Small-RNA-mediated transgenerational silencing of histone genes impairs fertility in piRNA mutants

PIWI-interacting RNAs (piRNAs) promote fertility in many animals. However, whether this is due to their conserved role in repressing repetitive elements (REs) remains unclear. Here, we show that the progressive loss of fertility in Caenorhabditis elegans lacking piRNAs is not caused by derepression...

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Veröffentlicht in:	Nature cell biology Jg. 22; H. 2; S. 235 - 245
Hauptverfasser:	Barucci, Giorgia, Cornes, Eric, Singh, Meetali, Li, Blaise, Ugolini, Martino, Samolygo, Aleksei, Didier, Celine, Dingli, Florent, Loew, Damarys, Quarato, Piergiuseppe, Cecere, Germano
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Nature Publishing Group 01.02.2020
Schlagworte:	Animals Animals, Genetically Modified Antisense RNA Argonaute Proteins - deficiency Argonaute Proteins - genetics Argonaute Proteins - metabolism Biological Evolution Caenorhabditis elegans Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism CRISPR-Cas Systems Derepression Epigenetics Fertility Fertility - genetics Gene Editing Gene expression Gene Silencing Genes Heredity Histones Histones - genetics Histones - metabolism Inheritance Patterns Mutation Nematodes Repetitive Sequences, Nucleic Acid RNA, Antisense - genetics RNA, Antisense - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Small Interfering - genetics RNA, Small Interfering - metabolism RNA-mediated interference Worms
ISSN:	1465-7392, 1476-4679, 1476-4679
Online-Zugang:	Volltext
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