NK cell heparanase controls tumor invasion and immune surveillance

NK cells are highly efficient at preventing cancer metastasis but are infrequently found in the core of primary tumors. Here, have we demonstrated that freshly isolated mouse and human NK cells express low levels of the endo-β-D-glucuronidase heparanase that increase upon NK cell activation. Heparan...

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Bibliographic Details
Published in:	The Journal of clinical investigation Vol. 127; no. 7; pp. 2777 - 2788
Main Authors:	Putz, Eva M., Mayfosh, Alyce J., Kos, Kevin, Barkauskas, Deborah S., Nakamura, Kyohei, Town, Liam, Goodall, Katharine J., Yee, Dean Y., Poon, Ivan K.H., Baschuk, Nikola, Souza-Fonseca-Guimaraes, Fernando, Hulett, Mark D., Smyth, Mark J.
Format:	Journal Article
Language:	English
Published:	United States American Society for Clinical Investigation 01.07.2017
Subjects:	Angiogenesis Animals Antitumor activity Biomedical research Breast cancer Cancer Cancer metastasis Carcinogens Carcinoma Cell activation Cell Line, Tumor Cytokines Cytokines - genetics Cytokines - immunology Development and progression Female Heparin Lyase - genetics Heparin Lyase - immunology Humans Immune checkpoint Immunologic Surveillance Immunosurveillance Immunotherapy Inflammation Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - pathology Localization Lymphocytes Lymphoma Male Mammals Mammary gland Melanoma Metastases Metastasis Mice Mice, Knockout Natural killer cells Neoplasm Invasiveness - genetics Neoplasm Invasiveness - immunology Neoplasm Metastasis Neoplasms, Experimental - genetics Neoplasms, Experimental - immunology Neoplasms, Experimental - pathology NK Cell Lectin-Like Receptor Subfamily K - genetics NK Cell Lectin-Like Receptor Subfamily K - immunology NKG2 antigen Nuclear Matrix-Associated Proteins - genetics Nuclear Matrix-Associated Proteins - immunology Nucleocytoplasmic Transport Proteins - genetics Nucleocytoplasmic Transport Proteins - immunology Physiological aspects Prostate cancer Prostate carcinoma Proteins Rodents Studies T cell receptors Tumor cell lines Tumors
ISSN:	0021-9738, 1558-8238, 1558-8238
Online Access:	Get full text
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