Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study

Background and aims: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-...

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Veröffentlicht in:	Biomedicines Jg. 11; H. 3; S. 838
Hauptverfasser:	Farrugia, Marwin A., Le Corvec, Maëna, Renou, Christophe, Nousbaum, Jean-Baptiste, Ouizeman, Dann J., Sire, Olivier, Loréal, Olivier, Tariel, Hugues, Bernard, Jérôme, Piche, Thierry, Tran, Albert, Ait-Oufella, Hafid, Landraud, Luce, Gual, Philippe, Anty, Rodolphe
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Switzerland MDPI AG 09.03.2023 MDPI
Schlagworte:	Ascites ascites fluid Calibration Cirrhosis Cytokines Diagnosis Discriminant analysis Hepatitis infection Infrared spectroscopy Laboratories Life Sciences Liver cirrhosis Liver diseases Methods mid-infrared spectroscopy Patients Peritonitis Principal components analysis Sensors Software Spectrum analysis spontaneous bacterial peritonitis France Paris France ascites fluid mid-infrared spectroscopy infection spontaneous bacterial peritonitis cirrhosis
ISSN:	2227-9059, 2227-9059
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Abstract	Background and aims: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP. Patients and Methods: Cirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86). Results: Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%. Conclusion: The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation.
AbstractList	Background and aims: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP. Patients and Methods: Cirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86). Results: Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%. Conclusion: The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation. A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP. Cirrhotic patients ( = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group ( = 170) and a validation group ( = 86). Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%. The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation. A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP.BACKGROUND AND AIMSA highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP.Cirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86).PATIENTS AND METHODSCirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86).Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%.RESULTSMost of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%.The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation.CONCLUSIONThe results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation.
Audience	Academic
Author	Bernard, Jérôme Renou, Christophe Anty, Rodolphe Sire, Olivier Le Corvec, Maëna Loréal, Olivier Farrugia, Marwin A. Nousbaum, Jean-Baptiste Piche, Thierry Tran, Albert Ait-Oufella, Hafid Ouizeman, Dann J. Tariel, Hugues Landraud, Luce Gual, Philippe
AuthorAffiliation	3 Centre Hospitalier de Hyères, Bd Maréchal Juin, 83400 Hyères, France 7 INSERM, U1065, C3M, Université Côte d’Azur, 06000 Nice, France 2 DIAFIR, Avenue Chardonnet, Parc Lorans 26J, 35000 Rennes, France 6 NUMECAN, UMR INSERM 1241, Centre Hospitalier Universitaire, 35000 Rennes, France 1 Service d’Hépatologie, Centre Hospitalier Universitaire, Hôpital Archet 2, 151 Route de Saint-Antoine, 06000 Nice, France 8 Service de Réanimation Médicale, AP-HP, Hôpital Saint-Antoine, INSERM UMR 991, Inserm U970, Paris Research Cardiovascular Center, Université Pierre et Marie Curie, 75012 Paris, France 9 Université Paris Cité and Université Sorbonne Paris Nord, INSERM, IAME, Louis Mourier Hospital, 92700 Paris, France 5 IRDL, UMR CNRS 6027, Université Bretagne Sud, 56000 Vannes, France 4 Centre Hospitalier Régional Universitaire de Brest, 2, Avenue Foch, 29609 Brest, France
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Cites_doi	10.1136/gutjnl-2015-310160 10.1111/j.1365-2036.2008.03735.x 10.1016/j.jhepr.2019.09.005 10.1371/journal.pone.0185997 10.1016/j.jbspin.2015.05.009 10.1002/hep.21588 10.1038/ajg.2016.344 10.1111/hepr.13239 10.12669/pjms.326.10995 10.1016/j.advms.2013.07.006 10.7243/2055-088X-1-1 10.1053/j.gastro.2008.05.045 10.1186/1471-2105-12-77 10.1002/hep.31884 10.5009/gnl15120 10.1016/j.cmi.2017.08.001 10.4291/wjgp.v3.i5.92 10.1093/rheumatology/keaa373 10.4254/wjh.v10.i2.254
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Keywords	ascites fluid mid-infrared spectroscopy infection spontaneous bacterial peritonitis cirrhosis
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References	Ichou (ref_11) 2016; 65 Hartleb (ref_6) 2014; 59 Cadranel (ref_4) 2008; 28 ref_14 Albert (ref_10) 2016; 83 ref_12 Mousa (ref_19) 2016; 10 Nousbaum (ref_16) 2007; 45 ref_22 Albert (ref_9) 2021; 60 Shizuma (ref_1) 2018; 10 Biggins (ref_13) 2021; 74 Briot (ref_17) 2016; 111 Lagadinou (ref_18) 2014; 1 Parsi (ref_21) 2008; 135 Weil (ref_20) 2019; 49 Anty (ref_8) 2019; 1 Suliman (ref_5) 2012; 3 ref_15 Wu (ref_7) 2016; 32 Bartoletti (ref_2) 2018; 24 Popoiag (ref_3) 2021; 59 Oey (ref_23) 2016; 74
References_xml	– volume: 65 start-page: 536 year: 2016 ident: ref_11 article-title: Ascitic fluid TREM-1 for the diagnosis of spontaneous bacterial peritonitis publication-title: Gut doi: 10.1136/gutjnl-2015-310160 – volume: 28 start-page: 282 year: 2008 ident: ref_4 article-title: Review article: The utility of reagent strips in the diagnosis of infected ascites in cirrhotic patients publication-title: Aliment. Pharmacol. Ther. doi: 10.1111/j.1365-2036.2008.03735.x – volume: 1 start-page: 361 year: 2019 ident: ref_8 article-title: The mid-infrared spectroscopy: A novel non-invasive diagnostic tool for NASH diagnosis in severe obesity publication-title: JHEP Rep. doi: 10.1016/j.jhepr.2019.09.005 – ident: ref_22 doi: 10.1371/journal.pone.0185997 – volume: 83 start-page: 318 year: 2016 ident: ref_10 article-title: A novel method for a fast diagnosis of septic arthritis using mid infrared and deported spectroscopy publication-title: Jt. Bone Spine doi: 10.1016/j.jbspin.2015.05.009 – volume: 45 start-page: 1275 year: 2007 ident: ref_16 article-title: Diagnostic accuracy of the Multistix 8 SG reagent strip in diagnosis of spontaneous bacterial peritonitis publication-title: Hepatology doi: 10.1002/hep.21588 – volume: 111 start-page: 1402 year: 2016 ident: ref_17 article-title: The Periscreen Strip Is Highly Efficient for the Exclusion of Spontaneous Bacterial Peritonitis in Cirrhotic Outpatients publication-title: Am. J. Gastroenterol. doi: 10.1038/ajg.2016.344 – volume: 49 start-page: 72 year: 2019 ident: ref_20 article-title: Accuracy of calprotectin using the Quantum Blue Reader for the diagnosis of spontaneous bacterial peritonitis in liver cirrhosis publication-title: Hepatol. Res. doi: 10.1111/hepr.13239 – volume: 32 start-page: 1484 year: 2016 ident: ref_7 article-title: The role of serum procalcitonin and C-reactive protein levels in predicting spontaneous bacterial peritonitis in patients with advanced liver cirrhosis publication-title: Pak. J. Med. Sci. doi: 10.12669/pjms.326.10995 – ident: ref_12 – volume: 59 start-page: 52 year: 2014 ident: ref_6 article-title: Procalcitonin and macrophage inflammatory protein-1 beta (MIP-1β) in serum and peritoneal fluid of patients with decompensated cirrhosis and spontaneous bacterial peritonitis publication-title: Adv. Med. Sci. doi: 10.1016/j.advms.2013.07.006 – volume: 1 start-page: 1 year: 2014 ident: ref_18 article-title: Alterations in cytokine measurements in ascitic fluid of cirrhotic patients with and without spontaneous bacterial peritonitis publication-title: Clin. Hepatol. Hepat. Rep. doi: 10.7243/2055-088X-1-1 – volume: 135 start-page: 803 year: 2008 ident: ref_21 article-title: Ascitic fluid lactoferrin for diagnosis of spontaneous bacterial peritonitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.05.045 – ident: ref_14 doi: 10.1186/1471-2105-12-77 – volume: 74 start-page: 1014 year: 2021 ident: ref_13 article-title: Diagnosis, Evaluation, and Management of Ascites, Spontaneous Bacterial Peritonitis and Hepatorenal Syndrome: 2021 Practice Guidance by the American Association for the Study of Liver Diseases publication-title: Hepatology doi: 10.1002/hep.31884 – volume: 59 start-page: 345 year: 2021 ident: ref_3 article-title: Spontaneous bacterial peritonitis: Update on diagnosis and treatment publication-title: Rom. J. Intern. Med. – ident: ref_15 – volume: 10 start-page: 624 year: 2016 ident: ref_19 article-title: Ascitic Fluid Calprotectin and Serum Procalcitonin as Accurate Diagnostic Markers for Spontaneous Bacterial Peritonitis publication-title: Gut Liver doi: 10.5009/gnl15120 – volume: 24 start-page: 546.e1 year: 2018 ident: ref_2 article-title: A prospective multicentre study of the epidemiology and outcomes of bloodstream infection in cirrhotic patients publication-title: Clin. Microbiol. Infect. doi: 10.1016/j.cmi.2017.08.001 – volume: 3 start-page: 92 year: 2012 ident: ref_5 article-title: Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis publication-title: World J. Gastrointest. Pathophysiol. doi: 10.4291/wjgp.v3.i5.92 – volume: 60 start-page: 1158 year: 2021 ident: ref_9 article-title: Ruling out septic arthritis risk in a few minutes using mid-infrared spectroscopy in synovial fluids publication-title: Rheumatology doi: 10.1093/rheumatology/keaa373 – volume: 10 start-page: 254 year: 2018 ident: ref_1 article-title: Spontaneous bacterial and fungal peritonitis in patients with liver cirrhosis: A literature review publication-title: World J. Hepatol. doi: 10.4254/wjh.v10.i2.254 – volume: 74 start-page: 257 year: 2016 ident: ref_23 article-title: Reagent strips are efficient to rule out spontaneous bacterial peritonitis in cirrhotics publication-title: Neth J. Med.
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Snippet	Background and aims: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The... A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present... BACKGROUND AND AIMS: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The...
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SubjectTerms	Ascites ascites fluid Calibration Cirrhosis Cytokines Diagnosis Discriminant analysis Hepatitis infection Infrared spectroscopy Laboratories Life Sciences Liver cirrhosis Liver diseases Methods mid-infrared spectroscopy Patients Peritonitis Principal components analysis Sensors Software Spectrum analysis spontaneous bacterial peritonitis
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Title	Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study
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