A Toxicological Evaluation of Mango Leaf Extract (Mangifera indica) Containing 60% Mangiferin

A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromo...

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Vydané v:Journal of toxicology Ročník 2019; číslo 2019; s. 1 - 14
Hlavní autori: Szakonyiné, Ilona Pasics, Vértesi, Adél, Hirka, Gábor, Clewell, Amy, Endres, John R., Glávits, Róbert, Reddeman, Robin A., Béres, Erzsébet
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: Cairo, Egypt Hindawi Publishing Corporation 2019
Hindawi
John Wiley & Sons, Inc
Wiley
Predmet:
Biocompatibility
Chromosome aberrations
Councils
Experiments
Genotoxicity
In vitro methods and tests
In vivo methods and tests
Laboratories
Leaves
Mangifera indica
Mangoes
Mutation
Pharmaceuticals
Plant extracts
Sodium
Studies
Test methods
Toxicity
Toxicity testing
Toxicology
Hungary
France
Spain
Asia
United States > US
Germany
ISSN:1687-8191, 1687-8205
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Shrnutí:A battery of OECD- and GLP-compliant toxicological studies was performed on mango leaf extract (Mangifera indica) containing 60% mangiferin (MLE). No evidence of genotoxicity was found in a bacterial reverse mutation test (Ames). While evidence of clastogenic activity was noted in an in vitro chromosomal aberration test, an in vivo mammalian micronucleus test showed no findings up to the limit dose (2000 mg/kg bw). A 90-day repeated dose oral toxicity study was conducted in rats using doses of 0 (vehicle control), 500, 1000, and 2000 mg/kg bw/day. Based on the lack of mortality or toxic effects in the 90-day study, the NOAEL for MLE in Han:Wist male and female rats was determined to be 2000 mg/kg bw/day, the highest dose tested.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Academic Editor: Brad Upham
ISSN:1687-8191
1687-8205
DOI:10.1155/2019/4763015