FABP4 as a key determinant of metastatic potential of ovarian cancer

The standard treatment for high-grade serous ovarian cancer is primary debulking surgery followed by chemotherapy. The extent of metastasis and invasive potential of lesions can influence the outcome of these primary surgeries. Here, we explored the underlying mechanisms that could increase metastat...

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Bibliographic Details
Published in:	Nature communications Vol. 9; no. 1; pp. 2923 - 14
Main Authors:	Gharpure, Kshipra M., Pradeep, Sunila, Sans, Marta, Rupaimoole, Rajesha, Ivan, Cristina, Wu, Sherry Y., Bayraktar, Emine, Nagaraja, Archana S., Mangala, Lingegowda S., Zhang, Xinna, Haemmerle, Monika, Hu, Wei, Rodriguez-Aguayo, Cristian, McGuire, Michael, Mak, Celia Sze Ling, Chen, Xiuhui, Tran, Michelle A., Villar-Prados, Alejandro, Pena, Guillermo Armaiz, Kondetimmanahalli, Ragini, Nini, Ryan, Koppula, Pranavi, Ram, Prahlad, Liu, Jinsong, Lopez-Berestein, Gabriel, Baggerly, Keith, S. Eberlin, Livia, Sood, Anil K.
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 26.07.2018 Nature Publishing Group Nature Portfolio
Subjects:	13/106 13/51 38/109 38/32 38/77 631/67/1059 631/67/1517/1709 631/67/322 Animal models Animals Cancer Cell Line, Tumor Chemotherapy Fatty acid-binding protein Fatty Acid-Binding Proteins - genetics Fatty Acid-Binding Proteins - metabolism Female Gene Expression Regulation, Neoplastic - genetics Gene Expression Regulation, Neoplastic - physiology Humanities and Social Sciences Humans Hypoxia Invasiveness Lesions Metabolic pathways Metabolites Metastases Metastasis Mice Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism multidisciplinary Neoplasm Invasiveness - genetics Neoplasm Invasiveness - pathology Ovarian cancer Ovarian Neoplasms - genetics Ovarian Neoplasms - metabolism Ovarian Neoplasms - pathology Proteins Science Science (multidisciplinary) siRNA Surgery
ISSN:	2041-1723, 2041-1723
Online Access:	Get full text
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