cancer Institute |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25940823$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/s10549-013-2511-4 10.1093/jjco/hyp076 10.1016/S1470-2045(09)70030-0 10.1038/clpt.2011.153 10.1007/s10549-012-2000-1 10.1046/j.1365-2125.2002.01614.x 10.1016/j.canlet.2004.10.007 10.1200/JCO.2009.25.7246 10.1093/jnci/djs126 10.7150/ijms.5708 10.1007/s10549-013-2585-z 10.1002/cncr.24111 10.1007/s10549-013-2568-0 10.1186/bcr2629 10.1158/1078-0432.CCR-12-2153 10.1111/j.1365-2125.2011.03905.x 10.1001/jama.2009.1420 10.1038/nrclinonc.2012.121 10.1200/JCO.2006.10.3523 10.1093/jnci/djs125 10.1016/S0140-6736(05)66544-0 10.1016/S1470-2045(11)70270-4 10.1111/j.1749-6632.1994.tb21761.x 10.1093/jnci/djt221 10.1185/03007995.2010.518304 10.1186/1471-2407-10-313 10.1056/NEJMra023246 10.1007/s00280-004-0926-7 10.1007/s10549-011-1425-2 10.1200/JCO.2005.03.3266 10.1038/clpt.2013.66 10.1007/s10552-014-0519-7 10.1016/j.clpt.2006.03.013 10.1093/jnci/djr010 10.1371/journal.pone.0070183 10.2217/pgs.11.97 10.1016/j.canlet.2004.08.027 10.1038/clpt.2011.32 10.1007/s00280-014-2453-5 10.1200/JCO.2005.09.121 10.1016/S0140-6736(11)60993-8 10.1007/s10549-013-2824-3 10.1038/clpt.2011.27 10.1200/JCO.2007.12.2705 10.1186/bcr993 10.1023/B:BREA.0000025406.31193.e8 10.1124/jpet.104.065607 10.1038/clpt.2014.96 10.3346/jkms.2011.26.8.1007 10.1038/clpt.2013.186 10.1007/s10549-004-7751-x 10.1111/bcp.12388 10.1158/1078-0432.CCR-10-0478 10.1093/annonc/mdn155 10.1200/JCO.2010.31.4427 10.1186/bcr1640 10.1093/jnci/dji005 10.1038/bjc.1984.163 10.1038/nrc3093 10.1007/s10549-011-1777-7 10.1111/j.1349-7006.2008.00780.x 10.1016/S0140-6736(12)61963-1 10.1093/annonc/mdm434 10.1200/jco.2013.31.18_suppl.5 10.1093/jnci/dju401 |
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| Keywords | Poor Metabolizer Tamoxifen Treatment Tamoxifen Therapeutic Drug Monitoring Overall Survival |
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| License | Open AccessThis article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
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| References | Desta, Ward, Soukhova, Flockhart (CR8) 2004; 310 Kiyotani, Mushiroda, Imamura, Tanigawara, Hosono, Kubo (CR67) 2012; 131 Winer, Hudis, Burstein, Wolff, Pritchard, Ingle (CR5) 2005; 23 Lash, Lien, Sørensen, Hamilton-Dutoit (CR56) 2009; 10 Jager, Rosing, Schellens, Linn, Beijnen (CR66) 2014; 143 Stingl, Parmar, Huber-Wechselberger, Kainz, Renner, Seeringer (CR44) 2010; 26 Wegman, Vainikka, Stål, Nordenskjöld, Skoog, Rutqvist (CR38) 2005; 7 Sismondi, Biglia, Volpi, Giai (CR70) 1994; 734 Schroth, Goetz, Hamann, Fasching, Schmidt, Winter (CR34) 2009; 302 Thomas, Gustafsson (CR11) 2011; 11 Beelen, Zwart, Linn (CR49) 2012; 9 Bratherton, Brown, Buchanan, Hall, Kingsley Pillers, Wheeler (CR69) 1984; 50 Berry (CR54) 2013; 105 Binkhorst, Mathijssen, van Herk-Sukel, Bannink, Jager, Wiemer (CR61) 2013; 139 Gjerde, Geisler, Lundgren, Ekse, Varhaug, Mellgren (CR59) 2010; 10 Rae, Drury, Hayes, Stearns, Thibert, Haynes (CR30) 2012; 104 Park, Ro, Park, Lim, Lee, Kang (CR46) 2012; 131 Jin, Desta, Stearns, Ward, Ho, Lee (CR19) 2005; 97 CR3 Smith, Dowsett (CR6) 2003; 348 Okishiro, Taguchi, Jin Kim, Shimazu, Tamaki, Noguchi (CR29) 2009; 115 Ter Heine, Binkhorst, de Graan, de Bruijn, Beijnen, Mathijssen (CR65) 2014; 78 Hudis, Barlow, Costantino, Gray, Pritchard, Chapman (CR51) 2007; 25 Lim, Desta, Flockhart, Skaar (CR9) 2005; 55 Gjerde, Hauglid, Breilid, Lundgren, Varhaug, Kisanga (CR42) 2008; 19 Toyama, Yamashita, Sugiura, Kondo, Iwase, Fujii (CR43) 2009; 39 Davies, Pan, Godwin, Gray, Arriagada, Raina (CR2) 2013; 381 Goetz, Suman, Hoskin, Gnant, Filipits, Safgren (CR18) 2013; 19 Berry (CR55) 2014; 96 Mürdter, Schroth, Bacchus-Gerybadze, Winter, Heinkele, Simon (CR26) 2011; 89 Moyer, Suman, Weinshilboum, Black, Safgren, Kuffel (CR25) 2011; 12 Abraham, Maranian, Driver, Platte, Kalmyrzaev, Baynes (CR45) 2010; 12 Park, Choi, Lee, Park, Yeo, Lee (CR47) 2011; 26 Tsuchiya, Nakajima, Yokoi (CR58) 2005; 227 Borges, Desta, Li, Skaar, Ward, Nguyen (CR14) 2006; 80 Xu, Sun, Yao, Shi, Wu, Ouyang (CR40) 2008; 19 Province, Goetz, Brauch, Flockhart, Hebert, Whaley (CR53) 2014; 95 (CR7) 2011; 378 Lash, Cronin-Fenton, Ahern, Rosenberg, Lunetta, Silliman (CR22) 2011; 103 Ratain, Nakamura, Cox (CR64) 2014; 94 Sensorn, Sirachainan, Chamnanphon, Pasomsub, Trachu, Supavilai (CR35) 2013; 6 Schroth, Antoniadou, Fritz, Schwab, Muerdter, Zanger (CR33) 2007; 25 Schroth, Hamann, Fasching, Dauser, Winter, Eichelbaum (CR63) 2010; 16 Fernández-Santander, Gaibar, Novillo, Romero-Lorca, Rubio, Chicharro (CR16) 2013; 8 Beelen, Opdam, Severson, Koornstra, Vincent, Hauptmann (CR13) 2013; 139 CR12 Tucker, Tkaczuk, Lewis, Tomic, Lim, Flaws (CR37) 2005; 217 Wegman, Elingarami, Carstensen, Stål, Nordenskjöld, Wingren (CR39) 2007; 9 Barginear, Jaremko, Peter, Yu, Kasai, Kemeny (CR48) 2011; 90 Chamnanphon, Pechatanan, Sirachainan, Trachu, Chantratita, Pasomsub (CR15) 2013; 6 CR50 Regan, Neven, Giobbie-Hurder, Goldhirsch, Ejlertsen, Mauriac (CR4) 2011; 12 Mwinyi, Vokinger, Jetter, Breitenstein, Hiller, Kullak-Ublick (CR27) 2014; 73 Kiyotani, Mushiroda, Imamura, Hosono, Tsunoda, Kubo (CR21) 2010; 28 Irvin, Walko, Weck, Ibrahim, Chiu, Dees (CR68) 2011; 29 Lim, Chen, Singh, Yap, Ng, Wong (CR23) 2011; 71 Kiyotani, Mushiroda, Sasa, Bando, Sumitomo, Hosono (CR20) 2008; 99 Regan, Leyland-Jones, Bouzyk, Pagani, Tang, Kammler (CR31) 2012; 104 (CR1) 2005; 365 Goetz, Rae, Suman, Safgren, Ames, Visscher (CR17) 2005; 23 Nowell, Ahn, Rae, Scheys, Trovato, Sweeney (CR28) 2005; 91 Blackburn, Ellsworth, Shriver, Ellsworth (CR57) 2015; 26 Jager, Rosing, Linn, Schellens, Beijnen (CR60) 2012; 133 Johnson, Zuo, Lee, Trebley, Rae, Weatherman (CR10) 2004; 85 Madlensky, Natarajan, Tchu, Pu, Mortimer, Flatt (CR24) 2011; 89 Saladores, Mürdter, Eccles, Chowbay, Zgheib, Winter (CR32) 2014; 1 Zafra-Ceres, de Haro, Farez-Vidal, Blancas, Bandres, de Dueñas (CR41) 2013; 10 CR62 Teft, Gong, Dingle, Potvin, Younus, Vandenberg (CR36) 2013; 139 Coller, Krebsfaenger, Klein, Endrizzi, Wolbold, Lang (CR52) 2002; 54 I Sensorn (273_CR35) 2013; 6 EP Winer (273_CR5) 2005; 23 A Fernández-Santander (273_CR16) 2013; 8 J Mwinyi (273_CR27) 2014; 73 273_CR50 MM Regan (273_CR4) 2011; 12 M Zafra-Ceres (273_CR41) 2013; 10 K Beelen (273_CR49) 2012; 9 R Heine Ter (273_CR65) 2014; 78 P Saladores (273_CR32) 2014; 1 JSL Lim (273_CR23) 2011; 71 K Kiyotani (273_CR67) 2012; 131 Early Breast Cancer Trialists’ Collaborative Group (273_CR7) 2011; 378 CA Hudis (273_CR51) 2007; 25 J Gjerde (273_CR42) 2008; 19 MF Barginear (273_CR48) 2011; 90 W Schroth (273_CR33) 2007; 25 D Bratherton (273_CR69) 1984; 50 L Madlensky (273_CR24) 2011; 89 Y Jin (273_CR19) 2005; 97 Z Desta (273_CR8) 2004; 310 MA Province (273_CR53) 2014; 95 MP Goetz (273_CR17) 2005; 23 T Toyama (273_CR43) 2009; 39 273_CR62 SA Nowell (273_CR28) 2005; 91 Early Breast Cancer Trialists’ Collaborative Group (273_CR1) 2005; 365 273_CR12 WJ Irvin (273_CR68) 2011; 29 K Kiyotani (273_CR21) 2010; 28 P Wegman (273_CR39) 2007; 9 C Davies (273_CR2) 2013; 381 273_CR3 S Borges (273_CR14) 2006; 80 AM Moyer (273_CR25) 2011; 12 MJ Ratain (273_CR64) 2014; 94 JM Rae (273_CR30) 2012; 104 HS Park (273_CR47) 2011; 26 M Chamnanphon (273_CR15) 2013; 6 WA Teft (273_CR36) 2013; 139 NL Jager (273_CR66) 2014; 143 MD Johnson (273_CR10) 2004; 85 MM Regan (273_CR31) 2012; 104 IE Smith (273_CR6) 2003; 348 W Schroth (273_CR34) 2009; 302 C Thomas (273_CR11) 2011; 11 P Sismondi (273_CR70) 1994; 734 JC Stingl (273_CR44) 2010; 26 NGL Jager (273_CR60) 2012; 133 L Binkhorst (273_CR61) 2013; 139 TE Mürdter (273_CR26) 2011; 89 JK Coller (273_CR52) 2002; 54 DA Berry (273_CR55) 2014; 96 HL Blackburn (273_CR57) 2015; 26 JE Abraham (273_CR45) 2010; 12 TL Lash (273_CR22) 2011; 103 K Kiyotani (273_CR20) 2008; 99 W Schroth (273_CR63) 2010; 16 TL Lash (273_CR56) 2009; 10 MP Goetz (273_CR18) 2013; 19 Y Xu (273_CR40) 2008; 19 D Berry (273_CR54) 2013; 105 Y Tsuchiya (273_CR58) 2005; 227 K Beelen (273_CR13) 2013; 139 P Wegman (273_CR38) 2005; 7 J Gjerde (273_CR59) 2010; 10 YC Lim (273_CR9) 2005; 55 AN Tucker (273_CR37) 2005; 217 M Okishiro (273_CR29) 2009; 115 IH Park (273_CR46) 2012; 131 21437611 - Breast Cancer Res Treat. 2012 Jan;131(2):455-61 15111773 - Breast Cancer Res Treat. 2004 May;85(2):151-9 16815318 - Clin Pharmacol Ther. 2006 Jul;80(1):61-74 23213055 - Clin Cancer Res. 2013 Jan 15;19(2):500-7 21768473 - J Clin Oncol. 2011 Aug 20;29(24):3232-9 20515869 - Clin Cancer Res. 2010 Sep 1;16(17):4468-77 25490892 - J Natl Cancer Inst. 2015 Feb;107(2). pii: dju401. doi: 10.1093/jnci/dju401 19156902 - Cancer. 2009 Mar 1;115(5):952-61 21947681 - Breast Cancer Res Treat. 2012 Jan;131(1):137-45 22018631 - Lancet Oncol. 2011 Nov;12(12):1101-8 15685451 - Cancer Chemother Pharmacol. 2005 May;55(5):471-8 15987423 - Breast Cancer Res. 2005;7(3):R284-90 22388692 - Breast Cancer Res Treat. 2012 Jun;133(2):793-8 20731819 - Breast Cancer Res. 2010;12(4):R64 23736997 - Breast Cancer Res Treat. 2013 Jun;139(3):649-55 21430657 - Clin Pharmacol Ther. 2011 May;89(5):718-25 24682508 - Cancer Chemother Pharmacol. 2014 Jun;73(6):1181-8 18024866 - J Clin Oncol. 2007 Nov 20;25(33):5187-93 24390246 - Breast Cancer Res Treat. 2014 Feb;143(3):477-83 23776391 - Pharmgenomics Pers Med. 2013 May 24;6:37-48 21900890 - Clin Pharmacol Ther. 2011 Oct;90(4):605-11 15159443 - J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75 15545664 - J Clin Oncol. 2005 Jan 20;23(3):619-29 20565970 - BMC Cancer. 2010;10:313 21451508 - Clin Pharmacol Ther. 2011 May;89(5):708-17 24697814 - Br J Clin Pharmacol. 2014 Sep;78(3):572-86 25554091 - Cancer Causes Control. 2015 Mar;26(3):319-32 15632378 - J Natl Cancer Inst. 2005 Jan 5;97(1):30-9 19647203 - Lancet Oncol. 2009 Aug;10(8):825-33 24019753 - Pharmgenomics Pers Med. 2013 Aug 26;6:93-8 23781139 - Int J Med Sci. 2013;10(7):932-7 6380554 - Br J Cancer. 1984 Aug;50(2):199-205 21802721 - Lancet. 2011 Aug 27;378(9793):771-84 15952058 - Breast Cancer Res Treat. 2005 Jun;91(3):249-58 19809024 - JAMA. 2009 Oct 7;302(13):1429-36 23219286 - Lancet. 2013 Mar 9;381(9869):805-16 7978932 - Ann N Y Acad Sci. 1994 Sep 30;734:310-21 21961651 - Pharmacogenomics. 2011 Nov;12(11):1535-43 22825374 - Nat Rev Clin Oncol. 2012 Sep;9(9):529-41 20849243 - Curr Med Res Opin. 2010 Nov;26(11):2535-42 21480951 - Br J Clin Pharmacol. 2011 May;71(5):737-50 22395643 - J Natl Cancer Inst. 2012 Mar 21;104(6):452-60 17244352 - Breast Cancer Res. 2007;9(1):R7 17513820 - J Clin Oncol. 2007 May 20;25(15):2127-32 22395644 - J Natl Cancer Inst. 2012 Mar 21;104(6):441-51 21325141 - J Natl Cancer Inst. 2011 Mar 16;103(6):489-500 20124171 - J Clin Oncol. 2010 Mar 10;28(8):1287-93 21779010 - Nat Rev Cancer. 2011 Aug;11(8):597-608 19596663 - Jpn J Clin Oncol. 2009 Oct;39(10):651-6 16361630 - J Clin Oncol. 2005 Dec 20;23(36):9312-8 18407954 - Ann Oncol. 2008 Aug;19(8):1423-9 16112414 - Cancer Lett. 2005 Sep 28;227(2):115-24 17947222 - Ann Oncol. 2008 Jan;19(1):56-61 21860550 - J Korean Med Sci. 2011 Aug;26(8):1007-13 23760858 - Breast Cancer Res Treat. 2013 Jun;139(3):923-9 25056391 - Clin Pharmacol Ther. 2014 Aug;96(2):138-40 18294285 - Cancer Sci. 2008 May;99(5):995-9 25091503 - Pharmacogenomics J. 2015 Feb;15(1):84-94 23958737 - J Natl Cancer Inst. 2013 Sep 4;105(17):1267-9 24060820 - Clin Pharmacol Ther. 2014 Feb;95(2):216-27 15894097 - Lancet. 2005 May 14-20;365(9472):1687-717 12207635 - Br J Clin Pharmacol. 2002 Aug;54(2):157-67 12802030 - N Engl J Med. 2003 Jun 12;348(24):2431-42 23922954 - PLoS One. 2013;8(7):e70183 15596297 - Cancer Lett. 2005 Jan 10;217(1):61-72 23580071 - Breast Cancer Res Treat. 2013 May;139(1):95-105 23872831 - Clin Pharmacol Ther. 2013 Aug;94(2):185-7 |
| References_xml | – volume: 139 start-page: 95 year: 2013 end-page: 105 ident: CR36 article-title: CYP3A4 and seasonal variation in vitamin D status in addition to CYP2D6 contribute to therapeutic endoxifen level during tamoxifen therapy publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-013-2511-4 – volume: 39 start-page: 651 year: 2009 end-page: 656 ident: CR43 article-title: No association between CYP2D6*10 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment publication-title: Jpn J Clin Oncol. doi: 10.1093/jjco/hyp076 – volume: 10 start-page: 825 year: 2009 end-page: 833 ident: CR56 article-title: Genotype-guided tamoxifen therapy: time to pause for reflection? publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(09)70030-0 – volume: 6 start-page: 37 year: 2013 end-page: 48 ident: CR15 article-title: Association of CYP2D6 and CYP2C19 polymorphisms and disease-free survival of Thai post-menopausal breast cancer patients who received adjuvant tamoxifen publication-title: Pharmgenomics Pers Med. – volume: 90 start-page: 605 year: 2011 end-page: 611 ident: CR48 article-title: Increasing tamoxifen dose in breast cancer patients based on CYP2D6 genotypes and endoxifen levels: effect on active metabolite isomers and the antiestrogenic activity score publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2011.153 – volume: 133 start-page: 793 year: 2012 end-page: 798 ident: CR60 article-title: Importance of highly selective LC–MS/MS analysis for the accurate quantification of tamoxifen and its metabolites: focus on endoxifen and 4-hydroxytamoxifen publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-012-2000-1 – ident: CR12 – volume: 54 start-page: 157 year: 2002 end-page: 167 ident: CR52 article-title: The influence of CYP2B6, CYP2C9 and CYP2D6 genotypes on the formation of the potent antioestrogen Z-4-hydroxy-tamoxifen in human liver publication-title: Br J Clin Pharmacol. doi: 10.1046/j.1365-2125.2002.01614.x – volume: 227 start-page: 115 year: 2005 end-page: 124 ident: CR58 article-title: Cytochrome P450-mediated metabolism of estrogens and its regulation in human publication-title: Cancer Lett. doi: 10.1016/j.canlet.2004.10.007 – volume: 28 start-page: 1287 year: 2010 end-page: 1293 ident: CR21 article-title: Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients publication-title: J Clin Oncol. doi: 10.1200/JCO.2009.25.7246 – volume: 104 start-page: 452 year: 2012 end-page: 460 ident: CR30 article-title: CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djs126 – volume: 10 start-page: 932 year: 2013 end-page: 937 ident: CR41 article-title: Influence of CYP2D6 polymorphisms on serum levels of tamoxifen metabolites in Spanish women with breast cancer publication-title: Int J Med Sci. doi: 10.7150/ijms.5708 – volume: 139 start-page: 923 year: 2013 end-page: 929 ident: CR61 article-title: Unjustified prescribing of CYP2D6 inhibiting SSRIs in women treated with tamoxifen publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-013-2585-z – volume: 115 start-page: 952 year: 2009 end-page: 961 ident: CR29 article-title: Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen publication-title: Cancer. doi: 10.1002/cncr.24111 – volume: 139 start-page: 649 year: 2013 end-page: 655 ident: CR13 article-title: CYP2C19 2 predicts substantial tamoxifen benefit in postmenopausal breast cancer patients randomized between adjuvant tamoxifen and no systemic treatment publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-013-2568-0 – volume: 12 start-page: R64 issue: 4 year: 2010 ident: CR45 article-title: CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen publication-title: Breast Cancer Res. doi: 10.1186/bcr2629 – volume: 19 start-page: 500 year: 2013 end-page: 507 ident: CR18 article-title: CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group Trial (ABCSG) 8 publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-12-2153 – volume: 71 start-page: 737 year: 2011 end-page: 750 ident: CR23 article-title: Impact of CYP2D6, CYP3A5, CYP2C9 and CYP2C19 polymorphisms on tamoxifen pharmacokinetics in Asian breast cancer patients publication-title: Br J Clin Pharmacol. doi: 10.1111/j.1365-2125.2011.03905.x – volume: 302 start-page: 1429 year: 2009 end-page: 1436 ident: CR34 article-title: Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen publication-title: JAMA. doi: 10.1001/jama.2009.1420 – volume: 9 start-page: 529 year: 2012 end-page: 541 ident: CR49 article-title: Can predictive biomarkers in breast cancer guide adjuvant endocrine therapy? publication-title: Nat Rev Clin Oncol. doi: 10.1038/nrclinonc.2012.121 – volume: 25 start-page: 2127 year: 2007 end-page: 2132 ident: CR51 article-title: Proposal for standardized definitions for efficacy end points in adjuvant breast cancer trials: the STEEP system publication-title: J Clin Oncol. doi: 10.1200/JCO.2006.10.3523 – volume: 104 start-page: 441 year: 2012 end-page: 451 ident: CR31 article-title: CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the Breast International Group 1-98 trial publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djs125 – ident: CR50 – volume: 365 start-page: 1687 year: 2005 end-page: 1717 ident: CR1 article-title: Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials publication-title: Lancet. doi: 10.1016/S0140-6736(05)66544-0 – volume: 12 start-page: 1101 year: 2011 end-page: 1108 ident: CR4 article-title: Assessment of letrozole and tamoxifen alone and in sequence for postmenopausal women with steroid hormone receptor-positive breast cancer: the BIG 1-98 randomised clinical trial at 8·1 years median follow-up publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(11)70270-4 – volume: 734 start-page: 310 year: 1994 end-page: 321 ident: CR70 article-title: Tamoxifen and endometrial cancer publication-title: Ann NY Acad Sci. doi: 10.1111/j.1749-6632.1994.tb21761.x – volume: 105 start-page: 1267 year: 2013 end-page: 1269 ident: CR54 article-title: CYP2D6 genotyping and the use of tamoxifen in breast cancer publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djt221 – volume: 26 start-page: 2535 year: 2010 end-page: 2542 ident: CR44 article-title: Impact of CYP2D6*4 genotype on progression free survival in tamoxifen breast cancer treatment publication-title: Curr Med Res Opin. doi: 10.1185/03007995.2010.518304 – volume: 10 start-page: 313 year: 2010 ident: CR59 article-title: Associations between tamoxifen, estrogens, and FSH serum levels during steady state tamoxifen treatment of postmenopausal women with breast cancer publication-title: BMC Cancer. doi: 10.1186/1471-2407-10-313 – volume: 348 start-page: 2431 year: 2003 end-page: 2442 ident: CR6 article-title: Aromatase inhibitors in breast cancer publication-title: N Engl J Med. doi: 10.1056/NEJMra023246 – volume: 55 start-page: 471 year: 2005 end-page: 478 ident: CR9 article-title: Endoxifen (4-hydroxy- -desmethyl-tamoxifen) has anti-estrogenic effects in breast cancer cells with potency similar to 4-hydroxy-tamoxifen publication-title: Cancer Chemother Pharmacol. doi: 10.1007/s00280-004-0926-7 – volume: 131 start-page: 455 year: 2012 end-page: 461 ident: CR46 article-title: Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-011-1425-2 – volume: 23 start-page: 9312 year: 2005 end-page: 9318 ident: CR17 article-title: Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes publication-title: J Clin Oncol. doi: 10.1200/JCO.2005.03.3266 – volume: 94 start-page: 185 issue: 2 year: 2014 end-page: 187 ident: CR64 article-title: CYP2D6 genotype and tamoxifen activity: understanding interstudy variability in methodological quality publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2013.66 – volume: 26 start-page: 319 issue: 3 year: 2015 end-page: 332 ident: CR57 article-title: Role of cytochrome P450 genes in breast cancer etiology and treatment: effects on estrogen biosynthesis, metabolism, and response to endocrine therapy publication-title: Cancer Causes Control. doi: 10.1007/s10552-014-0519-7 – volume: 80 start-page: 61 year: 2006 end-page: 74 ident: CR14 article-title: Quantitative effect of CYP2D6 genotype and inhibitors on tamoxifen metabolism: implication for optimization of breast cancer treatment publication-title: Clin Pharmacol Ther. doi: 10.1016/j.clpt.2006.03.013 – volume: 103 start-page: 489 year: 2011 end-page: 500 ident: CR22 article-title: CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djr010 – volume: 8 start-page: e70183 year: 2013 ident: CR16 article-title: Relationship between genotypes Sult1a2 and Cyp2d6 and tamoxifen metabolism in breast cancer patients publication-title: PLoS One. doi: 10.1371/journal.pone.0070183 – volume: 12 start-page: 1535 year: 2011 end-page: 1543 ident: CR25 article-title: SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen publication-title: Pharmacogenomics. doi: 10.2217/pgs.11.97 – volume: 217 start-page: 61 year: 2005 end-page: 72 ident: CR37 article-title: Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients publication-title: Cancer Lett. doi: 10.1016/j.canlet.2004.08.027 – volume: 89 start-page: 718 year: 2011 end-page: 725 ident: CR24 article-title: Tamoxifen metabolite concentrations, CYP2D6 genotype, and breast cancer outcomes publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2011.32 – volume: 73 start-page: 1181 year: 2014 end-page: 1188 ident: CR27 article-title: Impact of variable CYP genotypes on breast cancer relapse in patients undergoing adjuvant tamoxifen therapy publication-title: Cancer Chemother Pharmacol. doi: 10.1007/s00280-014-2453-5 – volume: 23 start-page: 619 year: 2005 end-page: 629 ident: CR5 article-title: American Society of Clinical Oncology technology assessment on the use of aromatase inhibitors as adjuvant therapy for postmenopausal women with hormone receptor-positive breast cancer: status report 2004 publication-title: J Clin Oncol. doi: 10.1200/JCO.2005.09.121 – volume: 378 start-page: 771 year: 2011 end-page: 784 ident: CR7 article-title: Relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials publication-title: Lancet. doi: 10.1016/S0140-6736(11)60993-8 – volume: 143 start-page: 447 year: 2014 end-page: 483 ident: CR66 article-title: Tamoxifen dose and serum concentrations of tamoxifen and six of its metabolites in routine clinical outpatient care publication-title: Breast Cancer Res. doi: 10.1007/s10549-013-2824-3 – volume: 89 start-page: 708 year: 2011 end-page: 717 ident: CR26 article-title: Activity levels of tamoxifen metabolites at the estrogen receptor and the impact of genetic polymorphisms of phase I and II enzymes on their concentration levels in plasma publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2011.27 – volume: 25 start-page: 5187 year: 2007 end-page: 5193 ident: CR33 article-title: Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes publication-title: J Clin Oncol. doi: 10.1200/JCO.2007.12.2705 – volume: 7 start-page: R284 year: 2005 end-page: R290 ident: CR38 article-title: Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients publication-title: Breast Cancer Res. doi: 10.1186/bcr993 – volume: 85 start-page: 151 year: 2004 end-page: 159 ident: CR10 article-title: Pharmacological characterization of 4-hydroxy- -desmethyl tamoxifen, a novel active metabolite of tamoxifen publication-title: Breast Cancer Res Treat. doi: 10.1023/B:BREA.0000025406.31193.e8 – volume: 310 start-page: 1062 year: 2004 end-page: 1075 ident: CR8 article-title: Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6 publication-title: J Pharmacol Exp Ther. doi: 10.1124/jpet.104.065607 – volume: 96 start-page: 138 year: 2014 end-page: 140 ident: CR55 article-title: CYP2D6 genotype and adjuvant tamoxifen publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2014.96 – volume: 26 start-page: 1007 year: 2011 end-page: 1013 ident: CR47 article-title: Association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment publication-title: J Korean Med Sci. doi: 10.3346/jkms.2011.26.8.1007 – volume: 95 start-page: 216 year: 2014 end-page: 227 ident: CR53 article-title: CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2013.186 – volume: 91 start-page: 249 year: 2005 end-page: 258 ident: CR28 article-title: Association of genetic variation in tamoxifen-metabolizing enzymes with overall survival and recurrence of disease in breast cancer patients publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-004-7751-x – volume: 78 start-page: 572 year: 2014 end-page: 586 ident: CR65 article-title: Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen publication-title: Br J Clin Pharmacol. doi: 10.1111/bcp.12388 – ident: CR3 – volume: 16 start-page: 4468 year: 2010 end-page: 4477 ident: CR63 article-title: CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-10-0478 – volume: 19 start-page: 1423 year: 2008 end-page: 1429 ident: CR40 article-title: Association between CYP2D6*10 genotype and survival of breast cancer patients receiving tamoxifen treatment publication-title: Ann Oncol. doi: 10.1093/annonc/mdn155 – volume: 29 start-page: 3232 year: 2011 end-page: 3239 ident: CR68 article-title: Genotype-guided tamoxifen dosing increases active metabolite exposure in women with reduced CYP2D6 metabolism: a multicenter study publication-title: J Clin Oncol. doi: 10.1200/JCO.2010.31.4427 – volume: 9 start-page: R7 year: 2007 ident: CR39 article-title: Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer publication-title: Breast Cancer Res. doi: 10.1186/bcr1640 – volume: 97 start-page: 30 year: 2005 end-page: 39 ident: CR19 article-title: CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/dji005 – volume: 50 start-page: 199 year: 1984 end-page: 205 ident: CR69 article-title: A comparison of two doses of tamoxifen (Novaldex) in postmenopausal women with advanced breast cancer: 10 mg bd versus 20 mg bd publication-title: Br J Cancer. doi: 10.1038/bjc.1984.163 – volume: 11 start-page: 597 year: 2011 end-page: 608 ident: CR11 article-title: The different roles of ER subtypes in cancer biology and therapy publication-title: Nat Rev Cancer. doi: 10.1038/nrc3093 – volume: 131 start-page: 137 year: 2012 end-page: 145 ident: CR67 article-title: Dose-adjustment study of tamoxifen based on CYP2D6 genotypes in Japanese breast cancer patients publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-011-1777-7 – volume: 99 start-page: 995 year: 2008 end-page: 999 ident: CR20 article-title: Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2008.00780.x – volume: 1 start-page: 84 year: 2014 end-page: 94 ident: CR32 article-title: Tamoxifen metabolism predicts drug concentrations and outcome in premenopausal patients with early breast cancer publication-title: Pharmacogenomics J. – ident: CR62 – volume: 381 start-page: 805 year: 2013 end-page: 816 ident: CR2 article-title: Long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years after diagnosis of oestrogen erceptor-positive breast cancer: ATLAS, a randomised trial publication-title: Lancet. doi: 10.1016/S0140-6736(12)61963-1 – volume: 19 start-page: 56 year: 2008 end-page: 61 ident: CR42 article-title: Effects of CYP2D6 and SULT1A1 genotypes including SULT1A1 gene copy number on tamoxifen metabolism publication-title: Ann Oncol. doi: 10.1093/annonc/mdm434 – volume: 6 start-page: 93 year: 2013 end-page: 98 ident: CR35 article-title: Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen publication-title: Pharmgenomics Pers Med. – volume: 6 start-page: 93 year: 2013 ident: 273_CR35 publication-title: Pharmgenomics Pers Med. – volume: 227 start-page: 115 year: 2005 ident: 273_CR58 publication-title: Cancer Lett. doi: 10.1016/j.canlet.2004.10.007 – ident: 273_CR3 doi: 10.1200/jco.2013.31.18_suppl.5 – volume: 78 start-page: 572 year: 2014 ident: 273_CR65 publication-title: Br J Clin Pharmacol. doi: 10.1111/bcp.12388 – volume: 12 start-page: 1101 year: 2011 ident: 273_CR4 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(11)70270-4 – volume: 217 start-page: 61 year: 2005 ident: 273_CR37 publication-title: Cancer Lett. doi: 10.1016/j.canlet.2004.08.027 – volume: 50 start-page: 199 year: 1984 ident: 273_CR69 publication-title: Br J Cancer. doi: 10.1038/bjc.1984.163 – volume: 55 start-page: 471 year: 2005 ident: 273_CR9 publication-title: Cancer Chemother Pharmacol. doi: 10.1007/s00280-004-0926-7 – volume: 19 start-page: 1423 year: 2008 ident: 273_CR40 publication-title: Ann Oncol. doi: 10.1093/annonc/mdn155 – volume: 19 start-page: 56 year: 2008 ident: 273_CR42 publication-title: Ann Oncol. doi: 10.1093/annonc/mdm434 – volume: 19 start-page: 500 year: 2013 ident: 273_CR18 publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-12-2153 – volume: 23 start-page: 619 year: 2005 ident: 273_CR5 publication-title: J Clin Oncol. doi: 10.1200/JCO.2005.09.121 – volume: 25 start-page: 5187 year: 2007 ident: 273_CR33 publication-title: J Clin Oncol. doi: 10.1200/JCO.2007.12.2705 – volume: 94 start-page: 185 issue: 2 year: 2014 ident: 273_CR64 publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2013.66 – volume: 302 start-page: 1429 year: 2009 ident: 273_CR34 publication-title: JAMA. doi: 10.1001/jama.2009.1420 – volume: 80 start-page: 61 year: 2006 ident: 273_CR14 publication-title: Clin Pharmacol Ther. doi: 10.1016/j.clpt.2006.03.013 – volume: 6 start-page: 37 year: 2013 ident: 273_CR15 publication-title: Pharmgenomics Pers Med. – volume: 104 start-page: 441 year: 2012 ident: 273_CR31 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djs125 – volume: 29 start-page: 3232 year: 2011 ident: 273_CR68 publication-title: J Clin Oncol. doi: 10.1200/JCO.2010.31.4427 – volume: 365 start-page: 1687 year: 2005 ident: 273_CR1 publication-title: Lancet. doi: 10.1016/S0140-6736(05)66544-0 – volume: 10 start-page: 313 year: 2010 ident: 273_CR59 publication-title: BMC Cancer. doi: 10.1186/1471-2407-10-313 – volume: 9 start-page: 529 year: 2012 ident: 273_CR49 publication-title: Nat Rev Clin Oncol. doi: 10.1038/nrclinonc.2012.121 – volume: 73 start-page: 1181 year: 2014 ident: 273_CR27 publication-title: Cancer Chemother Pharmacol. doi: 10.1007/s00280-014-2453-5 – volume: 26 start-page: 1007 year: 2011 ident: 273_CR47 publication-title: J Korean Med Sci. doi: 10.3346/jkms.2011.26.8.1007 – volume: 71 start-page: 737 year: 2011 ident: 273_CR23 publication-title: Br J Clin Pharmacol. doi: 10.1111/j.1365-2125.2011.03905.x – volume: 25 start-page: 2127 year: 2007 ident: 273_CR51 publication-title: J Clin Oncol. doi: 10.1200/JCO.2006.10.3523 – volume: 23 start-page: 9312 year: 2005 ident: 273_CR17 publication-title: J Clin Oncol. doi: 10.1200/JCO.2005.03.3266 – volume: 115 start-page: 952 year: 2009 ident: 273_CR29 publication-title: Cancer. doi: 10.1002/cncr.24111 – volume: 139 start-page: 649 year: 2013 ident: 273_CR13 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-013-2568-0 – volume: 133 start-page: 793 year: 2012 ident: 273_CR60 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-012-2000-1 – ident: 273_CR62 doi: 10.1093/jnci/dju401 – volume: 131 start-page: 137 year: 2012 ident: 273_CR67 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-011-1777-7 – volume: 139 start-page: 95 year: 2013 ident: 273_CR36 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-013-2511-4 – volume: 11 start-page: 597 year: 2011 ident: 273_CR11 publication-title: Nat Rev Cancer. doi: 10.1038/nrc3093 – volume: 378 start-page: 771 year: 2011 ident: 273_CR7 publication-title: Lancet. doi: 10.1016/S0140-6736(11)60993-8 – volume: 97 start-page: 30 year: 2005 ident: 273_CR19 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/dji005 – volume: 89 start-page: 718 year: 2011 ident: 273_CR24 publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2011.32 – volume: 131 start-page: 455 year: 2012 ident: 273_CR46 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-011-1425-2 – volume: 734 start-page: 310 year: 1994 ident: 273_CR70 publication-title: Ann NY Acad Sci. doi: 10.1111/j.1749-6632.1994.tb21761.x – ident: 273_CR12 – volume: 26 start-page: 319 issue: 3 year: 2015 ident: 273_CR57 publication-title: Cancer Causes Control. doi: 10.1007/s10552-014-0519-7 – volume: 1 start-page: 84 year: 2014 ident: 273_CR32 publication-title: Pharmacogenomics J. – volume: 96 start-page: 138 year: 2014 ident: 273_CR55 publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2014.96 – volume: 8 start-page: e70183 year: 2013 ident: 273_CR16 publication-title: PLoS One. doi: 10.1371/journal.pone.0070183 – volume: 381 start-page: 805 year: 2013 ident: 273_CR2 publication-title: Lancet. doi: 10.1016/S0140-6736(12)61963-1 – volume: 103 start-page: 489 year: 2011 ident: 273_CR22 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djr010 – volume: 85 start-page: 151 year: 2004 ident: 273_CR10 publication-title: Breast Cancer Res Treat. doi: 10.1023/B:BREA.0000025406.31193.e8 – volume: 10 start-page: 932 year: 2013 ident: 273_CR41 publication-title: Int J Med Sci. doi: 10.7150/ijms.5708 – volume: 91 start-page: 249 year: 2005 ident: 273_CR28 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-004-7751-x – volume: 9 start-page: R7 year: 2007 ident: 273_CR39 publication-title: Breast Cancer Res. doi: 10.1186/bcr1640 – volume: 12 start-page: R64 issue: 4 year: 2010 ident: 273_CR45 publication-title: Breast Cancer Res. doi: 10.1186/bcr2629 – volume: 10 start-page: 825 year: 2009 ident: 273_CR56 publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(09)70030-0 – volume: 12 start-page: 1535 year: 2011 ident: 273_CR25 publication-title: Pharmacogenomics. doi: 10.2217/pgs.11.97 – volume: 90 start-page: 605 year: 2011 ident: 273_CR48 publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2011.153 – volume: 310 start-page: 1062 year: 2004 ident: 273_CR8 publication-title: J Pharmacol Exp Ther. doi: 10.1124/jpet.104.065607 – volume: 7 start-page: R284 year: 2005 ident: 273_CR38 publication-title: Breast Cancer Res. doi: 10.1186/bcr993 – volume: 139 start-page: 923 year: 2013 ident: 273_CR61 publication-title: Breast Cancer Res Treat. doi: 10.1007/s10549-013-2585-z – volume: 89 start-page: 708 year: 2011 ident: 273_CR26 publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2011.27 – volume: 104 start-page: 452 year: 2012 ident: 273_CR30 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djs126 – ident: 273_CR50 – volume: 39 start-page: 651 year: 2009 ident: 273_CR43 publication-title: Jpn J Clin Oncol. doi: 10.1093/jjco/hyp076 – volume: 348 start-page: 2431 year: 2003 ident: 273_CR6 publication-title: N Engl J Med. doi: 10.1056/NEJMra023246 – volume: 26 start-page: 2535 year: 2010 ident: 273_CR44 publication-title: Curr Med Res Opin. doi: 10.1185/03007995.2010.518304 – volume: 143 start-page: 447 year: 2014 ident: 273_CR66 publication-title: Breast Cancer Res. doi: 10.1007/s10549-013-2824-3 – volume: 16 start-page: 4468 year: 2010 ident: 273_CR63 publication-title: Clin Cancer Res. doi: 10.1158/1078-0432.CCR-10-0478 – volume: 95 start-page: 216 year: 2014 ident: 273_CR53 publication-title: Clin Pharmacol Ther. doi: 10.1038/clpt.2013.186 – volume: 54 start-page: 157 year: 2002 ident: 273_CR52 publication-title: Br J Clin Pharmacol. doi: 10.1046/j.1365-2125.2002.01614.x – volume: 105 start-page: 1267 year: 2013 ident: 273_CR54 publication-title: J Natl Cancer Inst. doi: 10.1093/jnci/djt221 – volume: 99 start-page: 995 year: 2008 ident: 273_CR20 publication-title: Cancer Sci. doi: 10.1111/j.1349-7006.2008.00780.x – volume: 28 start-page: 1287 year: 2010 ident: 273_CR21 publication-title: J Clin Oncol. doi: 10.1200/JCO.2009.25.7246 – reference: 17513820 - J Clin Oncol. 2007 May 20;25(15):2127-32 – reference: 21860550 - J Korean Med Sci. 2011 Aug;26(8):1007-13 – reference: 23872831 - Clin Pharmacol Ther. 2013 Aug;94(2):185-7 – reference: 21779010 - Nat Rev Cancer. 2011 Aug;11(8):597-608 – reference: 23213055 - Clin Cancer Res. 2013 Jan 15;19(2):500-7 – reference: 23736997 - Breast Cancer Res Treat. 2013 Jun;139(3):649-55 – reference: 24682508 - Cancer Chemother Pharmacol. 2014 Jun;73(6):1181-8 – reference: 21451508 - Clin Pharmacol Ther. 2011 May;89(5):708-17 – reference: 22395643 - J Natl Cancer Inst. 2012 Mar 21;104(6):452-60 – reference: 16112414 - Cancer Lett. 2005 Sep 28;227(2):115-24 – reference: 12207635 - Br J Clin Pharmacol. 2002 Aug;54(2):157-67 – reference: 24697814 - Br J Clin Pharmacol. 2014 Sep;78(3):572-86 – reference: 15987423 - Breast Cancer Res. 2005;7(3):R284-90 – reference: 23219286 - Lancet. 2013 Mar 9;381(9869):805-16 – reference: 21430657 - Clin Pharmacol Ther. 2011 May;89(5):718-25 – reference: 23922954 - PLoS One. 2013;8(7):e70183 – reference: 21900890 - Clin Pharmacol Ther. 2011 Oct;90(4):605-11 – reference: 22395644 - J Natl Cancer Inst. 2012 Mar 21;104(6):441-51 – reference: 15111773 - Breast Cancer Res Treat. 2004 May;85(2):151-9 – reference: 18407954 - Ann Oncol. 2008 Aug;19(8):1423-9 – reference: 6380554 - Br J Cancer. 1984 Aug;50(2):199-205 – reference: 24019753 - Pharmgenomics Pers Med. 2013 Aug 26;6:93-8 – reference: 24060820 - Clin Pharmacol Ther. 2014 Feb;95(2):216-27 – reference: 21802721 - Lancet. 2011 Aug 27;378(9793):771-84 – reference: 19809024 - JAMA. 2009 Oct 7;302(13):1429-36 – reference: 18294285 - Cancer Sci. 2008 May;99(5):995-9 – reference: 18024866 - J Clin Oncol. 2007 Nov 20;25(33):5187-93 – reference: 12802030 - N Engl J Med. 2003 Jun 12;348(24):2431-42 – reference: 20565970 - BMC Cancer. 2010;10:313 – reference: 7978932 - Ann N Y Acad Sci. 1994 Sep 30;734:310-21 – reference: 21480951 - Br J Clin Pharmacol. 2011 May;71(5):737-50 – reference: 23580071 - Breast Cancer Res Treat. 2013 May;139(1):95-105 – reference: 21768473 - J Clin Oncol. 2011 Aug 20;29(24):3232-9 – reference: 19156902 - Cancer. 2009 Mar 1;115(5):952-61 – reference: 15894097 - Lancet. 2005 May 14-20;365(9472):1687-717 – reference: 15596297 - Cancer Lett. 2005 Jan 10;217(1):61-72 – reference: 15685451 - Cancer Chemother Pharmacol. 2005 May;55(5):471-8 – reference: 21437611 - Breast Cancer Res Treat. 2012 Jan;131(2):455-61 – reference: 19596663 - Jpn J Clin Oncol. 2009 Oct;39(10):651-6 – reference: 20731819 - Breast Cancer Res. 2010;12(4):R64 – reference: 15545664 - J Clin Oncol. 2005 Jan 20;23(3):619-29 – reference: 23760858 - Breast Cancer Res Treat. 2013 Jun;139(3):923-9 – reference: 21961651 - Pharmacogenomics. 2011 Nov;12(11):1535-43 – reference: 25091503 - Pharmacogenomics J. 2015 Feb;15(1):84-94 – reference: 15632378 - J Natl Cancer Inst. 2005 Jan 5;97(1):30-9 – reference: 24390246 - Breast Cancer Res Treat. 2014 Feb;143(3):477-83 – reference: 20849243 - Curr Med Res Opin. 2010 Nov;26(11):2535-42 – reference: 23776391 - Pharmgenomics Pers Med. 2013 May 24;6:37-48 – reference: 17244352 - Breast Cancer Res. 2007;9(1):R7 – reference: 20124171 - J Clin Oncol. 2010 Mar 10;28(8):1287-93 – reference: 21947681 - Breast Cancer Res Treat. 2012 Jan;131(1):137-45 – reference: 22825374 - Nat Rev Clin Oncol. 2012 Sep;9(9):529-41 – reference: 25554091 - Cancer Causes Control. 2015 Mar;26(3):319-32 – reference: 15159443 - J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75 – reference: 16815318 - Clin Pharmacol Ther. 2006 Jul;80(1):61-74 – reference: 16361630 - J Clin Oncol. 2005 Dec 20;23(36):9312-8 – reference: 23958737 - J Natl Cancer Inst. 2013 Sep 4;105(17):1267-9 – reference: 20515869 - Clin Cancer Res. 2010 Sep 1;16(17):4468-77 – reference: 21325141 - J Natl Cancer Inst. 2011 Mar 16;103(6):489-500 – reference: 22388692 - Breast Cancer Res Treat. 2012 Jun;133(2):793-8 – reference: 25056391 - Clin Pharmacol Ther. 2014 Aug;96(2):138-40 – reference: 22018631 - Lancet Oncol. 2011 Nov;12(12):1101-8 – reference: 15952058 - Breast Cancer Res Treat. 2005 Jun;91(3):249-58 – reference: 19647203 - Lancet Oncol. 2009 Aug;10(8):825-33 – reference: 25490892 - J Natl Cancer Inst. 2015 Feb;107(2). pii: dju401. doi: 10.1093/jnci/dju401 – reference: 17947222 - Ann Oncol. 2008 Jan;19(1):56-61 – reference: 23781139 - Int J Med Sci. 2013;10(7):932-7 |
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| SubjectTerms | Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Estrogen Antagonists - pharmacokinetics Estrogen Antagonists - pharmacology Female Humans Internal Medicine Medicine Medicine & Public Health Pharmacology/Toxicology Pharmacotherapy Precision Medicine - methods Review Review Article Tamoxifen - pharmacokinetics Tamoxifen - pharmacology |
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