Elevated gut microbiome abundance of Christensenellaceae, Porphyromonadaceae and Rikenellaceae is associated with reduced visceral adipose tissue and healthier metabolic profile in Italian elderly

Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass, with effects upon morbidity and quality of life. The gut microbiome has recently emerged as a key environmental modifier of human health that...

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Vydané v:	Gut microbes Ročník 13; číslo 1; s. 1
Hlavní autori:	Tavella, Teresa, Rampelli, Simone, Guidarelli, Giulia, Bazzocchi, Alberto, Gasperini, Chiara, Pujos-Guillot, Estelle, Comte, Blandine, Barone, Monica, Biagi, Elena, Candela, Marco, Nicoletti, Claudio, Kadi, Fawzi, Battista, Giuseppe, Salvioli, Stefano, O'Toole, Paul W., Franceschi, Claudio, Brigidi, Patrizia, Turroni, Silvia, Santoro, Aurelia
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Taylor & Francis 01.01.2021 Taylor & Francis Group
Predmet:	Aged aging Aging - metabolism Aging - physiology Bacteroidetes - isolation & purification Bacteroidetes - metabolism Body Composition - physiology Clostridiales - isolation & purification Clostridiales - metabolism Diet Female Gastrointestinal Microbiome - physiology Humans inflammaging Intra-Abdominal Fat - physiology Italy Life Sciences Male Metabolome - physiology Microbiota Research Paper serum metabolome Subcutaneous Fat, Abdominal - physiology visceral adipose tissue Italy Microbiota inflammaging aging diet serum metabolome visceral adipose tissue
ISSN:	1949-0976, 1949-0984, 1949-0984
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Shrnutí:	Aging is accompanied by physiological changes affecting body composition and functionality, including accumulation of fat mass at the expense of muscle mass, with effects upon morbidity and quality of life. The gut microbiome has recently emerged as a key environmental modifier of human health that can modulate healthy aging and possibly longevity. However, its associations with adiposity in old age are still poorly understood. Here we profiled the gut microbiota in a well-characterized cohort of 201 Italian elderly subjects from the NU-AGE study, by 16S rRNA amplicon sequencing. We then tested for association with body composition from dual-energy X-ray absorptiometry (DXA), with a focus on visceral and subcutaneous adipose tissue. Dietary patterns, serum metabolome and other health-related parameters were also assessed. This study identified distinct compositional structures of the elderly gut microbiota associated with DXA parameters, diet, metabolic profiles and cardio-metabolic risk factors.
Bibliografia:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 PMCID: PMC7889099 These authors contributed equally to the work.
ISSN:	1949-0976 1949-0984 1949-0984
DOI:	10.1080/19490976.2021.1880221