No Hepatitis Delta Virus Seropositivity among Blood Donors with Overt and Occult Hepatitis B Infection in Dalian, Liaoning Province, China

Hepatitis delta virus (HDV) is an obligate satellite of hepatitis B virus (HBV). Dual HDV/HBV infection is associated with down-regulated HBV replication and fast progression to severe liver disease. Although HDV is transmissible through exposure to infected blood, data about HDV infection in blood...

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Vydáno v:Viruses Ročník 15; číslo 7; s. 1509
Hlavní autoři: Deng, Xuelian, Liu, Dan, Delcourt, Maelenn Pailine, Gao, Huihui, Zhou, Lu, Candotti, Daniel
Médium: Journal Article Publikace
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.07.2023
MDPI
Témata:
Antibodies
Antigens
blood
Blood & organ donations
Blood donors
China
Delta-associated agent
Deoxyribonucleic acid
DNA
Enzymes
Epidemiology
Genomes
Health aspects
Hepatitis B
Hepatitis B surface antigen
Hepatitis B virus
Hepatitis delta virus
Immunoglobulin G
Immunoglobulin M
Infections
Life Sciences
Liver cancer
Liver cirrhosis
Liver diseases
mixed infection
occult hepatitis B infection
Physiological aspects
Plasma
satellites
Serology
seroprevalence
Viruses
China
Liaoning China
Beijing China
seroprevalence
blood donors
hepatitis B virus
occult hepatitis B infection
hepatitis delta virus
ISSN:1999-4915, 1999-4915
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Shrnutí:Hepatitis delta virus (HDV) is an obligate satellite of hepatitis B virus (HBV). Dual HDV/HBV infection is associated with down-regulated HBV replication and fast progression to severe liver disease. Although HDV is transmissible through exposure to infected blood, data about HDV infection in blood donors remain scarce. Between 2011 and 2021, 869,633 donations were collected from prequalified donors in Dalian, China. In total, 1060 (0.12%) were confirmed HBsAg and/or HBV DNA-reactive. Subsequently, anti-HDV IgG was tested in 2175 donations, including 65 that tested HBsAg+ pre donation, 1017 confirmed HBV-positive (507 HBsAg+/HBV DNA+, 33 HBsAg+/DNA−, 477 HBsAg-/DNA+ (451 occult (OBI) and 26 acute infections)), 327 viral DNA non-repeated-reactive, 397 anti-HBc-only, and 369 anti-HBs-only. Two (0.09%) samples tested anti-HDV IgG weakly reactive but were unconfirmed by IgM and IgG repeat testing with alternative assays, suggesting an initial false reactivity. In addition, HDV testing in a subgroup of confirmed OBI donors, comprising 451 donors from Dalian and 126 archived samples of OBI donors from around the world, showed only one non-Chinese donor to be repeatedly anti-HDV-reactive, suggesting that HDV/HBV coinfection does not play a significant role in the genesis of OBI. The overall data suggested an extremely low prevalence of HDV infection among blood donors in Liaoning province, Northeast China.
Bibliografie:ObjectType-Article-1
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ISSN:1999-4915
1999-4915
DOI:10.3390/v15071509