Associated Symptoms in the Ten Days Before Diagnosis of Kawasaki Disease

To describe common associated symptoms within the 10 days before diagnosis in subjects enrolled in the Pediatric Heart Network's trial of steroid therapy in Kawasaki disease (KD). Patients with acute KD were enrolled between days 4 and 10 of illness at 8 centers between 2002 and 2004. We define...

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Bibliographic Details
Published in:The Journal of pediatrics Vol. 154; no. 4; pp. 592 - 595.e2
Main Authors: Baker, Annette L., Lu, Minmin, Minich, L. LuAnn, Atz, Andrew M., Klein, Gloria L., Korsin, Rosalind, Lambert, Linda, Li, Jennifer S., Mason, Wilbert, Radojewski, Elizabeth, Vetter, Victoria L., Newburger, Jane W.
Format: Journal Article
Language:English
Published: Maryland Heights, MO Mosby, Inc 01.04.2009
Elsevier
Subjects:
Abdominal Pain - epidemiology
Appetite
Arthralgia - epidemiology
Biological and medical sciences
Cough - epidemiology
Diarrhea - epidemiology
Early Diagnosis
General aspects
Humans
Infant
Irritable Mood
Medical sciences
Mucocutaneous Lymph Node Syndrome - diagnosis
Mucocutaneous Lymph Node Syndrome - epidemiology
Muscle Weakness - epidemiology
North America - epidemiology
Pediatrics
Prevalence
Prospective Studies
Rhinitis - epidemiology
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Vomiting - epidemiology
North America
IVIG
KD
IVMP
ESR
Kawasaki disease
Intravenous immunoglobulin
Erythrocyte sedimentation rate
Intravenous methylprednisolone
Vascular disease
Kawasaki syndrome
Immunopathology
Pediatrics
Symptomatology
Vasculitis
Systemic disease
Autoimmune disease
Cardiovascular disease
Diagnosis
ISSN:0022-3476, 1097-6833, 1097-6833
Online Access:Get full text
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Summary:To describe common associated symptoms within the 10 days before diagnosis in subjects enrolled in the Pediatric Heart Network's trial of steroid therapy in Kawasaki disease (KD). Patients with acute KD were enrolled between days 4 and 10 of illness at 8 centers between 2002 and 2004. We defined common associated symptoms as those occurring in ≥10% of patients. Principal clinical criteria for KD were not included in this analysis. Among 198 patients, irritability was reported in 98 (50%), vomiting in 88 (44%), decreased food/fluid intake in 73 (37%), cough in 55 (28%), diarrhea in 52 (26%), rhinorrhea in 37 (19%), weakness in 37 (19%), abdominal pain in 35 (18%), and joint pain (arthralgia or arthritis) in 29 (15%). One or more gastrointestinal symptom (vomiting, diarrhea, or abdominal pain) was present in 120 patients (61%) and 69 patients (35%) had ≥ 1 respiratory symptom (rhinorrhea or cough). Nonspecific symptoms occur commonly in children with KD. To reduce delays in diagnosis, clinicians should be educated that such symptoms may comprise a significant component in the chief complaint.
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ISSN:0022-3476
1097-6833
1097-6833
DOI:10.1016/j.jpeds.2008.10.006