Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340 and miRNA624
Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself....
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| Vydané v: | PloS one Ročník 6; číslo 10; s. e25946 |
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| Hlavní autori: | , , , , , , , , , , , , , , , |
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| Jazyk: | English |
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United States
Public Library of Science
13.10.2011
Public Library of Science (PLoS) |
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls.
In this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts.
Two miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. |
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| AbstractList | Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls. In this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts. Two miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. Background Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls. Methodology/Principal Findings In this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts. Conclusion/Significance Two miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls.BACKGROUNDCoronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls.In this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts.METHODOLOGY/PRINCIPAL FINDINGSIn this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts.Two miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study.CONCLUSION/SIGNIFICANCETwo miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls. In this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts. Two miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. Background Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls. Methodology/Principal Findings In this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts. Conclusion/Significance Two miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. BackgroundCoronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not only in the process of acute thrombosis during plaque rupture, but also in the formation of atherosclerosis itself. MicroRNAs are endogenous small non-coding RNAs that control gene expression and are expressed in a tissue and disease-specific manner. Therefore they have been proposed to be useful biomarkers. It remains unknown whether differences in miRNA expression levels in platelets can be found between patients with premature CAD and healthy controls.Methodology/principal findingsIn this case-control study we measured relative expression levels of platelet miRNAs using microarrays from 12 patients with premature CAD and 12 age- and sex-matched healthy controls. Six platelet microRNAs were significantly upregulated (miR340*, miR451, miR454*, miR545:9.1. miR615-5p and miR624*) and one miRNA (miR1280) was significantly downregulated in patients with CAD as compared to healthy controls. To validate these results, we measured the expression levels of these candidate miRNAs by qRT-PCR in platelets of individuals from two independent cohorts; validation cohort I consisted of 40 patients with premature CAD and 40 healthy controls and validation cohort II consisted of 27 patients with artery disease and 40 healthy relatives. MiR340* and miR624* were confirmed to be upregulated in patients with CAD as compared to healthy controls in both validation cohorts.Conclusion/significanceTwo miRNAs in platelets are significantly upregulated in patients with CAD as compared to healthy controls. Whether the two identified miRNAs can be used as biomarkers and whether they are cause or consequence of the disease remains to be elucidated in a larger prospective study. |
| Audience | Academic |
| Author | Bakker, Annemieke Pinto-Sietsma, Sara-Joan de Ronde, Maurice W. J. Moerland, Perry D. Mulders, Ties A. Creemers, Esther E. Meijers, Joost C. M. Trip, Mieke D. Tijsen, Anke J. Battjes, Suzanne Sondermeijer, Brigitte M. Halliani, Amalia Marquart, Arnoud A. Maiwald, Steffi Kok, Maayke G. M. Sivapalaratnam, Suthesh |
| AuthorAffiliation | 3 Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 4 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands Leiden University Medical Center, The Netherlands 1 Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands 2 Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands |
| AuthorAffiliation_xml | – name: 2 Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands – name: Leiden University Medical Center, The Netherlands – name: 3 Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands – name: 1 Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands – name: 4 Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands |
| Author_xml | – sequence: 1 givenname: Brigitte M. surname: Sondermeijer fullname: Sondermeijer, Brigitte M. – sequence: 2 givenname: Annemieke surname: Bakker fullname: Bakker, Annemieke – sequence: 3 givenname: Amalia surname: Halliani fullname: Halliani, Amalia – sequence: 4 givenname: Maurice W. J. surname: de Ronde fullname: de Ronde, Maurice W. J. – sequence: 5 givenname: Arnoud A. surname: Marquart fullname: Marquart, Arnoud A. – sequence: 6 givenname: Anke J. surname: Tijsen fullname: Tijsen, Anke J. – sequence: 7 givenname: Ties A. surname: Mulders fullname: Mulders, Ties A. – sequence: 8 givenname: Maayke G. M. surname: Kok fullname: Kok, Maayke G. M. – sequence: 9 givenname: Suzanne surname: Battjes fullname: Battjes, Suzanne – sequence: 10 givenname: Steffi surname: Maiwald fullname: Maiwald, Steffi – sequence: 11 givenname: Suthesh surname: Sivapalaratnam fullname: Sivapalaratnam, Suthesh – sequence: 12 givenname: Mieke D. surname: Trip fullname: Trip, Mieke D. – sequence: 13 givenname: Perry D. surname: Moerland fullname: Moerland, Perry D. – sequence: 14 givenname: Joost C. M. surname: Meijers fullname: Meijers, Joost C. M. – sequence: 15 givenname: Esther E. surname: Creemers fullname: Creemers, Esther E. – sequence: 16 givenname: Sara-Joan surname: Pinto-Sietsma fullname: Pinto-Sietsma, Sara-Joan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/22022480$$D View this record in MEDLINE/PubMed |
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| Copyright | COPYRIGHT 2011 Public Library of Science 2011 Sondermeijer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Sondermeijer et al. 2011 |
| Copyright_xml | – notice: COPYRIGHT 2011 Public Library of Science – notice: 2011 Sondermeijer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Sondermeijer et al. 2011 |
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| DOI | 10.1371/journal.pone.0025946 |
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| References | 21785714 - Cardiol Res Pract. 2011;2011:532915 15992651 - J Am Coll Cardiol. 2005 Jul 5;46(1):158-65 20159880 - Eur Heart J. 2010 Mar;31(6):659-66 18773077 - PLoS One. 2008;3(9):e3148 20886220 - Basic Res Cardiol. 2011 Jan;106(1):13-23 14657504 - Science. 2004 Jan 2;303(5654):83-6 18508790 - Haematologica. 2008 Jul;93(7):1009-16 18573170 - Eur J Haematol. 2008 Oct;81(4):304-10 19668211 - Nat Struct Mol Biol. 2009 Sep;16(9):961-6 15965474 - Nat Genet. 2005 Jul;37(7):766-70 20413612 - Genes Dev. 2010 May 15;24(10):992-1009 20029200 - Cardiology. 2010;115(3):163-9 21411089 - Atherosclerosis. 2011 Jun;216(2):452-7 18077812 - N Engl J Med. 2007 Dec 13;357(24):2482-94 20395621 - Clin Chem. 2010 Jul;56(7):1183-5 19002258 - PLoS One. 2008;3(11):e3694 20595655 - Circ Res. 2010 Sep 3;107(5):677-84 11591627 - Circulation. 2001 Oct 9;104(15):1863-7 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8 17060945 - Nat Rev Cancer. 2006 Nov;6(11):857-66 17786230 - J Clin Invest. 2007 Sep;117(9):2369-76 20921333 - Circ Cardiovasc Genet. 2010 Dec;3(6):499-506 15944708 - Nature. 2005 Jun 9;435(7043):834-8 21796641 - Biopharm Drug Dispos. 2011 Sep;32(6):355-67 20218970 - Clin Sci (Lond). 2010 Jul;119(2):87-95 12928466 - JAMA. 2003 Aug 20;290(7):898-904 16111679 - FEBS Lett. 2005 Oct 31;579(26):5911-22 20065196 - Arch Intern Med. 2010 Jan 11;170(1):27-40 18303086 - Physiol Genomics. 2008 Apr 22;33(2):139-47 18713256 - Clin Genet. 2008 Oct;74(4):296-306 11574787 - Curr Opin Cardiol. 2001 Jul;16(4):251-60 19896465 - Biochem Biophys Res Commun. 2010 Jan 1;391(1):73-7 20185794 - Circ Res. 2010 Apr 2;106(6):1035-9 18523662 - PLoS One. 2008;3(6):e2360 19696117 - Clin Chem. 2009 Nov;55(11):1944-9 12928465 - JAMA. 2003 Aug 20;290(7):891-7 |
| References_xml | – reference: 15992651 - J Am Coll Cardiol. 2005 Jul 5;46(1):158-65 – reference: 12928466 - JAMA. 2003 Aug 20;290(7):898-904 – reference: 18573170 - Eur J Haematol. 2008 Oct;81(4):304-10 – reference: 21785714 - Cardiol Res Pract. 2011;2011:532915 – reference: 16111679 - FEBS Lett. 2005 Oct 31;579(26):5911-22 – reference: 17786230 - J Clin Invest. 2007 Sep;117(9):2369-76 – reference: 20218970 - Clin Sci (Lond). 2010 Jul;119(2):87-95 – reference: 11591627 - Circulation. 2001 Oct 9;104(15):1863-7 – reference: 15965474 - Nat Genet. 2005 Jul;37(7):766-70 – reference: 20029200 - Cardiology. 2010;115(3):163-9 – reference: 21796641 - Biopharm Drug Dispos. 2011 Sep;32(6):355-67 – reference: 12928465 - JAMA. 2003 Aug 20;290(7):891-7 – reference: 20886220 - Basic Res Cardiol. 2011 Jan;106(1):13-23 – reference: 11574787 - Curr Opin Cardiol. 2001 Jul;16(4):251-60 – reference: 20921333 - Circ Cardiovasc Genet. 2010 Dec;3(6):499-506 – reference: 17060945 - Nat Rev Cancer. 2006 Nov;6(11):857-66 – reference: 18713256 - Clin Genet. 2008 Oct;74(4):296-306 – reference: 18523662 - PLoS One. 2008;3(6):e2360 – reference: 18663219 - Proc Natl Acad Sci U S A. 2008 Jul 29;105(30):10513-8 – reference: 18077812 - N Engl J Med. 2007 Dec 13;357(24):2482-94 – reference: 18773077 - PLoS One. 2008;3(9):e3148 – reference: 15944708 - Nature. 2005 Jun 9;435(7043):834-8 – reference: 18303086 - Physiol Genomics. 2008 Apr 22;33(2):139-47 – reference: 19896465 - Biochem Biophys Res Commun. 2010 Jan 1;391(1):73-7 – reference: 20413612 - Genes Dev. 2010 May 15;24(10):992-1009 – reference: 19002258 - PLoS One. 2008;3(11):e3694 – reference: 21411089 - Atherosclerosis. 2011 Jun;216(2):452-7 – reference: 19668211 - Nat Struct Mol Biol. 2009 Sep;16(9):961-6 – reference: 19696117 - Clin Chem. 2009 Nov;55(11):1944-9 – reference: 18508790 - Haematologica. 2008 Jul;93(7):1009-16 – reference: 20395621 - Clin Chem. 2010 Jul;56(7):1183-5 – reference: 20185794 - Circ Res. 2010 Apr 2;106(6):1035-9 – reference: 20595655 - Circ Res. 2010 Sep 3;107(5):677-84 – reference: 20159880 - Eur Heart J. 2010 Mar;31(6):659-66 – reference: 14657504 - Science. 2004 Jan 2;303(5654):83-6 – reference: 20065196 - Arch Intern Med. 2010 Jan 11;170(1):27-40 |
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| Snippet | Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies.... Background Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic... BackgroundCoronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic... Background Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic... |
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| SubjectTerms | Adult Arteriosclerosis Atherosclerosis Bioinformatics Biology Biomarkers Blood platelets Blood Platelets - metabolism Cardiac patients Cardiology Cardiovascular disease Care and treatment Case-Control Studies Cohort Studies Coronary artery Coronary artery disease Coronary Artery Disease - genetics Coronary heart disease Coronary vessels Data collection Diagnostic systems Disease control Disease prevention DNA microarrays Epidemiology Family medical history Gene expression Gene Expression Profiling Genetic Association Studies Health aspects Heart attacks Heart diseases Heart failure Humans Male Medical research Medicine MicroRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Middle Aged miRNA Morbidity Mortality Patients Platelets Reproducibility of Results Ribonucleic acid Risk assessment RNA Teaching hospitals Thromboembolism Thrombosis Up-Regulation - genetics |
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| Title | Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340 and miRNA624 |
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