The Cytokine GM-CSF Drives the Inflammatory Signature of CCR2+ Monocytes and Licenses Autoimmunity

Granulocyte-macrophage colony-stimulating factor (GM-CSF) has emerged as a crucial cytokine produced by auto-reactive T helper (Th) cells that initiate tissue inflammation. Multiple cell types can sense GM-CSF, but the identity of the pathogenic GM-CSF-responsive cells is unclear. By using condition...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Jg. 43; H. 3; S. 502
Hauptverfasser:	Croxford, Andrew L, Lanzinger, Margit, Hartmann, Felix J, Schreiner, Bettina, Mair, Florian, Pelczar, Pawel, Clausen, Björn E, Jung, Steffen, Greter, Melanie, Becher, Burkhard
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 15.09.2015
Schlagworte:	Animals Antigens, Ly - genetics Antigens, Ly - immunology Antigens, Ly - metabolism Autoimmunity - genetics Autoimmunity - immunology Cytokine Receptor Common beta Subunit - genetics Cytokine Receptor Common beta Subunit - immunology Cytokine Receptor Common beta Subunit - metabolism Dendritic Cells - drug effects Dendritic Cells - immunology Dendritic Cells - metabolism Encephalomyelitis, Autoimmune, Experimental Flow Cytometry Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - metabolism Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology Humans Inflammation - genetics Inflammation - immunology Inflammation - metabolism Interleukin-1beta - genetics Interleukin-1beta - immunology Interleukin-1beta - metabolism Mice, Knockout Mice, Transgenic Monocytes - drug effects Monocytes - immunology Monocytes - metabolism Myeloid Cells - drug effects Myeloid Cells - immunology Myeloid Cells - metabolism Phosphorylation - drug effects Phosphorylation - immunology Receptors, CCR2 - genetics Receptors, CCR2 - immunology Receptors, CCR2 - metabolism Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - drug effects Signal Transduction - genetics Signal Transduction - immunology STAT5 Transcription Factor - immunology STAT5 Transcription Factor - metabolism Transcriptome - drug effects Transcriptome - genetics Transcriptome - immunology
ISSN:	1097-4180, 1097-4180
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