Effect of polygenic risk scores on depression in childhood trauma

Research on gene × environment interaction in major depressive disorder (MDD) has thus far primarily focused on candidate genes, although genetic effects are known to be polygenic. To test whether the effect of polygenic risk scores on MDD is moderated by childhood trauma. The study sample consisted...

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Vydáno v:	British journal of psychiatry Ročník 205; číslo 2; s. 113 - 119
Hlavní autoři:	Peyrot, Wouter J., Milaneschi, Yuri, Abdellaoui, Abdel, Sullivan, Patrick F., Hottenga, Jouke J., Boomsma, Dorret I., Penninx, Brenda W. J. H.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Cambridge, UK Cambridge University Press 01.08.2014 Maney Royal College of Psychiatrists
Témata:	Adult Adult and adolescent clinical studies Adult Survivors of Child Abuse - statistics & numerical data Adverse childhood experiences Anxiety Biological and medical sciences Bipolar disorder Candidates Case-Control Studies Child Child abuse & neglect Child Abuse - statistics & numerical data Childhood Children Depression Depressive Disorder, Major - epidemiology Depressive Disorder, Major - genetics Depressive personality disorders Emotional abuse Female Gene-Environment Interaction Genes Genetic Predisposition to Disease Genetics Genomes Genomics Health surveys Humans Longitudinal Studies Male Medical diagnosis Medical sciences Mental depression Mental disorders Mental health Meta-analysis Middle Aged Miscellaneous Mood disorders Netherlands - epidemiology Power Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Risk Risk Assessment Risk Factors Schizophrenia Serotonin Sex crimes Systematic review Trauma Netherlands Mood disorder Genetics Depression Polygenic Genetic determinism Early traumatism
ISSN:	0007-1250, 1472-1465, 1472-1465
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Shrnutí:	Research on gene × environment interaction in major depressive disorder (MDD) has thus far primarily focused on candidate genes, although genetic effects are known to be polygenic. To test whether the effect of polygenic risk scores on MDD is moderated by childhood trauma. The study sample consisted of 1645 participants with a DSM-IV diagnosis of MDD and 340 screened controls from The Netherlands. Chronic or remitted episodes (severe MDD) were present in 956 participants. The occurrence of childhood trauma was assessed with the Childhood Trauma Interview and the polygenic risk scores were based on genome-wide meta-analysis results from the Psychiatric Genomics Consortium. The polygenic risk scores and childhood trauma independently affected MDD risk, and evidence was found for interaction as departure from both multiplicativity and additivity, indicating that the effect of polygenic risk scores on depression is increased in the presence of childhood trauma. The interaction effects were similar in predicting all MDD risk and severe MDD risk, and explained a proportion of variation in MDD risk comparable to the polygenic risk scores themselves. The interaction effect found between polygenic risk scores and childhood trauma implies that (1) studies on direct genetic effect on MDD gain power by focusing on individuals exposed to childhood trauma, and that (2) individuals with both high polygenic risk scores and exposure to childhood trauma are particularly at risk for developing MDD.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Undefined-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	0007-1250 1472-1465 1472-1465
DOI:	10.1192/bjp.bp.113.143081