Complex genetic signatures in immune cells underlie autoimmunity and inform therapy

We report on the influence of ~22 million variants on 731 immune cell traits in a cohort of 3,757 Sardinians. We detected 122 significant ( P < 1.28 × 10 −11 ) independent association signals for 459 cell traits at 70 loci (53 of them novel) identifying several molecules and mechanisms involved...

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Bibliographic Details
Published in:	Nature genetics Vol. 52; no. 10; pp. 1036 - 1045
Main Authors:	Orrù, Valeria, Steri, Maristella, Sidore, Carlo, Marongiu, Michele, Serra, Valentina, Olla, Stefania, Sole, Gabriella, Lai, Sandra, Dei, Mariano, Mulas, Antonella, Virdis, Francesca, Piras, Maria Grazia, Lobina, Monia, Marongiu, Mara, Pitzalis, Maristella, Deidda, Francesca, Loizedda, Annalisa, Onano, Stefano, Zoledziewska, Magdalena, Sawcer, Stephen, Devoto, Marcella, Gorospe, Myriam, Abecasis, Gonçalo R., Floris, Matteo, Pala, Mauro, Schlessinger, David, Fiorillo, Edoardo, Cucca, Francesco
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.10.2020 Nature Publishing Group
Subjects:	631/208 631/250 692/699/249/1313 Adaptive immunity Agriculture Analysis Animal Genetics and Genomics Antigens Autoimmune diseases Autoimmune Diseases - drug therapy Autoimmune Diseases - epidemiology Autoimmune Diseases - genetics Autoimmune Diseases - pathology Autoimmunity Autoimmunity - genetics B cells Biomedical and Life Sciences Biomedicine Cancer Research Disease Drug development Flow cytometry Gene Function Genetic Predisposition to Disease Genome-Wide Association Study Genomes Genomics Health risks Human Genetics Humans Immune system Italy - epidemiology Loci Lymphocytes Pathogenesis Phenotype Phenotypes Polymorphism, Single Nucleotide - genetics Population Therapeutic targets Italy
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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