Bidirectional modulation of incubation of cocaine craving by silent synapse-based remodeling of prefrontal cortex to accumbens projections

Glutamatergic projections from the medial prefrontal cortex (mPFC) to nucleus accumbens (NAc) contribute to cocaine relapse. Here we show that silent synapse-based remodeling of the two major mPFC-to-NAc projections differentially regulated the progressive increase in cue-induced cocaine seeking aft...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Jg. 83; H. 6; S. 1453
Hauptverfasser:	Ma, Yao-Ying, Lee, Brian R, Wang, Xiusong, Guo, Changyong, Liu, Lei, Cui, Ranji, Lan, Yan, Balcita-Pedicino, Judith J, Wolf, Marina E, Sesack, Susan R, Shaham, Yavin, Schlüter, Oliver M, Huang, Yanhua H, Dong, Yan
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 17.09.2014
Schlagworte:	Animals Cocaine-Related Disorders - physiopathology Craving - physiology Drug-Seeking Behavior - physiology Electrophysiology Male Neural Pathways - drug effects Neural Pathways - physiopathology Neuronal Plasticity - physiology Nucleus Accumbens - drug effects Nucleus Accumbens - physiopathology Optogenetics Prefrontal Cortex - drug effects Prefrontal Cortex - physiopathology Rats Rats, Sprague-Dawley Synapses - drug effects Synapses - physiology
ISSN:	1097-4199, 1097-4199
Online-Zugang:	Weitere Angaben
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