Hyperphosphorylated tau in young and middle-aged subjects

The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages ranging from 22 to 50 years upon death, were immunohistochemically assessed for neurodegenerative changes, i.e., hyperphosphorylated tau (HPτ) and β-amyloid (Aβ) pathology in predilection neuroanatomical areas. HPτ...

Celý popis

Uloženo v:

Podrobná bibliografie
Vydáno v:	Acta neuropathologica Ročník 123; číslo 1; s. 97 - 104
Hlavní autoři:	Elobeid, Adila, Soininen, Hilkka, Alafuzoff, Irina
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Berlin/Heidelberg Springer-Verlag 01.01.2012 Springer Springer Nature B.V
Témata:	Adult Age Age Factors Aging Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amyloid beta-Peptides - metabolism Anatomy beta -Amyloid Brain Brain - metabolism Brain - pathology Brain architecture Cognitive ability Cognitively unimpaired Cortex Emotional disorders Female Geriatrics Humans Hyperphosphorylated tau Immunohistochemistry Locus coeruleus Male Medical research Medicine Medicine & Public Health Medicine, Experimental Microtubule-associated proteins Middle age Middle Aged Mood Mood disorders Neurodegeneration Neuropathology Neurosciences Original Paper Pathology Phosphorylation - physiology Post-mortem study Risk factors Tau protein tau Proteins - metabolism Finland Immunohistochemistry Hyperphosphorylated tau Middle-aged Post-mortem study Locus coeruleus Cognitively unimpaired
ISSN:	0001-6322, 1432-0533, 1432-0533
On-line přístup:	Získat plný text
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!

Popis
Shrnutí:	The brain tissue obtained from ninety-five cognitively unimpaired subjects, with ages ranging from 22 to 50 years upon death, were immunohistochemically assessed for neurodegenerative changes, i.e., hyperphosphorylated tau (HPτ) and β-amyloid (Aβ) pathology in predilection neuroanatomical areas. HPτ pathology was observed in the transentorhinal cortex and/or the locus coeruleus (LC) in 33% of the subjects, without any obvious risk factors known to alter the microtubule-associated protein. HPτ pathology was noted in the LC in 25 out of 83 subjects (30%), lacking concomitant cortical Aβ or transentorhinal HPτ pathology. This observation was present even when assessing only one routine section of 7 μm thickness. The recent suggestion of prion-like propagation of neurodegeneration and the finding of neurodegeneration being quite common in middle-aged persons is alarming. It is noteworthy, however, that a substantial number of neurologically unimpaired subjects even at a very old age display only sparse to modest extent of neurodegenerative pathology. Thus, only a subset of subjects with neurodegenerative changes early in life seem to progress to a symptomatic disease with ageing. This observation brings forth the notion that other, yet unknown modifying factors influence the progression of degeneration that leads to a symptomatic disorder. The known association between alterations in the LC and mood disorders, and the finding of the LC being frequently affected with HPτ pathology suggest that clinicopathological studies on young subjects both with or without mood disorders are warranted.
Bibliografie:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-1 ObjectType-Feature-2 content type line 23
ISSN:	0001-6322 1432-0533 1432-0533
DOI:	10.1007/s00401-011-0906-z