Abundant associations with gene expression complicate GWAS follow-up

With increasing cohort size and phenotyping, GWAS have identified more than 70,000 associated variants1. Because as many as 90% of GWAS variants fall within non-coding regions, most of them have unknown functional importance2. [...]LocusCompare integrates eQTLs from 48 tissues in the GTEx study (ver...

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Bibliographic Details
Published in:	Nature genetics Vol. 51; no. 5; pp. 768 - 769
Main Authors:	Liu, Boxiang, Gloudemans, Michael J., Rao, Abhiram S., Ingelsson, Erik, Montgomery, Stephen B.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.05.2019 Nature Publishing Group
Subjects:	38 38/91 45 45/43 631/114 631/208/191 631/208/205 692/308/2056 Agriculture Animal Genetics and Genomics Bioengineering Bioinformatics Biomedical and Life Sciences Biomedicine Brain Cancer Research Cardiovascular agents Cardiovascular disease Coronary artery Coronary vessels Correspondence Databases, Genetic Datasets Diabetes mellitus Diabetes research False Positive Reactions Follow-Up Studies Gene Expression Gene Function Genetic research Genetics Genome-wide association studies Genome-Wide Association Study - statistics & numerical data Genomics Human Genetics Humans Hypotheses Management Medical schools Medicine Methods Methylation Muscles Phenotyping Polymorphism, Single Nucleotide Quantitative Trait Loci Retina Smooth muscle Software Splicing Studies Visualization
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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